Radiotherapy, cancer and some anatomical structures related with the pelvic floor: an evaluation of the scientific literature

Fonseca, Adenilson de Souza da; Bernardo-Filho, Mário; Gomes, Roberto Alcântara; Caneca, Rua Frei; Hall, William J.; Keynes, Milton

doi:10.1590/s1516-89132008000700008

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Radiotherapy is, after surgery, the most widely used and effective means of treating cancers, and it is estimated that over 50% of all cancer patients require radiotherapy at some time during their illness. 12,13 It is well known that ionizing radiations induce oxidative stress on target tissues, mainly through the generation of reactive oxygen species (ROS), resulting in imbalance of the prooxidant and antioxidant status/levels in the cells, attack diverse cellular macromolecules such as DNA, lipids, and proteins, eventually inducing cell death. 14 Gamma rays are form of ionizing radiation used in radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

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Radioprotection of 1,2-dimethylhydrazine-initiated colon cancer in rats using low-dose γ rays by modulating multidrug resistance-1, cytokeratin 20, and β-catenin expression

Nabil

Tohamy

et al. 2015

Hum Exp Toxicol

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Ionizing radiation is a widely used therapy for solid tumors. However, high-dose ionizing radiation causes apoptosis, transforms normal cells into tumor cells, and impairs immune functions, leading to the defects in the removal of damaged or tumor cells. In contrast, low-dose radiation has been reported to exert various beneficial effects in cells. This experimental study investigated the effect of γ rays at low dose on the development of colorectal tumor in a 1,2-dimethylhydrazine (DMH)-induced colon cancer. Colorectal tumor model was induced in Wistar rats by subcutaneous injection of DMH (20 mg/kg) once a week for 15 weeks. Starting from zero day of DMH injection, a single low dose of whole-body γ irradiation of 0.5 Gy/week was applied to the rats. A significant reduction in lipid peroxidation, nitric oxide, and elevation in the glutathione content and antioxidant enzyme activity (superoxide dismutase and catalase) were observed after γ irradiation comparing with DMH group. Moreover, γ ray reduced the expressions of multidrug resistance 1 (MDR1), β-catenin, and cytokeratin 20 (CK20) those increased in DMH-treated rats. However, survivin did not change with γ ray treatment. A histopathological examination of the DMH-injected rats revealed ulcerative colitis, dysplasia, anaplasia, and hyperchromasia. An improvement in the histopathological picture was seen in the colon of rats exposed to γ rays. In conclusion, the present results showed that low-dose γ ray significantly inhibited DMH-induced colon carcinogenesis in rats by modulating CK20, MDR1, and β-catenin expression but not survivin expression.

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Section: Introductionmentioning

confidence: 99%

“…Each element decays at a specific rate and gives off energy in the form of γ rays and other radiation. 12 Therefore, the purpose of this study was to investigate the effect of γ rays at low dose on the development of colorectal tumor in DMH-induced rat colon carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Radioprotection of 1,2-dimethylhydrazine-initiated colon cancer in rats using low-dose γ rays by modulating multidrug resistance-1, cytokeratin 20, and β-catenin expression

Nabil

Tohamy

et al. 2015

Hum Exp Toxicol

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Tratamento da mucosite oral radio e quimioinduzida: comparação entre protocolo medicamentoso convencional e tratamentos com lasers em baixa intensidade

Alencar¹

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In this clinical study verified the effects of low intensity laser in the prevention and treatment of oral mucositis radio and/or chemical induced. Thirty one patients with head and neck cancer were selected before being submitted to cancer exclusive radiotherapy or radio and associated chemotherapy. The patients were distributed into three randomly groups as follows: group 1-(control) conventional medicine treatment; group 2conventional medicine treatment and daily lasertherapy as soon as grade two oral mucositis appeared; group 3conventional medicine treatment and daily lasertherapy to be initiated immediately before radiotherapy sessions.The irradiation parameters were: wavelength of 660nm, potency of 100mW, continuous mode, punctual application, 2J energy on thirty predetermined 30 points, with 20s of exposure per point. The control group received medical treatment which consisted in using a set of preventive and therapeutic approach for acute radiation-induced adverse effects. Results were evaluated observing occurrence and grade of oral mucositis, score of pain, loss of body mass, use of nasogastric sound line, internment and interruption of oncologic treatment due to oral mucositis. The results showed that the preventive protocol as used was the most effective in prevention and treatment of oral mucositis and that its daily application contributed in relieving the painful symptomatology so collaborating to maintain and/or bettering the life quality of oncologic patients.

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Radiotherapy, cancer and some anatomical structures related with the pelvic floor: an evaluation of the scientific literature

Cited by 2 publications

References 13 publications

Radioprotection of 1,2-dimethylhydrazine-initiated colon cancer in rats using low-dose γ rays by modulating multidrug resistance-1, cytokeratin 20, and β-catenin expression

Radioprotection of 1,2-dimethylhydrazine-initiated colon cancer in rats using low-dose γ rays by modulating multidrug resistance-1, cytokeratin 20, and β-catenin expression

Tratamento da mucosite oral radio e quimioinduzida: comparação entre protocolo medicamentoso convencional e tratamentos com lasers em baixa intensidade

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