Experimental models using radionuclides for assessment of the effects of natural drugs

Moreno, Silvana Ramos Farías; Carvalho, Jorge José de; Rebello, Bernardo Machado; Rocha, Emely Kazan; Timóteo, Margareth de Oliveira; Olej, Beni; Filho, Mário Bernardo; Caldas, Luiz Querino de Araújo

doi:10.1590/s1516-89132008000700027

Braz. arch. biol. technol.

2008

DOI: 10.1590/s1516-89132008000700027

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Experimental models using radionuclides for assessment of the effects of natural drugs

Silvana Ramos Farías Moreno

Jorge José de Carvalho

Bernardo Machado Rebello

et al.

Abstract: ABSTRACT

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Cited by 3 publications

(1 citation statement)

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“…Moreover, authors have pointed out that in nuclear medicine, it is essential the understanding and quantification of this phenomenon in order to anticipate the behavior in vivo of radiotracers (Velasques de Oliveira et al, 2010b). In addition, authors have reported that several synthetic (Nigri et al, 2002) and natural medications (Moreno et al, 2007;Moreno et al, 2008a;Moreno et al, 2008b;Moreno et al, 2008c;Souza et al, 2011) are capable of interfering with the biodistribution and/or on the radiolabeling of blood constituents. These considerations show the importance of the studies about the effect of medications on the behavior of the radiopharmaceuticals.…”

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confidence: 99%

Influence of a Ginkgo biloba extract on the binding of [F-18]-fluorodeoxyglucose (18F-FDG) on blood constituents

Aleixo¹

2013

Afr. J. Pharm. Pharmacol.

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Radiopharmaceuticals are used in procedures of nuclear medicine for the diagnosis and treatment of illnesses. Fluorine-18(18 F) is a positron emitter produced in cyclotron. It is used to get 18 fluorodeoxyglucose (18 F-FDG) that is a radiopharmaceutical utilized in the positron emission tomography scan. The aim of this work was to evaluate the in vitro effect of an extract of Ginkgo biloba extract (EGb) on the distribution in blood cells (BC) and plasma (P) compartments and on the binding to the blood constituents of the 18 F-FDG using precipitation with trichloroacetic acid (TCA). EGb was not capable to interfere on the distribution of the 18 F-FDG on the BC and P compartments. However, this extract was capable of interfering significantly (p<0.05) on the fixation of the 18 F-FDG on IF-P (in all the concentrations tested, P<0.05) and IF-BC in 1% TCA concentration from 14.04±1.13 to 10.23±1.92 (40mg/ml, EGb) and to 9.35 ±1.57 (400mg/ml/EGb), in 5% TCA concentration from 14.83±3.78 to 11.15±1.64 (40mg/ml, EGb) and to 10.23±1.6 (400mg/ml, EGb). In conclusion, the analysis of the results indicates that the EGb was not capable to interfere on the distribution of the 18 F-FDG on P and BC compartments, however, alter the fixation of the 18FDG on IF-P and IF-BC.

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confidence: 99%

Influence of a Ginkgo biloba extract on the binding of [F-18]-fluorodeoxyglucose (18F-FDG) on blood constituents

Aleixo¹

2013

Afr. J. Pharm. Pharmacol.

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A perspective on plant origin radiolabeled compounds, their biological affinities and interaction between plant extracts with radiopharmaceuticals

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2015

J Radioanal Nucl Chem

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Ginkgo biloba extract alters the binding of the sodium [123I] iodide (Na123I) on blood constituents

Aleixo

Moreno

Freitas

et al. 2012

Applied Radiation and Isotopes

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Experimental models using radionuclides for assessment of the effects of natural drugs

Abstract: ABSTRACT

Cited by 3 publications

References 12 publications

Influence of a Ginkgo biloba extract on the binding of [F-18]-fluorodeoxyglucose (18F-FDG) on blood constituents

Influence of a Ginkgo biloba extract on the binding of [F-18]-fluorodeoxyglucose (18F-FDG) on blood constituents

A perspective on plant origin radiolabeled compounds, their biological affinities and interaction between plant extracts with radiopharmaceuticals

Ginkgo biloba extract alters the binding of the sodium [123I] iodide (Na123I) on blood constituents

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