Evaluation of protein quality from genetically modified and organic soybean in two consecutives generations of wistar rats

Daleprane, Julio Beltrame; Pacheco, Juliana Tomaz; Boaventura, Gilson Teles

doi:10.1590/s1516-89132009000400007

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…The ingredients of the diets (Table 1) were homogenized in an industrial mixer with boiling water. The obtained mass was transformed into tablets, which were dried in a ventilated oven at 60°C for 24 h, properly identified, and stored under refrigeration (4 ± 2°C) until the time of use (Daleprane, Pacheco, & Boaventura, 2009). …”

Section: Experimental Chowmentioning

confidence: 99%

Dietary flaxseed supplementation improves endothelial function in the mesenteric arterial bed

Daleprane

Batista

Pacheco

et al. 2010

Food Research International

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The aim of this study was to evaluate the influence of flaxseed diet supplementation on endothelial function in the mesenteric arterial bed of rats. Twenty-four rats were divided into 3 groups: Control Group (CG; 10% protein; 5% fiber; 7% lipid); Flaxseed Group (FG, supplemented with 25% flaxseed; 10% protein; 7% fiber; 11% lipid); and Modified Control Group (MCG; 10% protein; 7% fiber; 11% lipid). The blood was obtained by cardiac puncture (after 180 days) and the serum was separated for lipid profile analyses. The vasodilator effect of acetylcholine (1-100 pmol) was evaluated in the preconstricted isolated rat vascular bed. FG showed a 47% increase in HDL-C, a 22% reduction in LDL-C, a 23% reduction in triacylglycerols, and an increased (p b 0.05) vasodilator response to acetylcholine, in relation to the CG and CMG groups. These results suggest that flaxseed has a cardioprotective effect by improving the blood lipid profile and endothelial function.

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Section: Experimental Chowmentioning

confidence: 99%

Dietary flaxseed supplementation improves endothelial function in the mesenteric arterial bed

Daleprane

Batista

Pacheco

et al. 2010

Food Research International

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“…Long-term studies included rats [ 20 , 30 - 32 ], mice [ 33 - 37 ], salmon [ 38 , 39 ], beef cattle [ 40 ], dairy cows [ 41 ], macaques [ 42 ], pigs [ 19 ], and quail [ 43 ]. Multigenerational studies included rats [ 44 - 48 ], mice [ 49 - 53 ], pigs [ 54 - 56 ], bulls [ 56 ], dairy cows [ 56 ], goats [ 57 ], sheep [ 56 , 58 ], broilers [ 56 , 59 ], laying hens [ 56 , 60 ], and quail [ 21 , 61 ]. These powerful studies consistently revealed that GE had fewer unintended effects than conventional breeding techniques.…”

Section: Introductionmentioning

confidence: 99%

GMOs in animal agriculture: time to consider both costs and benefits in regulatory evaluations

Eenennaam

2013

J Animal Sci Biotechnol

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In 2012, genetically engineered (GE) crops were grown by 17.3 million farmers on over 170 million hectares. Over 70% of harvested GE biomass is fed to food producing animals, making them the major consumers of GE crops for the past 15 plus years. Prior to commercialization, GE crops go through an extensive regulatory evaluation. Over one hundred regulatory submissions have shown compositional equivalence, and comparable levels of safety, between GE crops and their conventional counterparts. One component of regulatory compliance is whole GE food/feed animal feeding studies. Both regulatory studies and independent peer-reviewed studies have shown that GE crops can be safely used in animal feed, and rDNA fragments have never been detected in products (e.g. milk, meat, eggs) derived from animals that consumed GE feed. Despite the fact that the scientific weight of evidence from these hundreds of studies have not revealed unique risks associated with GE feed, some groups are calling for more animal feeding studies, including long-term rodent studies and studies in target livestock species for the approval of GE crops. It is an opportune time to review the results of such studies as have been done to date to evaluate the value of the additional information obtained. Requiring long-term and target animal feeding studies would sharply increase regulatory compliance costs and prolong the regulatory process associated with the commercialization of GE crops. Such costs may impede the development of feed crops with enhanced nutritional characteristics and durability, particularly in the local varieties in small and poor developing countries. More generally it is time for regulatory evaluations to more explicitly consider both the reasonable and unique risks and benefits associated with the use of both GE plants and animals in agricultural systems, and weigh them against those associated with existing systems, and those of regulatory inaction. This would represent a shift away from a GE evaluation process that currently focuses only on risk assessment and identifying ever diminishing marginal hazards, to a regulatory approach that more objectively evaluates and communicates the likely impact of approving a new GE plant or animal on agricultural production systems.

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Different Protein Sources in the Maternal Diet of the Rat during Gestation and Lactation Affect Milk Composition and Male Offspring Development during Adulthood

et al. 2021

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Evaluation of protein quality from genetically modified and organic soybean in two consecutives generations of wistar rats

Abstract: ABSTRACT

Cited by 7 publications

References 15 publications

Dietary flaxseed supplementation improves endothelial function in the mesenteric arterial bed

Dietary flaxseed supplementation improves endothelial function in the mesenteric arterial bed

GMOs in animal agriculture: time to consider both costs and benefits in regulatory evaluations

Different Protein Sources in the Maternal Diet of the Rat during Gestation and Lactation Affect Milk Composition and Male Offspring Development during Adulthood

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