Perfil sorológico para doença de Chagas dos doadores de sangue do Hemocentro Regional de Uberaba

Moraes-Souza, Hélio; Martins, Paulo Roberto Juliano; Pereira, Gilberto A.; Ferreira-Silva, Márcia Maria; Abud, Murilo Batista

doi:10.1590/s1516-84842006000200009

Cited by 20 publications

(28 citation statements)

References 5 publications

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“…Concerning the epidemiologic profile of those who were ineligible in relation to the total number of donors, the proportion of ineligible donors aged 30 years and above was significantly higher (which is in agreement with the literature, and expected given the vector-eliminating initiatives implemented in the endemic regions of the country) 12 ; individuals that were married and in other stable relationships also had increased ineligibility rates relative to single donors. The highest occurrence in married people and those in other stable relationships may be explained by their correlation with the higher age group in comparison to the single individuals.…”

Section: Discussionsupporting

confidence: 88%

“…The strong decreasing tendency for ineligibility due to Chagas disease infection (r = -0.89) during the 15 years of this study is likely due to factors such as systematic combat of the vector in the region since the 70s and the exhaustive work in the promoting customer loyalty of the blood donors at the HRU, which began more than 3 decades ago; today, more than 80% of blood donations are from return donors, the majority of which are fidelity donors 12 . Concerning the epidemiologic profile of those who were ineligible in relation to the total number of donors, the proportion of ineligible donors aged 30 years and above was significantly higher (which is in agreement with the literature, and expected given the vector-eliminating initiatives implemented in the endemic regions of the country) 12 ; individuals that were married and in other stable relationships also had increased ineligibility rates relative to single donors.…”

Section: Discussionmentioning

confidence: 82%

“…In Uberaba, the prevalence rate decreased from 16% in the 70s to 0.14% in 2006 12 . This latter study and the current study show that, despite the fact that Uberaba has already been a highly endemic area for Chagas disease, today it has one of the lowest national prevalence rates among blood donors.…”

Section: Discussionmentioning

confidence: 95%

“…According to Moraes-Souza, while the serological prevalence of Chagas disease in blood donors in Latin America and Brazil in the 70s, was 6.49% and 6.96% respectively, in 2006 it decreased to 1.28% and 0.21%. In Uberaba, the reduction in serum prevalence in this period was from 16.02% to 0.14% 3,12,13 .…”

Section: Introductionmentioning

confidence: 84%

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Prevalence of Chagas disease in blood donors at the Uberaba Regional Blood Center, Brazil, from 1995 to 2009

Lima

Alves

Barbosa³

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction: A retrospective study was conducted to assess the occurrence of blood donations that were ineligible due to Chagas disease infection� from 1995 to 2009 at the Uberaba Regional Blood Center (HRU), Brazil, verify the tendency of this ineligibility, and describe the epidemiologic profile of the donors. Methods: Retrospective studies of serological ineligibility due to Chagas disease, statistical analysis by means of the chi-square test and odds ratio, study of the tendencies using a dispersion graph and the linear correlation coefficient (r) were performed. Results: In the period under study, a 0.2% serum prevalence of ineligibility due to Chagas disease was found, with a significant drop in ineligible donations from 2001 to 2009. Among the serum positive-donors, there was a significant predominance among those aged 30 years or above and non-single individuals. Conclusions: The results show a rate of occurrence that is lower than that described in literature, as well as a progressive drop during the 15 years under assessment. Such results are a consequence of systematic combat of the vector since the 70s and the progressive and consistent increase of returning donors, resulting in a drop of the contamination risk factor by means of blood transfusion and in the improvement of the quality of hemotherapy practices in the HRU.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 84%

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Prevalence of Chagas disease in blood donors at the Uberaba Regional Blood Center, Brazil, from 1995 to 2009

Lima

Alves

Barbosa³

et al. 2012

Rev. Soc. Bras. Med. Trop.

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“…Como a maioria dos doadores de sangue está geralmente concentrada na faixa etária dos 18 aos 35 anos 8 , o menor número de candidatos chagásicos nos bancos de sangue, somado à obrigatoriedade da triagem sorológica, imposta na quase totalidade dos países endêmicos nos últimos anos, vem reduzindo a prevalência entre os doadores e, consequentemente, uma importante redução do risco da transmissão transfusional da doença de Chagas em toda a América Latina 3 (Tabela 1). Especificamente no Brasil, enquanto nos anos cinquenta a prevalência média de sorologia positiva para Trypanosoma cruzi era de 8,3%, nos anos sessenta e setenta caiu para 6,9% e, no final dos anos oitenta e início de noventa, para 3,2% 9 .…”

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O controle da transmissão transfusional

Moraes-Souza

Ferreira-Silva

2011

Rev. Soc. Bras. Med. Trop.

