Effect of naringerin on biochemical parameters in the streptozotocin-induced diabetic rats

Fernandes, Ana Angélica Henrique; Novelli, Ethel L. B.; Fernandes, Adalton Mazetti; Galhardi, Cristiano Machado

doi:10.1590/s1516-89132009000100007

Cited by 24 publications

(11 citation statements)

References 43 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, AST and ALT levels were significantly increased in diabetic group animals compared to the normal control group in the current study. These results were in agreement with studies conducted by Elgazar et al (2013) and Fernandes, Novelli, Fernandes, and Galhardi (2009) in which they reported that levels of AST and ALT were increased in the serum of diabetic rats. In contrary to that, there was a decrease in plasma AST and ALT levels in both BV-treated groups.…”

Section: Discussionsupporting

confidence: 94%

Antidiabetic effect of the Egyptian honey bee (Apis mellifera) venom in alloxan-induced diabetic rats

Hassan

El-kotby

Tawfik

et al. 2019

JoBAZ

View full text Add to dashboard Cite

Background: Diabetes mellitus (DM) is one of the most common endocrinal diseases characterized by hyperglycemia and altered metabolism of lipids, carbohydrates, and proteins with an increased risk of many complications. Bioactive drugs extracted from natural sources had been used in a wide range of treatment for many diseases. This work aimed to investigate the potential antidiabetic effect of Egyptian honey bee venom (BV) in alloxan-induced diabetic rats. Subjects and methods: Forty adult male albino rats (140-180 g) were used in the study and divided into five groups each of eight rats. The normal control group, diabetic group, high-and low-dose BV-treated groups, and vildagliptintreated group. Blood samples and pancreases were collected after 6 weeks of the experiment. Results: Treatment of diabetic rats with BV revealed a significant decrease in serum glucose level accompanied by a significant increase in insulin level. Malondialdehyde (MDA), cholesterol, triglycerides, creatinine, and aminotransferases (ALT and AST) levels were significantly decreased after BV treatment in comparison with diabetic animals. Total antioxidant capacity (TAC), glutathione (GSH) contents, and catalase (CAT) activity had improved. Histological examination of the pancreas indicated a marked improvement in the islet architecture and marked regeneration of insulin-secreting β-cell in diabetic BV-treated rats. Conclusion: The study concluded that BV could have the ability to lower glucose level in diabetic rats and enhance insulin secretion, and relieved the various biochemical and histological abnormalities resulted due to diabetes metabolic disorders.

show abstract

Section: Discussionsupporting

confidence: 94%

Antidiabetic effect of the Egyptian honey bee (Apis mellifera) venom in alloxan-induced diabetic rats

Hassan

El-kotby

Tawfik

et al. 2019

JoBAZ

View full text Add to dashboard Cite

show abstract

“…Some flavonoids, the flavonols, flavones and catechins, found in the fruits, vegetables, whole grains and grasses, have been also used in medicine against osteoporosis and inflammation, because they inhibit the precaution of the prostaglandin, diminishing the synthesis of nitric oxid, having a very important antioxidant characteristic (Bianchi and Antunes, 1999;Novelli Filho and Novelli, 2005). Fernandes et al (2009) reported that the level of triacylglycerols, total cholesterol and LDL in the serum of the diabetic rat groups administred naringerin was lower than in the diabetic rat group, showing that the flavonoids decreased the triacyglycerols and total cholesterol in the rats blood. Diniz et al (2005b) found that fiber had also an antioxidant effect.…”

Section: Antioxidants and Preventionmentioning

confidence: 97%

Oxidative stress action in cellular aging

Oliveira

Schoffen

2010

Braz. arch. biol. technol.

View full text Add to dashboard Cite

show abstract

“…Three days following STZ injection, a random blood glucose (RBG) was measured using glucometer (Oncall-plus, Germany) at the tail vein. Rats with RBG level of more than 16.5 mmol/ L was considered as diabetics (19). After 4 weeks of DM induction, the rats were further subdivided into 5 groups; control (Ctr) and control-treated with naringenin (Ctr-NG), non-treated diabetic (DM-Ctr), diabetic treated with metformin (DM-MTF) as positive control group and diabetic treated with naringenin (DM-NG).…”

Section: Research Frameworkmentioning

confidence: 99%

Effects of naringenin on vascular changes in prolonged hyperglycaemia in fructose-STZ diabetic rat model

Zaidun

Sahema

Mardiana

et al. 2019

DD&T

View full text Add to dashboard Cite

Chronic uncontrolled hyperglycaemia leads to increased oxidative stress and lipid peroxidation resulting in vascular complications and accelerates the progression of diabetic atherosclerosis. Though varieties of modern drugs used in the treatment of diabetes, the complications of diabetes are increasing. Naringenin (NG), has been reported to have potent antioxidant and anti-atherosclerotic properties. However, the effects of NG as vasculoprotective agent in prolonged hyperglycaemia are not well documented. Thus, this study was aimed to determine the effect of NG against vascular changes after prolonged hyperglycaemia in a diabetic rat model. Thirty adult male Sprague-Dawley rats were induced with fructose and streptozotocin to develop the diabetic rat model. After 4 weeks, the rats were randomly divided into 5 groups each group consisting of 6 animals: control, control treated with NG, non-treated diabetes mellitus (DM), DM treated with NG and metformin-treated DM. The treatment with NG (50 mg/kg) and metformin were continued for 5 weeks. The results showed that consumption of NG at 4 weeks post diabetic did not improved blood sugar, blood pressure and serum lipid profile. However, NG did significantly improve oxidative stress parameters in the aortic tissue like malondialdehyde (MDA). Analysis through light microscopy and transmission electron microscope (TEM) reverted the histological changes caused by prolonged hyperglycaemia. The findings thus demonstrated that introduction of NG after prolonged exposure to hyperglycaemia improved the vascular deterioration in diabetic group by decreasing oxidative stress evident by the reduced in the lipid peroxidation activity. Thus, this study showed the potential use of NG as adjunct in managing the diabetic condition during late presentation.

show abstract

Effect of naringerin on biochemical parameters in the streptozotocin-induced diabetic rats

Cited by 24 publications

References 43 publications

Antidiabetic effect of the Egyptian honey bee (Apis mellifera) venom in alloxan-induced diabetic rats

Antidiabetic effect of the Egyptian honey bee (Apis mellifera) venom in alloxan-induced diabetic rats

Oxidative stress action in cellular aging

Effects of naringenin on vascular changes in prolonged hyperglycaemia in fructose-STZ diabetic rat model

Contact Info

Product

Resources

About