Diferenciação das anemias microcíticas utilizando a determinação do RDW

Grotto, Helena Zerlotti Wolf

doi:10.1590/s1516-84842008000200003

Cited by 3 publications

(4 citation statements)

References 6 publications

(7 reference statements)

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“…Hephaestin is a ferroxidase that converts Fe 2+ to Fe 3+ for incorporation into transferrin. 13 The hephaestin mRNA expression was lower in animals that received a high fat diet and a standard diet with chia. This result is expected, leading Data presented as mean ± standard deviation.…”

Section: Resultsmentioning

confidence: 96%

“…to lower oxidation of iron and consequently less absorption and iron accumulation in enterocytes and macrophages. 13 A study that evaluated animals fed with a standard diet and a high fat diet found decreased hephaestin mRNA expression in rats fed with a high fat diet when compared with standard animals. 40 The systemic iron homeostasis is achieved by regulating iron absorption and storage and by recycling mechanisms.…”

Section: Resultsmentioning

confidence: 99%

“…Ferritin, in turn, is responsible for iron storage. 13 Intake of a high fat diet reduces the action of PPARs and increases iron transport genes, interfering therefore in iron metabolism. 14 Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors that activate the transcription of genes involved in many different processes, including lipid metabolism and inflammation.…”

Section: Introductionmentioning

confidence: 99%

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A high fat diet does not affect the iron bioavailability in Wistar rats fed with chia and increases gene expression of iron metabolism proteins

et al. 2016

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This study evaluated the effect of chia on the iron bioavailability and gene expression of proteins involved in iron metabolism in animals fed with a high fat diet and a standard diet. Four experimental groups were tested (n = 8): standard diet + ferrous sulfate (SD + FS), standard diet + chia (SD + C), high fat diet + ferrous sulfate (HFD + FS), high fat diet + chia (HFD + C). The hemoglobin gain, hemoglobin regeneration efficiency, biological relative value of HRE, serum ferritin and transferrin, liver iron concentration and gene expression of proteins were evaluated. The SD + C group showed lower transferrin expression when compared to the control group. The control group showed serum transferrin concentration higher than the other groups. Serum ferritin and liver iron concentration did not differ among the animals that received chia ferritin and hephaestin expression was lower in experimental groups when compared with the control group. The peroxisome proliferator activated receptor expression was higher in animals fed with SD + C than in the control group. The expression of duodenal cytochrome B and divalent metal transporter 1 in the HFD + C group was higher and ferroportin was lower in the groups containing chia. Animals fed with chia showed similar iron bioavailability compared to animals fed with ferrous sulfate.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A high fat diet does not affect the iron bioavailability in Wistar rats fed with chia and increases gene expression of iron metabolism proteins

et al. 2016

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“…O RDW (red cell distribuition width) é medido como um coeficiente de variação da distribuição das hemácias, ou seja, é um indicativo do grau de anisocitose das hemácias expresso em porcentagem (GROTTO, 2008). Segundo Rapaport (1996), o RDW é determinado dividindo o desvio padrão do VCM pelo VCM e multiplicando por 100, convertendo-se assim o valor em porcentagem.…”

Section: Introductionunclassified

Relação Entre Os Valores Do VCM E Do RDW-Cv Em Hemogramas De Pacientes Atendidos No Laboratório De Análises Clínicas Do Hospital Das Clínicas Em Itaperuna-Rj

