Post-transfusion red cell alloimmunisation in patients with acute disorders and medical emergencies

Santos, Francisco W. R.; Magalhães, Sílvia Maria Meira; Mota, Rosa Maria Salani; Pitombeira, Maria Helena

doi:10.1590/s1516-84842007000400009

Cited by 26 publications

(33 citation statements)

References 13 publications

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“…Santos 13 showed a similar result, revealing a frequency of 93.33% of alloimmunized women with a history of pregnancy. Natukunda 14 , in turn, revealed that only 62.5% of the women who produced alloantibodies had previous pregnancies.…”

Section: Alloimmunized N (%)mentioning

confidence: 56%

“…Although nulliparity is indicated as a breast cancer risk among women 13 , our study showed that the vast majority of alloimmunized women had a history of pregnancy (92.5%). Santos 13 showed a similar result, revealing a frequency of 93.33% of alloimmunized women with a history of pregnancy.…”

Section: Alloimmunized N (%)mentioning

confidence: 59%

“…Among the alloimmunized patients, we observed that this time ranged from 5 days to 8 months, whereas in nonalloimmunized patients, the observed time ranged from 1 day to 24 months. In the study carried out by Santos 13 , the time for alloantibody production ranged from 3-97 days, with an average time of 20.88 days. Schonewille 16 observed that 16.8% of the patients became alloimmunized within 14 days after the transfusions and 2.3% produced alloantibodies within a maximum of 3 days, with anti-E as the most common antibody (42.8%).…”

Section: Alloimmunized N (%)mentioning

confidence: 99%

See 2 more Smart Citations

Analysis of the erythrocyte alloimmunization profile of women with breast cancer at the National Cancer Institute

Costa¹,

Santos²,

Calado³

et al. 2017

Rev. Bras. Mastol. (Impr.)

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Section: Alloimmunized N (%)mentioning

confidence: 56%

Section: Alloimmunized N (%)mentioning

confidence: 59%

Section: Alloimmunized N (%)mentioning

confidence: 99%

See 1 more Smart Citation

Analysis of the erythrocyte alloimmunization profile of women with breast cancer at the National Cancer Institute

Costa¹,

Santos²,

Calado³

et al. 2017

Rev. Bras. Mastol. (Impr.)

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“…A maior ocorrência de aloanticorpos foi contra os antígenos dos sistemas Rh e Kell, fato que é de acordo com outros autores, pois ambos os sistemas contêm antígenos altamente imunogênicos (FABRON, 2001;AMEEN, 2009;PINTO, 2011;MILLER, 2012;SCHONEWILLE, 2006;SCHONEWILLE, 2009;TORMEY, 2008;SANTOS, 2007;NATUKUNDA, 2010).…”

Section: Discussionunclassified

“…Não se observou qualquer correlação entre aloimunização e os diferentes tipos sanguíneos do sistema ABO, à semelhança de outros autores (SANTOS, 2007;ALVES, 2012).…”

Section: Discussionunclassified

Aloimunização Eritrocitária Em Pacientes Com Anemia Falciforme Atendidos No Hemocentro De Caruaru, Pernambuco, Brasil

et al. 2018

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Objetivos: A aloimunização eritrocitária é um problema grave em pacientes que recebem transfusões, principalmente no tratamento das hemoglobinopatias, como a anemia falciforme. Os objetivos desse trabalho são estabelecer a frequência da aloimunização eritrocitária em pacientes com anemia falciforme e apontar os fatores envolvidos na aloimunização. Métodos: Estudo descritivo transversal retrospectivo de prevalência, sendo levantadas informações sobre aloimunização e fatores associados, em pacientes com anemia falciforme atendidos pelo Hemocentro de Caruaru, entre janeiro de 1987 a dezembro de 2012. As informações foram obtidas a partir da consulta a dados no sistema de prontuários médicos do Hemocentro, tabuladas em planilhas do programa Excel 2007 (Microsoft Office®) e analisadas estatisticamente através do software R, utilizando o Teste Exato de Fisher e OddsRatio. Resultados: A produção de anticorpos irregulares foi identificada em 11 pacientes, representando uma taxa de aloimunização de 34%. Os anticorpos encontrados foram: 05 anti-C (25%), 05 anti-E (25%), 03 anti-K (15%), 01 anti-D (5%), 01 anti-Cw (5%), 01 anti-Fya (5%), 01 anti-Jka (5%), 01 anti-S (5%), 01 anti-Lea (5%) e 01 anti-Leb (5%). Observou-se que indivíduos com idade acima de 30 anos e pacientes que receberam acima de 10 concentrados de hemácias tiveram maior risco em desenvolver aloanticorpos. Conclusão: Transfusões de hemácias continuam sendo essenciais para o tratamento de complicações da anemia falciforme. A realização da fenotipagem eritrocitária poderá contribuir para reduzir a alosensibilização e consequentemente o número de reações transfusionais hemolíticas, aumentando a segurança transfusional e influenciando na qualidade de vida destes pacientes.

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Methods for blood group antigens detection: cost-effectiveness analysis of phenotyping and genotyping

Quirino

Colli

Macedo

et al. 2019

Hematology, Transfusion and Cell Therapy

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BackgroundAlloimmunization is a major problem in transfusion practice due to the clinical complications of the patients and the difficulty of choosing a unit of compatible blood product. Serological methods are widely used in blood banks, but they not always determine the phenotype. Thus, genotyping is an important complement to the serology tool as it allows one to predict the phenotype from deoxyribonucleic acid (DNA) with high accuracy.ObjectiveTo compare the centrifugation gel, microarray, Restriction Fragment Length Polymorphismone PCR (PCR-RFLP) and Sequence-Specific Primer PCR (PCR-SSP) techniques, in terms of cost, reaction time and reliability of the results.MethodsThe RHCE, Kidd, Kell and Duffy blood group systems were chosen to determine the approximate cost of each technique, considering the reagents used in both methods and considering only one sample. The time required for the development of each reaction was obtained at the Maringa Regional Blood Center and Immunogenetics Laboratory at the State University of Maringa. Data from Microarray reactions were obtained at the Campinas Blood Center. The results of phenotyping and genotyping of the 16 samples were compiled in a spreadsheet and compared.ResultsThe PCR-SSP was more economical compared to other methods, and the serological method was faster than the molecular methods. However, all methods proved to be effective and safe in the detection of erythrocyte antigens.ConclusionAnalyzing the advantages and limitations of the molecular and serological methods tested in this study, we note that both are important and complementary. However, the choice of a methodology depends on the reality and needs of each health service.

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Post-transfusion red cell alloimmunisation in patients with acute disorders and medical emergencies

Abstract: Alloimmunisation following red cell transfusion is a complication in patients with Rev. bras. hematol. hemoter. 2007;29(4):369-372.

Cited by 26 publications

References 13 publications

Analysis of the erythrocyte alloimmunization profile of women with breast cancer at the National Cancer Institute

Analysis of the erythrocyte alloimmunization profile of women with breast cancer at the National Cancer Institute

Aloimunização Eritrocitária Em Pacientes Com Anemia Falciforme Atendidos No Hemocentro De Caruaru, Pernambuco, Brasil

Methods for blood group antigens detection: cost-effectiveness analysis of phenotyping and genotyping

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