Insecticide distribution model in human tissues viewing worker's health monitoring programs

Paraíba, L. C.; Castro, V. L. S. S. de; Maia, A. de H. N.

doi:10.1590/s1516-89132009000400011

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…Given that fish are lower on the food cycle, bioaccumulation of pesticides may rise in the tissues of their predators and consumers such as humans, having an adverse effect on the health and survival of these individuals (Lushchak et al 2018;Rani et al 2022). Therefore, the bioaccumulation of these pollutants in fish and the possible biomagnifications in humans are considered to be a hazard to hepatotoxic and neurologic injuries as well as reproductive disorders (Paraíba et al 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Predicting potential harmful effects of the compounds is easier with the knowledge of their distribution in organisms and liposolubility. It is generally known that some compounds build up in compartments within the environment and within living things (Paraíba et al 2009 ). Fish, therefore, absorb insecticides after coming into contact with them in water.…”

Section: Discussionmentioning

confidence: 99%

“…The organism’s ability to absorb and disperse toxicants depends on both the toxicant and the organism. Examples of these factors include the compound’s hydrosolubility, liposolubility, and degree of ionization, octanol–water partition coefficient, and tissue lipid contents among others (Paraíba et al 2009 ). ABM has been discovered to collect at elevated levels in fatty tissue, such as the brain, liver, and fat, because of its strong lipophilic nature (González Canga et al 2009 ).…”

Section: Discussionmentioning

confidence: 99%

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The potential effect of Moringa oleifera ethanolic leaf extract against oxidative stress, immune response disruption induced by abamectin exposure in Oreochromis niloticus

Reda

Helmy

Osman

et al. 2023

Environ Sci Pollut Res

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Abamectin (ABM), a naturally fermented product of Streptomyces avermitilis, is applied to pest control in livestock and agriculture fields. The aim of the current study is to evaluate the protective effects of Moringa oleifera leaf ethanolic extract (MOE) on biochemical changes including oxidative stress indices, immune response marker, lipid profiles as well as mRNA expression of immune related genes, and abamectin (ABM, 5% EC) residue levels in Nile tilapia (Oreochromis niloticus) exposed to a sub-lethal concentration (0.5 µg/l) for 28 days. Disturbance in liver and kidney biomarkers was markedly increased in ABM-exposed fish compared to the control group. Malondialdehyde levels in the liver and brain tissues, as well as the activities of glutathione-s-transferase, superoxide dismutase, and glutathione peroxides, all increased significantly in ABM group. Additionally, ABM exposure increased the levels of interleukin 10 beta and growth factor gene expression. On the other hand, fish exposed to ABM had significantly lower serum alkaline phosphatase, creatinine, high-density lipoprotein, glutathione peroxides in brain, glutathione in liver and brain tissues, lysozyme activity, nitric oxide, immunoglobulin M, tumor necrosis factor, and interleukin 1 beta as compared to the control group. The recorded detrimental effects of ABM on tilapia have been overcome by the addition of MOE to the diet (1%) and ameliorating hepato-renal damage and enhancing antioxidant activity, innate immune responses, and upregulating the anti-inflammatory gene expression. Therefore, it could be concluded that MOE dietary supplementation at 1% could be used to counteract the oxidative stress, immune response disruption induced by abamectin exposure in Oreochromis niloticus, and reduce its accumulation in fish tissues.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The potential effect of Moringa oleifera ethanolic leaf extract against oxidative stress, immune response disruption induced by abamectin exposure in Oreochromis niloticus

Reda

Helmy

Osman

et al. 2023

Environ Sci Pollut Res

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“…Some OP pesticides such as chlorpyrifos, dimethoate, ethion, parathion methyl, and triazophos have low water solubility (with Log K ow ≥ 1). These pesticides have the potential to deposit in adipose tissues including breast milk [24,25]. Infants can be postnatally exposed to OP pesticides via breastfeeding.…”

Section: Introductionmentioning

confidence: 99%

A single method for detecting 11 organophosphate pesticides in human plasma and breastmilk using GC-FPD

