Effect of paclitaxel (Taxol®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in female Wistar rats

Holanda, Cecília Maria de Carvalho Xavier; Oliveira, Elias Herculano de; Rocha, Louisianny Guerra da; Barbosa, Vanessa Santos de Arruda; Spyrides, Maria Helena Constantino; Aragão, Cícero Flávio Soares; Medeiros, Aldo da Cunha

doi:10.1590/s1516-89132008000700031

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…Also,liver played an important role in the modulation of the process of carcinogenesis, as it was the primary site for the biotransformation of xenobiotics including carcinogens. Paclitaxel mediated a significant rise in the ALT and ALP levels which were reported by Itoh et al (2004) and Holanda et al (2008) in Sprague Dawley rats which were administered with paclitaxel. The injury that occurred during treatment could be attributed to a direct effect of paclitaxel in inhibiting microtubular function as it was largely metabolized by cytochrome P450 system (Scripture et al, 2005).…”

Section: Discussionmentioning

confidence: 54%

Effect of Momordica charantia L. on serum biochemical parameters in experimentally induced atypical acinar cell tumors in male wistar rats

Rajamohan¹,

Sridhar²,

Hemalatha³

et al. 2018

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The present investigation was carried out to study the effect of Momordica charantia L. (Bitter gourd) on serum biochemical parameters in male wistar rats induced with pancreatic atypical acinar cell tumor. Ninety six male wistar rats were randomized into four groups [control group, (i), azaserine group (ii), azaserine + paclitaxel (iii) and azaserine + Momordica charantia (MC) (iv) group] each comprising of 24 rats. Male wistar rats of group (ii, iii and iv) were administered with azaserine @ 30 mg per kg BW intraperitoneally (i.p.) on 21 st day of age. Paclitaxel was administered to the azaserine + paclitaxel group (iii) @ 33 mg/kg BW intraperitoneally for 6 weeks after 8 weeks post initiation of tumor and aqueous extract of Momordica charantia @ 0.34 ml/rat was administered as oral gavage for 6 weeks after 8 weeks post initiation of tumor to azaserine + Momordica charantia group (iii). The blood was collected for estimation of serum biochemical parameters at the end of 24 th week. Significant alterations in ALT, ALP, triglyceride, cholesterol, lipase and amylase levels were observed among the groups ii, iii and iv. The alterations were compared with the control and azaserine + paclitaxel group which revealed the high level of protective effect of aqueous extract of Momordica charantia, on the serum biochemical alterations.

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Section: Discussionmentioning

confidence: 54%

Effect of Momordica charantia L. on serum biochemical parameters in experimentally induced atypical acinar cell tumors in male wistar rats

Rajamohan¹,

Sridhar²,

Hemalatha³

et al. 2018

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“…43 The authors of that study reported an increase in this parameter in patients who completed polychemotherapy that included PTX. Chemotherapy in patients with diabetes requires precautions, since it has been demonstrated that some drugs can interfere with patients' blood-glucose levels, worsening the control of this disease.…”

Section: Discussionmentioning

confidence: 97%

Organic effects of associating paclitaxel with a lipid-based nanoparticle system on a nonhuman primate, <em>Cebus apella</em>

Feio¹,

Oliveira²,

Pereira³

et al. 2017

IJN

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Lipid-based nanoparticle systems have been used as vehicles for chemotherapeutic agents in experimental cancer treatments. Those systems have generally been credited with attenuating the severe toxicity of chemotherapeutic agents. This study aimed to investigate the effects of associating paclitaxel (PTX) with a lipid-based nanoparticle system on a nonhuman primate, Cebus apella , documenting the toxicity as measured by serum biochemistry, which is a detailed analysis of blood and tissue. Eighteen C. apella were studied: three animals were treated with cholesterol-rich nanoemulsion (LDE) only, without PTX, administered intravenously every 3 weeks, during six treatment cycles; six animals were treated with PTX associated with LDE at the same administration scheme, three with lower (175 mg/m 2 ) and three with higher (250 mg/m 2 ) PTX doses; and six animals were treated with commercial PTX, three with the lower and three with the higher doses. In the LDE-PTX group, no clinical toxicity appeared, and the weight–food consumption curve was similar to that of the controls. Two animals treated with commercial PTX presented weight loss, nausea and vomiting, diarrhea, skin flaking, 70% loss of body hair, and decreased physical activity. The use of LDE as a carrier at both lower and higher doses reduced the toxicity of the drug in this species, which is closely related to human subjects. This was observed not only by clinical, biochemical, and hematological profiles but also by the histopathological analysis. The results of this study support the assumption that lipid-based nanoparticle systems used as drug carriers can serve as valuable tools to decrease the toxicity and increase the safety of chemotherapeutic agents.

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“…Due to the diversity of the chemical structures founded in theses products, there are big chances to identify news molecules with anti-tumor activities (Cremasco & Starquit, 2010). The Taxol® (commercial name for Paclitaxel) discovery offers good points for this reasoning (Holanda et al, 2008). According to Rhoads (1995), while many drugs act to disrupt the cancer cells, Taxol ® paralyzes the internal structure.…”

Section: Introductionmentioning

confidence: 99%

Taxol® Separation in a Simulated Moving Bed

Cremasco¹

2011

Mass Transfer - Advanced Aspects

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Effect of paclitaxel (Taxol®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in female Wistar rats

Abstract: (ovaries, uterus, vagina, breasts, large intestine and liver

Cited by 6 publications

References 22 publications

Effect of Momordica charantia L. on serum biochemical parameters in experimentally induced atypical acinar cell tumors in male wistar rats

Effect of Momordica charantia L. on serum biochemical parameters in experimentally induced atypical acinar cell tumors in male wistar rats

Organic effects of associating paclitaxel with a lipid-based nanoparticle system on a nonhuman primate, <em>Cebus apella</em>

Taxol® Separation in a Simulated Moving Bed

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