Aloimunização após transfusão de concentrado de hemácias em pacientes atendidos em um serviço de emergência

Analysis of the erythrocyte alloimmunization profile of women with breast cancer at the National Cancer Institute

“…This result is similar to Alves's findings 11 , in which 29.41% of the alloimmunized patients had previously received transfusions. In our study, alloimmunized individuals received between 1 and 7 transfusions of red blood cells, with a mean of 3.18 transfusions per patient, which is in agreement with the literature 6,12 . On the other hand, we observed that the proportion of alloimmunized patients receiving more than 5 transfusions was not statistically significant (p = 0.8676) compared to non-alloimmunized patients, since their values were equivalent (18.2 and 18.5%, respectively).…”

“…A similar result was obtained in a 20-year retrospective multicenter study with alloimmunized, non-chronically transfused patients, in which 80 individuals (57%) were sensitized after receiving an average of 2 red cell units. 12 This result shows that alloimmunization in our study had no correlation with the number of transfusions received at the institution, but with the transfusion history. This finding reinforces a possible prevalence of preformed alloantibodies in this group of cancer patients.…”

“…However, in our study, one fact draws a lot of attention. Although there was no statistically significant difference (p = 0.8135), this result is exactly the opposite of what was expected, since pregnancies are an important cause of alloimmunization in women 1,[7][8][9][10]12,14,15 . Therefore, we consider this a casual result.…”

Irregular Antibodies Identified Previously In Blood Transfusions: A Review Of The 21st Century

“…Complementarily, hemolysis occurs in the vascular bed, leading to hepatic impairment leading to an increase in plasma hemoglobin and saturation of the hepatoglobin transport protein (HARMENING p. 179, 2006). When Kell system antigens are present in donor blood and red blood cells are transfused in patients with negative Kell antigen, immediate, late hemolytic reactions and erythrocyte sensitizations occur (BORDIN, 2007).…”

“…This is because erythrocyte antigens are structures that are located on the erythrocyte membrane and detected by alloantibodies. The incidence of irregular antibodies is related to RBC transfused without phenotyping, the importance of which is related to the ability of the antigen to induce and react to an immune response when the subject's immune system is compromised due to the advancement of the disease, which reduces the immunological components exposing the patient to erythrocyte sensitization (BORDIN, 2007).…”