Naksen

Prapamontol

Mangklabruks

et al. 2016

Journal of Chromatography B

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Organophosphate (OP) pesticides are widely used for crop protection in many countries including Thailand. Aside from causing environmental contamination, they affect human health especially by over-stimulating of the neurotransmission system. OP pesticides, as with other non-persistent pesticides, degrade quickly in the environment as well as are metabolized quite rapidly in humans. Assessing human exposures to these compounds requires analytical methods that are sensitive, robust, and most importantly, suitable for specific laboratory settings. The aim of this study was to develop and validate an analytical method for measuring 11 OP pesticide residues in human plasma and breast milk. Analytes in both plasma and breast milk samples were extracted with acetone and methylene chloride, cleaned-up using aminopropyl solid phase extraction cartridges, and analyzed by gas chromatography with flame photometric detection. The optimized method exhibited good linearity, with the coefficients of determination of 0.996–0.999 and <7% error about the slope. Extraction recoveries from spiked plasma and breast milk samples at low and medium concentrations (0.8–5.0 and 1.6–10 ng mL−1, respectively) ranged from 59.4 % (ethion) to 94.0 % (chlorpyrifos). Intra-batch and inter-batch precisions ranged from 2.3–18.9% and 5.8–19.5%, respectively. Method detection limits of plasma and breast milk ranged from 0.18–1.36 and 0.09–2.66 ng mL−1, respectively. We analyzed 63 plasma and 30 breastmilk samples collected from farmworkers in Chiang Mai Province to determine the suitability of this method for occupational exposure assessment. Of the 11 pesticides measured, seven were detected in plasma samples and five were detected in breast milk samples. Mass spectrometry was used to confirm results. Overall, this method is rapid and reliable. It offers the laboratories with limited access to mass spectrometry a capacity to investigate levels OP pesticides in plasma and breastmilk in those occupationally exposed for health risk assessment.

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“…1 Residues of pesticides have been detected even in human tissues. [2][3][4] In the environment pesticides can undergo a series of biotic and/or abiotic transformations and current studies have evidenced that transformation products can be prevalent. 5,6 The environmental metabolites may have different stabilities, polarities and/or toxicities, therefore obtaining data on pesticides and their degradates is critical for understanding the environmental fate and predicting the potential impact of these compounds on the environment.…”

Section: Introductionmentioning

confidence: 99%

Chlorpropham and phenisopham: phototransformation and ecotoxicity of carbamates in the aquatic environment

Passananti¹,

Lavorgna²,

Iesce

et al. 2014

Environ. Sci.: Processes Impacts

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In this study, a comparison of two carbamic pesticides, chlorpropham and phenisopham, was carried out in terms of both photodegradability and ecotoxicity. The photochemical behaviour of the two pesticides was investigated under environmental-like conditions (aqueous media, UVB or solar irradiation). The photochemical kinetic parameters were calculated by irradiating 5 × 10(-5) M solutions (H₂O-CH₃CN, 9 : 1 v/v) using UVB lamps. For chlorpropham and phenisopham similar half-life times (39.0 and 55.0 min) were determined. Irradiation by sunlight leads to longer degradation half-life times (about 3 months), while it is possible to observe the formation of the same photoproducts. The well-known dechlorination reaction to a hydroxyphenylcarbamate was observed for chlorpropham. Phenisopham undergoes photo-Fries reaction to give rearranged products (hydroxybenzamides) and fragmentation products (hydroxyphenylcarbamate and N-ethylaniline). Acute and chronic toxicity tests of pesticides and their photoproducts were performed on organisms from two levels of the freshwater aquatic chain, the anostraca crustacean Thamnocephalus platyurus, the rotifer Brachionus calyciflorus and the alga Pseudokirchneriella subcapitata. The acute results showed that chlorpropham had median lethal concentrations for the crustacean T. platyurus and the rotifer B. calyciflorus of 10.16 and 35.19 mg L(-1), respectively, and phenisopham did not show any acute toxicity as the derivatives up to 10 mg L(-1). The only exception was N-ethylaniline which exhibited an acute LC₅₀ value of 0.46 mg L(-1). Phenisopham was the most toxic in the long term exposure while its five derivatives showed lower chronic potential for rotifers and algae. The same trend was observed for chlorpropham except for rotifers.

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Insecticide distribution model in human tissues viewing worker's health monitoring programs

Cited by 10 publications

References 25 publications

The potential effect of Moringa oleifera ethanolic leaf extract against oxidative stress, immune response disruption induced by abamectin exposure in Oreochromis niloticus

The potential effect of Moringa oleifera ethanolic leaf extract against oxidative stress, immune response disruption induced by abamectin exposure in Oreochromis niloticus

A single method for detecting 11 organophosphate pesticides in human plasma and breastmilk using GC-FPD

Chlorpropham and phenisopham: phototransformation and ecotoxicity of carbamates in the aquatic environment

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