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A alta prevalência de doadores chagásicos nos bancos de sangue do Brasil (6,9%) e da América Latina (6,5%), nas décadas de 60 e 70, aliada ao combate ao vetor a partir dos anos setenta, fez com que a doença de Chagas transfusional, a partir da década de oitenta, se tornasse o principal mecanismo de transmissão da doença na maioria dos países endêmicos. Contudo, os resultados altamente favoráveis do combate ao vetor e da cobertura sorológica dos doadores, reduziu a prevalência de soropositividade para 0,2% e 1,3%, respectivamente, no Brasil e América Latina e o índice de transmissão anual, via transfusão de sangue no Brasil, de 20.000 para 13 em quatro décadas. Entretanto, paralelamente aos grandes avanços obtidos pelos países endêmicos, a doença de Chagas alcançou, via processo migratório, os países não endêmicos da América do Norte e da Europa, além do Japão e Austrália, colocando em risco os receptores de sangue destes países e transformando a doença de Chagas num problema de saúde global. A segurança transfusional, propiciada pela triagem sorológica, trouxe, porém outro importante problema, qual seja, a alta proporção de reações inconclusivas e dois grandes desafios: o significado de tais exames e que orientação proporcionar ao doador. Contudo, as estratégias adotadas pelos países não endêmicos e os avanços alcançados pelos endêmicos, prenunciam o breve, auspicioso e intensamente sonhado controle vetorial e transfusional da doença de Chagas. Palavras-chaves: Transfusão de sangue. Doença de Chagas. Transmissão transfusional. Medidas de controle. ABSTRACTThe high prevalence of chagasic blood donors in blood centers in Brazil (6.9%) and in Latin America (6.5%) in the 60's and 70's, together with the combat to the vector since the 70's have made transfusion Chagas disease the main mechanism of the disease transmission in the 80's. However, the highly favorable results achieved to eliminate the vector and the serologic screening of blood donors, reduced the prevalence of serum positivity to 0.2% and 1.3%, respectively and the rate of annual transmission through blood transfusion from 20.000 to 13 in four decades in Brazil. Nevertheless, despite outstanding advancements in endemic countries, Chagas disease reached, via migration, non-endemic countries in North America and Europe besides Japan and Australia, placing their blood recipients at risk and turning Chagas disease into a worldwide health problem. Transfusion safety through serologic selection raised another big issue i.e. high proportion of inconclusive reactions as well as two great challenges: the meaning of such exams and what guidelines to provide the donor. However, the strategies adopted by non-endemic countries and the advancements achieved by endemics so far forecast the highly wished vector and transfusion control of Chagas disease. O processo migratório no sentido campo-cidade, com o início da industrialização do Brasil, a partir da década de cinquenta, promoveu a urbanização da doença e foi responsável pela alta prevalência de doadores chagásicos...

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Chagas disease: Performance analysis of immunodiagnostic tests anti-Trypanosoma cruzi in blood donors with inconclusive screening results

Ferreira-Silva

Pereira

Rodrigues-Júnior

et al. 2021

Hematology, Transfusion and Cell Therapy

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Background The screening of Trypanosoma cruzi -infected blood donors using two serological techniques frequently leads to conflicting results. This fact prompted us to evaluate the diagnostic performance of four “in-house” immunodiagnostic tests and two commercially available enzyme-linked immunosorbent assays (ELISAs). Material and Methods One hundred and seventy-nine blood donors, whose screening for Chagas disease was doubtful, underwent three in-house ELISAs, one in-house immunoblotting test (TESA-blot), and two commercial ELISAs (bioMérieux and Wiener) in an attempt to define the presence or absence of infection. Simultaneously, 29 donors with previous positive results from three conventional serological tests and 30 donors with constant negative results were evaluated. Results The ELISA-Wiener showed the highest rate in sensitivity (98.92%) and the ELISA-bioMérieux, the highest specificity (99.45%), followed by the TESA-blot, which showed superior performance, with lower false-negative (2.18%) and false-positive (1.12%) rates. In series, the combination composed of the TESA-blot and ELISA-bioMérieux showed slightly superior performance, with trifunctional protein deficiency (TFP) = 0.01%. Conclusion Our study confirms the high sensitivity and specificity of commercial kits. To confirm the presence or absence of T. cruzi infection, the combination of TESA-blot and ELISA-bioMérieux may be suggested as the best alternative. Individually, the TESA-blot performed the closest to the gold standard; however, it is not commercially available.

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Perfil sorológico para doença de Chagas dos doadores de sangue do Hemocentro Regional de Uberaba

Cited by 20 publications

References 5 publications

Prevalence of Chagas disease in blood donors at the Uberaba Regional Blood Center, Brazil, from 1995 to 2009

Prevalence of Chagas disease in blood donors at the Uberaba Regional Blood Center, Brazil, from 1995 to 2009

O controle da transmissão transfusional

Chagas disease: Performance analysis of immunodiagnostic tests anti-Trypanosoma cruzi in blood donors with inconclusive screening results

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