Radionuclide imaging of musculoskeletal infection

Palestro, Christopher J.; Love, Charito

doi:10.1590/s1516-89132007000600003

Cited by 7 publications

(11 citation statements)

References 47 publications

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“…BSc is one of the most frequently performed of all radionuclide procedures [11]. It is widely used, relatively cheap, well tolerated and has an accuracy of more than 90% [12]. It is useful in scanning osteonecrosis in SCD patients, one of the main complications of this disease.…”

Section: Bone Scintigraphymentioning

confidence: 99%

Bone Scintigraphy Scanning Safety and Necessity for Silent and Multifocal Osteonecrosis in Sickle Cell Disease

2016

J Hematol Thromb

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Sickle cell disease is a congenital autosomal recessive disease. The predominant pathophysiological feature is vaso cclusion, which leads to acute and chronic complications. Multifocal and silent progressive osteonecrosis over the whole skeleton is one of the major complications of this disorder, requiring follow-up, prophylaxis, and treatment. Bone scintigraphy scanning is widely used, relatively inexpensive, well-tolerated, and has an accuracy of over 90%. MRI is the gold standard imaging technique, however, it has a higher specificity than bone scintigraphy, but it may require contrast dye, which could be nephrotoxic, as sickle cell disease nephropathy is a common complication in such patients. For screening purposes and follow-up of bone integrity, a bone scan can detect silent and multifocal osteonecrosis without the need for contrast dye, which makes it a safe and necessary tool for bone complication follow-up before the osteonecrotic asymptomatic joints develop to advance stages without being noticed by the patient.

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Section: Bone Scintigraphymentioning

confidence: 99%

Bone Scintigraphy Scanning Safety and Necessity for Silent and Multifocal Osteonecrosis in Sickle Cell Disease

2016

J Hematol Thromb

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“…A serious complication of bacterial endocarditis is the mycotic aneurysm. The patient with a suspected mycotic aneurysm is best managed by combining anatomic imaging, to localize the aneurysm, with labeled leukocyte imaging, to determine whether or not infection is present (Palestro et al, 1999). Labeled leukocyte imaging is the radionuclide procedure of choice for diagnosing prosthetic vascular graft infection.…”

Section: Cardiovascular Infectionmentioning

confidence: 99%

“…The specificity is more variable ranging from 53% to 100%. False positive results are associated with perigraft hematomas, graft thrombosis, bleeding, and pseudo-aneurysms (Palestro et al, 1999).…”

Section: Cardiovascular Infectionmentioning

confidence: 99%

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Radionuclide imaging of infection: what the future holds

Palestro

2008

Braz. arch. biol. technol.

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Nuclear Medicine plays an important role in the evaluation of patients suspected of harboring infection. Gallium imaging is especially useful for opportunistic infections and spinal osteomyelitis. In vitro labeled leukocyte imaging is the current radionuclide gold standard for imaging most infections, in immunocompetent patients, including cardiovascular, postoperative, and musculoskeletal infections (except spinal osteomyelitis). Several in-vivo

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“…32 The use of the combination of dynamic bone scintigraphy (3 phases) + labelled leucocytes is accepted as a method which has good diagnostic efficacy (between 79 and 100%) for infectious processes in the peripheral skeleton at the clinical level. 33,34 However, the efficacy of this strategy decreases in the presence of:…”

Section: Introductionmentioning

confidence: 99%

18FDG-PET: a new diagnostic approach in hip prosthesis infection

García-Barrecheguren¹,

Fraile²,

Santana³

et al. 2007

Revista Española de Medicina Nuclear (English Edition)

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Infection following hip arthroplasties can present a diagnostic challenge. No test is 100 % sensitive and 100% specific; this prospective study was undertaken to evaluate the utility of FDG-PET imaging for diagnosing infected joint replacements. 24 hip joint replacements were studied prospectively and we have complete diagnoses with clinical signs and symptoms, laboratory tests, radiography, joint aspiration, radionuclide imaging including FDG-PET, and histopathologic examination. 11 of 24 prostheses were infected. The sensitivity and specificity of PET for detecting infection associated with prostheses were 64.3% and 64.7% respectively, in our study. FDG imaging is not useful in patients with suspected prosthetic infection as a screening test.

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Radionuclide imaging of musculoskeletal infection

Abstract: ABSTRACT

Cited by 7 publications

References 47 publications

Bone Scintigraphy Scanning Safety and Necessity for Silent and Multifocal Osteonecrosis in Sickle Cell Disease

Bone Scintigraphy Scanning Safety and Necessity for Silent and Multifocal Osteonecrosis in Sickle Cell Disease

Radionuclide imaging of infection: what the future holds

18FDG-PET: a new diagnostic approach in hip prosthesis infection

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