Acidente vascular cerebral e outras complicações do sistema nervoso central nas doenças falciformes

Ângulo, Ivan L.

doi:10.1590/s1516-84842007000300013

“…In young adult males, 5 to 10% suffer from priapism and 45% present some degree of impotence later in life. [6][7][8][9][10] Most prevalent clinical complications in patients with sickle cell disease from a medium-sized town in Minas Gerais, Brazil ment, the pilot study data were not considered in this analysis. Out of the 83 patients elected for the interview, four were excluded because they moved away from Divinópolis, 14 were considered lost, eight were not found, and four had died.…”

Section: Methodsmentioning

confidence: 99%

Most prevalent clinical complications in patients with sickle cell disease from a mediumsized town in Minas Gerais, Brazil

Alencar¹,

Carneiro²,

Guimarães³

et al. 2015

Revista Médica De Minas Gerais

2

0

1

View full text Add to dashboard Cite

Introduction: the patient with sickle cell anemia presents many clinical complications during his lifetime, which affect his quality of life. Objective: to learn about the profile of the patient with drepanocytosis and its most frequent clinical complications and estimate the prevalence of chronic ulcers in these patients. Methods: this was a cross-sectional study including all patients with sickle cell anemia registered at the Hemominas Foundation in Divinópolis, Minas Gerais. Results: repeated infections and pulmonary and hepatobiliary complications were the most frequent complications and 5% of the patients presented active leg ulcers at the time of the study. Conclusion: there is a great variety in the presentation of the disease among patients, which requires a standardization of protocols for services, improved training of health network professionals, and training of families for better monitoring their patients. RESUMOIntrodução: o paciente portador de anemia falciforme apresenta durante sua vida diversas complicações clínicas que afetam muito sua qualidade de vida. Objetivo: conhecer o perfil do paciente com drepanocitose e de suas complicações clínicas mais frequentes e estimar a prevalência de úlceras crônica nesses pacientes. Métodos: trata-se de estudo transversal incluindo todos os portadores de anemia falciforme cadastrados na Fundação Hemominas de Divinópolis, Minas Gerais. Resultados: as infecções de repetição, complicações pulmonares e hepatobiliares foram as mais frequentes e 5% dos pacientes apresentavam úlcera de perna ativa no momento da pesquisa. Conclusão: há grande variedade na apresentação da doença entre seus portadores, sendo necessária padronização de protocolos pelos serviços, melhor capacitação da rede de saúde, bem como do preparo das famílias para que haja melhor acompanhamento dos doentes.

show abstract

“…Esses achados são corroborados por estudos de RM que mostram altas porcentagens de oclusão distal dos grandes vasos. A combinação de dilatação arterial e de suporte elástico fraco aumenta as chances de AVC hemorrágico 33,34 .…”

