Determinação de haplótipos do gene beta S em pacientes com anemia falciforme

Haplotype of the βS-globin cluster in patients with sickle cell anemia at a University Hospital in the Triangulo Mineiro, Minas Gerais

“…In relation to genotypes, the CAR/CAR predominated (50.8%), followed by CAR/ATP, CAR/BEN and BEN/BEN with a similar frequency (13.1%). These findings are consistent with those found by Cabral et al 8 in Rio Grande do Norte with 58.5% for the CAR/CAR and 16.9% for the CAR/BEN. However, our results are not similar to those described by Belisário et al 12 in Belo Horizonte, where the frequencies were 39.4% for CAR/CAR, 33.2% for CAR/BEN, 23.6% for BEN/BEN, 0.9% for CAR/ATP, 0.9% for BEN/ATP and 0.9% for BEN/Arabian-Indian.…”

“… 3,4 In Rio de Janeiro, the CAR (54%) was more frequent than the BEN (44.6%), 5 similar to what was observed in Porto Alegre, 6 where the frequency was 79.6% for the CAR and 18.4% for Benin. In Pernambuco the frequency of CAR was 79.1%, 7 in Rio Grande do Norte 75.5% 8 and Fortaleza it was 66.2%. 9 The CAM haplotype in this study showed a low rate (0.8%) similar to the rate described in Salvador (BA), Belém (PA), and Pernambuco, with frequencies of 1.2%, 1.3% and 0.8%, respectively.…”