Influence of tetracycline in the hepatic and renal development of rat's offspring

Abstract

This study aimed on evaluating the possible effects of tetracycline administered to rats on the tenth day of pregnancy, on kidney and liver development of their offspring. The liver showed vacuolization, necrosis, inflammation and sinusoidal dilatations, more evident in the newborn. Mitosis, early increase of Kupffer cells population and hipertrophy of hepatocytes with greater synthesis of glycogen were present on the tenth and twentieth days of life. The kidney showed slight tubular vacuolizations and necrosis, more proeminent in the newborn, as well as signs of tubular regeneration on the tenth and twentieth days. These results suggested that the organs studied went through several transitory morphological changes during development but presented signs of regeneration along the first days of life.<br>O objetivo deste estudo foi avaliar os possíveis efeitos da tetraciclina administrada a ratas, no décimo dia de gestação, no desenvolvimento hepático e renal de seus filhotes. O fígado mostrou vacuolização, necrose, inflamação e dilatação sinusoidal mais evidente em recém-nascidos. Mitoses, aumento precoce da população de células de Kupffer e hipertrofia de hepatócitos com maior síntese de glicogênio estavam presentes no décimo e vigésimo dias de vida. O rim mostrou vacuolização tubular e necrose discretas, mais evidentes nos recém-nascidos, assim como sinais de regeneração tubular no décimo e vigésimo dias. Esses resultados sugeriram que os órgãos estudados sofreram alterações morfológicas transitórias durante o desenvolvimento, mas apresentaram sinais de regeneração ao longo dos primeiros dias de vida

Influence of doxycycline administration on rat embryonic development during organogenesis

“…In contrast, both the mother and the baby cannot be harmed by the inadequate treatment of infections. [ 47 ] The present results showed that fetal liver from both treated groups revealed degeneration of hepatic tissue, fatty degeneration, congested central vein, necrosis, and lymphocyte invasion. In addition, the liver of the fetuses showed fatty changes, hemolysis of the blood in sinusoidal spaces, and central vein dilatation with focal hemosiderosis, necrosis, and pyknotic nuclei.…”

“…Another report showed that TC can cause chromosomal abnormalities. [ 47 ] In addition, the presence of mitochondrial rich placenta during pregnancy elevates oxidative stress [ 53,54 ] and alters many physiological and metabolic functions. [ 55 ] Over and above this, Sekhon et al [ 56 ] demonstrated that oxidative stress influences multiple physiological processes, from oocyte maturation to fertilization, embryo development, and pregnancy.…”

Modulatory and regenerative potential of transplanted bone marrow-derived mesenchymal stem cells on rifampicin-induced kidney toxicity

“…This may likely cause kidney failure due to prolonged rifampicin treatment of tuberculosis, as is clearly seen in our findings. [44] ; reported that rat offspring from parents that receive antibiotic treatment reveal some symptoms of tubular vacuolation and necrosis, and these symptoms are more pronounced in the newborn rats, although some signs of tubular restoration are also seen at 10 and 20 days after treatment. Our result regarding the rifampicin plus stem cell-treated kidney showed an apparently normal histological architecture of renal corpuscle with a well-formed glomerular tuft surrounded by Bowman's space.…”

Tetracycline and toxicity induced

“…11 Toxicity of TCs has proven by long use of this antibiotic or as high dose responses in which kidney and liver are seriously affected. [12][13][14] In their studies, they concluded that the renal side effects of tetracycline showed an increase in Fanconi's syndrome and blood urine nitrogen (BUN). In patients with pre-existing renal impairment, tetracycline may cause azotemia, hyperphosphatemia, and acidosis.…”