Section: Ave E Anemia Falciformeunclassified

Stroke in children

Filho¹,

Carvalho²

2009

View full text Add to dashboard Cite

Objectives: To summarize 1) the definitions and epidemiological features of stroke in children; 2) the main risk factors that can lead to stroke in pediatrics and neonatology; 3) the main pathophysiological features involved in the genesis of brain injury in stroke; 4) the clinical manifestations and imaging diagnosis; and 5) the latest recommendations concerning the support measures, treatment, and prophylaxis of stroke in children.Sources: A review of the literature published in PubMed, EMBASE, and SciELO databases using the search terms stroke, pediatrics, and neonatology was performed, including relevant references from the chosen texts. Summary of the findings:Stroke in children are rare conditions, with incidence rates among two and eight per 100,000 children up to 14 years, and most cases show an underlying disease such as heart diseases, prothrombotic conditions, sickle-cell disease, and vascular malformations. There are no specific guidelines currently in place for the treatment of stroke in children, although central elements include support treatment, monitoring, and anticoagulation as secondary prevention in certain cases. Prognosis depends on the extent of brain damage and the underlying disease but recurrence rates are high in most cases. Conclusions:Early diagnosis of stroke in children is very important and pediatricians should be aware of the lack of specificity of the symptoms to avoid late sequelae and improve life quality.J Pediatr (Rio J). 2009;85(6):469-479: Stroke, pediatrics, neonatology, intensive care, anticoagulants. ResumoObjetivos: Listar 1) as definições e características epidemiológicas de acidentes vasculares encefálicos (AVE) em crianças; 2) os principais fatores de risco para a ocorrência de AVE em pediatria e neonatologia; 3) as principais características fisiopatológicas para a ocorrência de lesão cerebral no AVE; 4) as manifestações clínicas e o diagnóstico por imagem; e 5) as recomendações atualizadas para as medidas de suporte, tratamento e profilaxia dos AVE em pediatria. Fontes dos dados:Realizou-se revisão da literatura nas bases de dados PubMed, EMBASE e SciELO utilizando-se como palavras-chave stroke, pediatrics e neonatology, além da utilização de referências bibliográficas importantes dos textos escolhidos. Síntese dos dados:A ocorrência de AVE em pediatria é incomum, com a incidência variando entre duas e oito por 100.000 crianças abaixo de 14 anos, tendo a maioria como denominador comum a ocorrência de doenças de base como cardiopatias congênitas, anemia falciforme e malformações vasculares. Não há padronização nas recomendações de tratamento para o AVE em crianças, embora as medidas fundamentais incluam monitoração, tratamento de suporte e anticoagulação em casos selecionados. O prognóstico depende da extensão de área cerebral acometida e da doença de base, mas as taxas de recorrência são altas na maioria dos casos. Conclusões:O diagnóstico precoce dos AVE em pediatria é fundamental, e é importante que os pediatras estejam atentos à falta de especificidade...

show abstract

“…29 Considering findings of cerebral ischemia on magnetic nuclear resonance studies (MR), lesions are found in up to 22% of infant patients. 30,31 Risk factors include previous transient ischemic events, 33,34 Major infarcts in the territory of the middle cerebral artery secondary to carotid lesions are also a common finding. Smaller lesions are also found involving the basal ganglia and white matter.…”

Section: Stroke and Cardiac Diseasesmentioning

confidence: 99%

Acidentes vasculares encefálicos em pediatria

Filho¹,

Carvalho²

2009

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

Objectives: To summarize 1) the definitions and epidemiological features of stroke in children; 2) the main risk factors that can lead to stroke in pediatrics and neonatology; 3) the main pathophysiological features involved in the genesis of brain injury in stroke; 4) the clinical manifestations and imaging diagnosis; and 5) the latest recommendations concerning the support measures, treatment, and prophylaxis of stroke in children.Sources: A review of the literature published in PubMed, EMBASE, and SciELO databases using the search terms stroke, pediatrics, and neonatology was performed, including relevant references from the chosen texts. Summary of the findings:Stroke in children are rare conditions, with incidence rates among two and eight per 100,000 children up to 14 years, and most cases show an underlying disease such as heart diseases, prothrombotic conditions, sickle-cell disease, and vascular malformations. There are no specific guidelines currently in place for the treatment of stroke in children, although central elements include support treatment, monitoring, and anticoagulation as secondary prevention in certain cases. Prognosis depends on the extent of brain damage and the underlying disease but recurrence rates are high in most cases. Conclusions:Early diagnosis of stroke in children is very important and pediatricians should be aware of the lack of specificity of the symptoms to avoid late sequelae and improve life quality.

show abstract

Acidente vascular cerebral e outras complicações do sistema nervoso central nas doenças falciformes

Cited by 19 publications

References 16 publications

Most prevalent clinical complications in patients with sickle cell disease from a mediumsized town in Minas Gerais, Brazil

Most prevalent clinical complications in patients with sickle cell disease from a mediumsized town in Minas Gerais, Brazil

Stroke in children

Acidentes vasculares encefálicos em pediatria

Contact Info

Product

Resources

About