Antimicrobial effectiveness of maleimides on fungal strains isolated from onychomycosis

Abstract

This study aimed to analyze the effectiveness of maleimides as inhibitors on the growth of fungal strains isolated from onychomycosis by the solid medium diffusion procedure. The results showed a promising antifungical activity of the assayed maleimides with formation of fungal growth inhibition halos oscillating between diameter 10 and 23mm. MIC was 100µg

Synthesis of azatricyclodiones & octahydro-benzo[f]isoindoles and their antimicrobial evaluation

“…General method for the preparation of 1-aminomethyl-4-(substituted)phenyl-10-oxa-4-aza-tricyclo[5.2.1.0 2,6 ] dec-8-ene-3,5-dione (2,4,6,8,10) and 4,8-diamino methyl-4,9-5,8-diepoxy-2-(susbstituted)phenyl3a,4,4a,5,8,8a,9,9a-octahydro-benzo[f]isoindole (3, 5, 7, 9, 11, and 12):. To the solution of appropriate starting maleimide (1a -1 g) (5.78 mmol) in toluene (7 mL), at 808C and 1 equivalents of furfuryl amine (0.50 mL, 5.78 mmol) for 2 -3 h till the complete disappearance of starting material (TLC).…”

“…1-(4-Chloro-phenyl)-3-(3,5-dioxo-4-phenyl-10-oxa-4-aza-tricyclo[5.2.1.0 2,6 ]dec-8-en-1-ylmethyl)-urea (13 Thus reaction of N-phenyl maleimides (1a -1e) with one equivalent of furfuryl amine in benzene at 808C in toluene led to the formation of respective azatricyclodiones 2 [10], 4, 6, 8 and 10 as major products in varying yields along with minor amount of octahydro-benzo[f]isoindoles 3, 5, 7 and 9 with maleimides 1a -1d. The respective octahydro-benzo[-f]isoindole could not be detected during reaction of furfuryl amine with maleimide 1e.…”

“…Moreover, maleimides, themselves are well known as antifungal agents and many of them have potential as drugs [4 -6]. Protein kinases are implicated in a number of biological processes and are the hot targets to explore new drugs and it is established that maleimides inhibit protein kinases [6]. Furan ring on the other hand is very common in natural products and pharmaceuticals.…”

Synthesis and evaluation of antimicrobial activity of cyclic imides derived from phthalic and succinic anhydrides

“…Their hydrophobicity and neutral structures enable them to easily cross biological membranes( 1 2 3 4 5 6 ). These molecules are reported to exhibit valuable biological effects including antifungal( 7 8 9 ), antibacterial( 10 11 12 13 14 ) anticancer, apoptosis induction( 6 15 ), anti-inflammatory( 16 ), androgen receptor antagonists( 3 ), anxiolytic, and anticonvulsant( 2 3 ). Structure activity relationship studies of these systems in some literatures revealed that incorporation of heterocyclic moiety in the imide portion or linkage with nitrogen improve their anti-inflammatory and antitumor activities.…”

“…have reported antifungal effectiveness of 3,4-dichloro-N-phenyl-alkyle-maleimide derivatives. Compounds 3, 4-dichloro-N-phenyl-methyl-maleimide and 3,4-dichloro-N-phenyl-propilmaleimide displayed antifungal activities with MIC of 100 μg/mL against fungal strains( 7 ). Sultana, et al .…”