Long-term follow-up of kidney allografts in patients with sickle cell hemoglobinopathy

Abstract

Although sickle cell anemia and sickle cell disease produce a variety of functional renal abnormalities they uncommonly cause end stage renal failure. Renal transplantation has been a successful alternative for the treatment of the rare terminal chronic renal failure with outcomes comparable with non-sickle recipients. This approach, however, has not been often described on patients with renal failure associated with SC hemoglobinopathy. Here we report the outcomes of two patients with chronic renal failure due to SC hemoglobinopathies who underwent renal transplantation. At the time of the transplantation they were both severely anemic and had frequent vasoocclosive pain crises. Both patients evolved with good allograft function, near normal hematological parameters, and very rare pain crisis, thirteen and eight years after transplant. These cases illustrate that terminal renal failure due to SC hemoglobinopathy can be successfully managed by renal transplantation and satisfactory longterm results are achievable not only in terms of renal allograft function but also of their hematological condition. Rev. bras. hematol. hemoter. 20003;25(2):111-114.

Toward dual hematopoietic stem-cell transplantation and solid-organ transplantation for sickle-cell disease

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