Uncaria tomentosa extract: evaluation of effects on the in vitro and in vivo labeling of blood constituents with technetium-99m

Moreno, Silvana Ramos Farías; Carvalho, Jorge José de; Nascimento, Ana Lúcia Rosa; Olej, Beni; Rocha, Emely Kazan; Arnóbio, Adriano; Bernardo-Filho, Mário; Caldas, Luiz Querino de Araújo; Honeycut, Hayden

doi:10.1590/s1516-89132008000700024

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…These results confirm our hypothesis that secondary metabolites of the flavonoid type give the antioxidant characteristic to these extracts. Previous research had demonstrated that the genus Nectandra is rich in metabolites, such as polyphenols, flavonoids, and alkaloids, that confer analgesic, anti-inflammatory, and antioxidant activities (Le Quesne et al, 1980;Filho et al, 2004;Oliveira De Melo et al, 2006;Moreno et al, 2011;Ponci et al, 2015;Espitia Corredor et al, 2016). Additionally, some investigations suggested that some polyphenols have biological activities, such as transcription factors agonists (LXR agonist), BACE inhibition, and anti Aβ aggregation activity, that give the extracts from Nectandra potential action against AD (Park et al, 2004;Ondeyka et al, 2005;Wang and Du, 2009;Paula et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective and antioxidant activities of Colombian plants against paraquat and C2-ceramide exposure in SH-SY5Y cells

Bustos-Rangel

Muñoz-Cabrera²,

Suárez

et al. 2023

Front. Nat. Prod.

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Abnormal production of reactive oxygen species (ROS) has been implicated in the physiopathology of neuronal cell death. Increased ROS levels are associated with exacerbated peptide aggregation, inflammation, and mitochondrial dysfunction, which facilitate the triggering of specific cell death pathways. Antioxidant molecules are potentially useful in the amelioration of neurodegeneration. In this regard, natural products are an invaluable source of antioxidants. Therefore, we investigate the antioxidant and neuroprotective activities of four Colombian angiosperm extracts. Antioxidant activity was evaluated by phytochemical assays using TLC techniques with Dragendorff reagent, ninhydrin, and chloranil in dioxane, NH3, Fast Blue, and FeCl3, together with bioautography using DPPH and β-carotene. In vitro neuroprotective activity, cell death, and ROS accumulation were evaluated by MTT and flow cytometry in the SH-SY5Y cell line exposed to paraquat and C2-ceramide. We found that Zanthoxylum rhoifolium Lam, Zanthoxylum martinicense, Nectandra membranacea, and Nectandra reticulata extracts have antioxidant activity higher than quercetin under a β-carotene bleaching assay and protect SH-SY5Y cells against paraquat and C2-ceramide associated with a reduction in ROS. In conclusion, these extracts have a strong neuroprotective potential, and the precise mechanism requires more evaluation.

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Section: Discussionmentioning

confidence: 99%

Neuroprotective and antioxidant activities of Colombian plants against paraquat and C2-ceramide exposure in SH-SY5Y cells

Bustos-Rangel

Muñoz-Cabrera²,

Suárez

et al. 2023

Front. Nat. Prod.

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“…Interfere na ligação e leitura dos radiocomplexos e leitura dos elementos sanguíneos Estudo in vitro [74] Marcador Na99mTcO4…”

Section: Anticoagulantesunclassified

“…Isso pode diminuir a visualização do órgão, o que pode exigir um procedimento de repetição e aumentar o potencial para erros de diagnóstico [75][76][77][78] . Esse fitoterápico também pode interferir com métodos de estimação de células sanguíneas que utilizam Tc -99m, pois, pode quelar aos íons estanosos e ou pertecnato [74] .…”

Section: Salgueiro (Salix Alba L)unclassified

Possíveis interações medicamentosas de fitoterápicos e plantas medicinais incluídas na relação nacional de medicamentos essenciais do SUS: revisão sistemática

