Embryo development alteration in rats treated with lapachol

Abstract

Lapachol, a naphthoquinone extracted from plants of the genus

Effect of Rythmol (propafenone HCl) administration during pregnancy in Wistar rats

“…The absence of preimplantation loss in the treated group could be attributed to the treatment period, which began at 5 days after conception, although the preimplantation phase lasts from the first to the fourth day of pregnancy. [39] The lack of significant alteration in the treated mean number of resorbed fetuses was in agreement with Ognio et al [46] who examined the influence of procainamide HCl, which acts as an antiarrhythmic drug, in timed-pregnant CD-1 mice from GD 12 to GD 18 at a dose of 50 mg/kg/day and found no significant change in the percentage of resorbed fetuses.…”

“…This was in accordance with a previous report Ujházy et al [ 38 ] that studied the teratological effects of stobadine, which has antiarrhythmic and antihypnotic activity on Institute of Cancer Research (ICR) mice, and found that the frequent oral dose (61.0 mg/kg) on Days 4–16 of conception, of stobadine, which was administered as a dipalmitate salt (DP 1031), caused a major fall in the number of implantation sites. As the implantation period lasts from the fifth to the seventh day of pregnancy [ 39 ] and the fifth day was the first day of medication administration, these data suggest that propafenone HCl may affect the early stages of embryonal development in rats.…”

Cinnamaldehyde mitigates placental vascular dysfunction of gestational diabetes and protects from the associated fetal hypoxia by modulating placental angiogenesis, metabolic activity and oxidative stress

“…At the fifth experimental week, all rats were mated with males overnight. In the morning, the positive vaginal smear revealed the zero gestational day (rats with negative vaginal smears were omitted in order to keep the FSD/STZ-model criteria of feeding FSD for six weeks before STZ injection at, exactly, the seventh day of gestation; the end of the implantation phase of the embryo [36]). The pre-gestational period is the time before mating, while that after mating is the gestational period.…”

Lapachol: An overview

“…A large number of therapeutic activities have been attributed to lapachol and its derivatives such as the prevention against Schistosoma mansoni cercarial for skin penetration. It was also effective against Biomphalaria glabrata, 62 embryo alteration in rats, 62 and showed antioxidant, 63 cytotoxic (in human Promyelocytic Leukemia HL-60 cell line), 64 analgesic, 65 and antipsoriatic activity. 65 In conclusion, the Phytochemical Database housed at the U.S. Department of Agriculture has documented lapachol as being anti-abscess, anticarcinomic, anti-edemic, anti-inflammatory, antimalarial, antiseptic, antitumor, antiviral, bactericidal, fungicidal, insectifugal, pesticidal, protisticidal, respiradepressant, schistosomicidal, termiticidal, and viricidal.…”