et al. 2015

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RESUMOOs índices hematimétricos são uma importante ferramenta de auxílio no diagnóstico de diversas enfermidades como nas anemias. Com o objetivo de analisar as correlações de VMC e do RDW-CV entre faixa etária e sexo, bem como avaliar a relação entre o VCM e o aumento ou diminuição do RDW-CV, foi realizada coleta dos dados entre 318 pacientes atendidos no ambulatório do Laboratório de Análises Clínicas do Hospital das Clínicas, para fins de utilidade diagnóstica dos indicadores automatizados de anisocitose diante da presença ou ausência de alteração do VCM. Foram analisados estatisticamente os dados de correlação entre VCM e de RDW-CV entre faixa etária e sexo com o teste F. Já para os grupos de VCM -Macrocítico, Normocítico e Microcítico -com relação ao RDW-CV, utilizou-se a correlação de Pearson e teste t-Studant. Não houve diferença significativa com relação ao sexo para o índice de RDW-CV, apenas para o VCM. A análise realizada na determinação do VCM pelas faixas etárias mostrou diferença significativa apenas entre os indivíduos de 18 a 59 anos com os de até 10 anos e os de 11 a 17 anos. Com relação ao RDW-CV todas as relações apresentaram diferença significativa entre si, exceto a estabelecida entre os de 11 a 17 anos com os de 18 a 59 anos. Os testes sobre os grupos de VCM mostrou significativa correlação apenas nos grupos microcítico e macrocítico. No entanto, todos os grupos mostraram resultado significativo no teste t-Studant.Palavras-chave: Índices hematimétricos; anemia; sangue; eritrócitos. ABSTRACTThe red blood cell rates are an important tool to help the diagnosis of several diseases such as anemia. In order to analyze the correlation between MCV and RDW-CV among age and gender, as well as to assess the relationship between MCV and RDW-CV increasing or reduction, it was performed a data collection among 318 patients treated at the Clinical Laboratory Analysis ambulatory of Hospital Clinics, for the diagnostic purpose of the anisocytisis automated indicators before the presence or absence of MCV change. It was statically assessed the correlation data between MCV and RDW-CV among age and gender with the F test. For the MCV groups -Macrocytic, Normocytic and Microcytic -in relation to RDW-CV it was used the Pearson correlation and the Student-t test. There was no significant difference in relation to gender to the RDW-CV rate, only to MCV. The assessment performed in the MCV determination by age showed significant difference only among the subjects between 18 to 59 years old with the subjects up to 10 years old and the ones between 11 to 17 years old. Regarding the RDW-CV, all relationships showed a significant difference among them, except the one established among the subjects between 11 to 17 years old with the ones between 18 to 59 years

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The effect of combining green iron nanoparticles and algae on the sustainability of broiler production under heat stress conditions

Almeldin,

Eldlebshany,

Elkhalek

et al. 2024

Front. Vet. Sci.

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BackgroundNatural feed additives in broiler feed contribute to the overall health, productivity, and economic viability of broiler chickens while meeting consumer demands and preferences for natural products. The purpose of this research was to determine the effect of green iron nanoparticles (Nano-Fe) and Halimeda opuntia supplementation in broiler diets on performance, ammonia excretion in excreta, Fe retention in tissues and serum, carcass criteria, and meat quality under hot environmental conditions.MethodsA total of 256 one-day-old male Ross 308 broiler chicks were randomly assigned to one of four feeding treatments for 42 days. Each treatment had eight replications, with eight chicks per replicate. The treatments were Negative control (CON), positive control (POS) supplemented with 1 g/kg Halimeda opuntia as a carrier, POS + 20 mg/kg Nano-Fe (NFH1), POS + 40 mg/kg Nano-Fe (NFH2).ResultsWhen compared to CON and POS, dietary Nano-Fe up to 40 mg/kg enhanced (p < 0.001) growth performance in terms of body weight (BW), body weight gain (BWG), and feed conversion ratio (FCR). Nano-Fe had the highest BWG and the most efficient FCR (linear, p < 0.01, and quadratic, p < 0.01) compared to POS. Without affecting internal organs, the addition of Nano-Fe and POS enhanced dressing and reduced (p < 0.001) abdominal fat compared to control (CON). Notably, the water-holding capacity of breast and leg meat was higher (p < 0.001), and cooking loss was lower in broilers given Nano-Fe and POS diets against CON. In comparison to POS, the ammonia content in excreta dropped linearly as green Nano-Fe levels increased. When compared to CON, increasing levels of Nano-Fe levels boosted Fe content in the breast, leg, liver, and serum. The birds fed on POS showed better performance than the birds fed on CON.ConclusionGreen Nano-Fe up to 40 mg/kg fed to broiler diets using 1 g/kg Halimeda opuntia as a carrier or in single can be utilized as an efficient feed supplement for increasing broiler performance, Fe retentions, carcass characteristics, meat quality, and reducing ammonia excretions, under hot conditions.

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Diferenciação das anemias microcíticas utilizando a determinação do RDW

Cited by 3 publications

References 6 publications

A high fat diet does not affect the iron bioavailability in Wistar rats fed with chia and increases gene expression of iron metabolism proteins

A high fat diet does not affect the iron bioavailability in Wistar rats fed with chia and increases gene expression of iron metabolism proteins

Relação Entre Os Valores Do VCM E Do RDW-Cv Em Hemogramas De Pacientes Atendidos No Laboratório De Análises Clínicas Do Hospital Das Clínicas Em Itaperuna-Rj

The effect of combining green iron nanoparticles and algae on the sustainability of broiler production under heat stress conditions

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