Effect of indomethacin on the pregnant rat

Damasceno, Débora Cristina; Volpato, Gustavo Tadeu; Ferrari, C.; Roldan, Luciana B.; Souza, Maricelma da Silva Soares de

doi:10.1590/s1516-89132008000100010

Cited by 3 publications

(1 citation statement)

References 17 publications

(18 reference statements)

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“…Abnormal Sperm Percent: The sperm was examined and the normal appearance was distinguished from the distorted by the head or tail or both to calculate the abnormal sperm. The same slide was used that was used to calculate the dead and live sperm, and to determine the abnormal appearance of the sperm, the following equation is calculated: (Deformation% = Abnormal number of sperms / Total number of sperms X 100), (Dale and Edler, 1997), (Damascono et al, 2008).…”

Section: Methodsmentioning

confidence: 99%

Sex hormones and sperm parameters of male white rats treated with amlodipine

Wazir

Zubaide

2022

ijhs

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The study aimed to investigate the effect of amlodipine on Sex hormones and sperm parameters in white male rats. The study was conducted in the animal house of the College of Pharmacy/University of Karbala, And on October 31, 2021 until January 30, 2022. Twenty (20) adult white rats, a three-month-old male, with weights ranging from (300-200) g. Male rats were randomly divided into two main groups, the first group was a control group that included (10) rats, It was dosed orally and daily with physiological saline solution (NaCl 0.09%), As for the second group, it was dose it orally the amlodipine at a concentration of (10 mg/kg) for 60 day. study showed a significant decrease (P≤ 0.01) in the sperm concentration in the caudal epididymis And in the percentage of live sperm in the caudal epididymis and sperm motility as well as in the viability of sperm, Also, there was a significant increase (P≤ 0.01) in the percentage of upnormal sperms in the caudal epididymis when compared to the control group. The results of the current study showed a significant decrease (P≤0.01) (P≤0.05) for (Follicle-Stimulating hormone (FSH) and Luteinizing hormone (LH) and Testosterone hormone).

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Section: Methodsmentioning

confidence: 99%

Sex hormones and sperm parameters of male white rats treated with amlodipine

Wazir

Zubaide

2022

ijhs

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Effect of indomethacin on embryo implantation and histomorphology of uterus, ovary, kidney, and liver of rats

Amir,

Yimer,

Hiew

et al. 2023

Saudi Journal of Biological Sciences

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Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats

Volpato

Francia-Farje

Damasceno

et al. 2015

An. Acad. Bras. Ciênc.

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Citrus aurantium L., commonly known as bitter orange, is widely used in folk medicine, but there is little data in the literature about the effects on pregnancy. The aim of the present study was to evaluate the influence of essential oil obtained from fruits of Citrus aurantium on the maternal reproductive outcome and fetal anomaly incidence in rats. Pregnant Wistar rats were randomized into four groups (n minimum = 12 animals/group): G1 = control, G2 to G4 = treated with essential oil from C. aurantium at dose 125, 250 and 500 mg/kg, respectively. Rats were orally treated, by gavage, with plant essential oil or vehicle during pre-implantation and organogenic period (gestational day 0-14). On gestational day 20 the rats were anaesthetized and the gravid uterus was weighed with its contents and the fetuses were analyzed. Results showed that the treated group with 500 mg/kg presented decreased placental weights and placental index, although the treatment with bitter orange essential oil did not show any alteration in maternal reproductive performance, toxicological effect, changes in ossification sites, and malformation index. In conclusion, the treatment of Citrus aurantium essential oil was not teratogenic and did not alter the maternal reproductive outcome.

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Effect of indomethacin on the pregnant rat

Abstract: ABSTRACT

Cited by 3 publications

References 17 publications

Sex hormones and sperm parameters of male white rats treated with amlodipine

Sex hormones and sperm parameters of male white rats treated with amlodipine

Effect of indomethacin on embryo implantation and histomorphology of uterus, ovary, kidney, and liver of rats

Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats

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