Kirchner¹,

Pelaquin²,

Magalhães³

et al. 2022

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O presente estudo trata-se de uma revisão sistemática sobre as possíveis interações medicamentosas do uso de plantas medicinais e fitoterápicos incluídos na Relação Nacional de Medicamentos Essenciais (RENAME). Para isso, foram pesquisadas as interações entre medicamentos alopáticos e as plantas medicinais: alcachofra, aroeira, babosa, cáscara sagrada, espinheira-santa, garra do diabo, guaco, hortelã pimenta, isoflavona de soja, plantago, salgueiro e unha de gato. Foram identificados inicialmente, 637 artigos, com uma seleção final de 61 artigos, desses os mais encontrados foram revisões de literatura (52%), estudos in vitro (23%), estudos em animais (11%), relatos de caso (7%), estudo descritivo observacional (5%) e ensaio clínico (2%). Verificou-se interações como, diminuição da absorção de medicamentos, interferência com enzimas do citocromo P450 e efeitos sinérgicos levando a toxicidade. Foram descritas diversas interações, tais como: varfarina e anticoagulantes com babosa, garra do diabo, guaco, isoflavonas de soja, plantago e salgueiro; diuréticos com alcachofra, babosa, cáscara sagrada e plantago; corticoides com babosa, cáscara sagrada e plantago; digitálicos ou digitoxinas com babosa, cáscara sagrada e plantago; anti-inflamatórios não esteroidas com garra do diabo e plantago. Verifca-se que o uso de fitoterápicos exige cautela a fim de evitar repercussões graves no que tange a possíveis interações.

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“…Moreover, authors have pointed out that in nuclear medicine, it is essential the understanding and quantification of this phenomenon in order to anticipate the behavior in vivo of radiotracers (Velasques de Oliveira et al, 2010b). In addition, authors have reported that several synthetic (Nigri et al, 2002) and natural medications (Moreno et al, 2007;Moreno et al, 2008a;Moreno et al, 2008b;Moreno et al, 2008c;Souza et al, 2011) are capable of interfering with the biodistribution and/or on the radiolabeling of blood constituents. These considerations show the importance of the studies about the effect of medications on the behavior of the radiopharmaceuticals.…”

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confidence: 99%

Influence of a Ginkgo biloba extract on the binding of [F-18]-fluorodeoxyglucose (18F-FDG) on blood constituents

Aleixo¹

2013

Afr. J. Pharm. Pharmacol.

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Radiopharmaceuticals are used in procedures of nuclear medicine for the diagnosis and treatment of illnesses. Fluorine-18(18 F) is a positron emitter produced in cyclotron. It is used to get 18 fluorodeoxyglucose (18 F-FDG) that is a radiopharmaceutical utilized in the positron emission tomography scan. The aim of this work was to evaluate the in vitro effect of an extract of Ginkgo biloba extract (EGb) on the distribution in blood cells (BC) and plasma (P) compartments and on the binding to the blood constituents of the 18 F-FDG using precipitation with trichloroacetic acid (TCA). EGb was not capable to interfere on the distribution of the 18 F-FDG on the BC and P compartments. However, this extract was capable of interfering significantly (p<0.05) on the fixation of the 18 F-FDG on IF-P (in all the concentrations tested, P<0.05) and IF-BC in 1% TCA concentration from 14.04±1.13 to 10.23±1.92 (40mg/ml, EGb) and to 9.35 ±1.57 (400mg/ml/EGb), in 5% TCA concentration from 14.83±3.78 to 11.15±1.64 (40mg/ml, EGb) and to 10.23±1.6 (400mg/ml, EGb). In conclusion, the analysis of the results indicates that the EGb was not capable to interfere on the distribution of the 18 F-FDG on P and BC compartments, however, alter the fixation of the 18FDG on IF-P and IF-BC.

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Uncaria tomentosa extract: evaluation of effects on the in vitro and in vivo labeling of blood constituents with technetium-99m

Abstract: The influence (in vivo and in vitro)

Cited by 4 publications

References 18 publications

Neuroprotective and antioxidant activities of Colombian plants against paraquat and C2-ceramide exposure in SH-SY5Y cells

Neuroprotective and antioxidant activities of Colombian plants against paraquat and C2-ceramide exposure in SH-SY5Y cells

Possíveis interações medicamentosas de fitoterápicos e plantas medicinais incluídas na relação nacional de medicamentos essenciais do SUS: revisão sistemática

Influence of a Ginkgo biloba extract on the binding of [F-18]-fluorodeoxyglucose (18F-FDG) on blood constituents

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