Resistant bacteria in stem cell transplant recipients

Nucci, Márcio

doi:10.1590/s1516-84842002000300009

Cited by 1 publication

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“…Between 1992 and 1997, quinolones were used in 43% of 420 episodes of fever and neutropenia, but in only one of 433 episodes between 1998 and 2001. The author reports that frequencies of Gram-negative and Gram-positive bacteremia were similar in the two periods, but the frequency of bacteremia due to quinolone-resistant E. coli was significantly higher (p=0.02) in the first period compared to the second period of observation (60% versus 6%, respectively) [38].…”

Section: Problems Of Resistance To Fluoroquinolones In Neutropenic Pamentioning

confidence: 96%

Fluoroquinolones Prophylaxis of Bacterial Infections in Neutropenic Patients: Time to Re-Evaluate

Cruciani

2007

CCTR

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Fluoroquinolones have been studied extensively as prophylaxis in neutropenic cancer patients. There is a large body of evidence suggesting that fluoroquinolones are a valuable choice for preventing bacterial infections in neutropenic cancer patient. As yet, there is no question that prophylaxis with fluoroquinolones has led to a decrease in the occurrence of gram-negative infections in neutropenic patients. By contrast, the benefits of fluoroquinolone prophylaxis on other parameters of infection-related morbidity and on the occurrence of infection-related mortality are not clear. Moreover, the use of fluoroquinolones is not without risk. Reports of fluoroquinolone-resistant Escherichia coli causing bacteremia among cancer patients are matter of concern. Recent well conducted, large clinical trials confirm the long lasting interest in the use of fluoroquinolones prophylaxis. Moreover, a reduction in mortality has been demonstrated in recent metaanalyses, though the generalizability of this finding is uncertain. Reports from cancer centers in Europe have shown a rebound of gram-negative bacteremias after discontinuation in the use of prophylaxis with fluoroquinolones. In light of the these findings, prophylaxis with a quinolone during granulocytopenia, where resistance permits, is still appropriate.

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Section: Problems Of Resistance To Fluoroquinolones In Neutropenic Pamentioning

confidence: 96%

Fluoroquinolones Prophylaxis of Bacterial Infections in Neutropenic Patients: Time to Re-Evaluate

Cruciani

2007

CCTR

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show abstract

Resistant bacteria in stem cell transplant recipients

Cited by 1 publication

References 33 publications

Fluoroquinolones Prophylaxis of Bacterial Infections in Neutropenic Patients: Time to Re-Evaluate

Fluoroquinolones Prophylaxis of Bacterial Infections in Neutropenic Patients: Time to Re-Evaluate

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