The history of the Diego blood group

Junqueira, P. C.; Castilho, Lilian

doi:10.1590/s1516-84842002000100004

Cited by 12 publications

(13 citation statements)

References 11 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Study showed that severe hemolytic anemia after childbirth was due to isoimmunization caused by an irregular antibody. This antibody along with the targeted previously unknown antigen were designated as the Diego system: Di a , and anti-Di a [ 7 ] using the woman’s married name. Since then, a total of 22 Diego antigens have been discovered dispersed at 16 antigenic sites on Band3.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Revisiting the Diego Blood Group System in Amerindians: Evidence for Gene-Culture Comigration

et al. 2015

View full text Add to dashboard Cite

Six decades ago the DI*A allele of the Diego blood group system was instrumental in proving Native American populations originated from Siberia. Since then, it has received scant attention. The present study was undertaken to reappraise distribution of the DI*A allele in 144 Native American populations based on current knowledge. Using analysis of variance tests, frequency distribution was studied according to geographical, environmental, and cultural parameters. Frequencies were highest in Amazonian populations. In contrast, DI*A was undetectable in subarctic, Fuegian, Panamanian, Chaco and Yanomama populations. Closer study revealed a correlation that this unequal distribution was correlated with language, suggesting that linguistic divergence was a driving force in the expansion of DI*A among Native Americans. The absence of DI*A in circumpolar Eskimo-Aleut and Na-Dene speakers was consistent with a late migratory event confined to North America. Distribution of DI*A in subtropical areas indicated that gene and culture exchanges were more intense within than between ecozones. Bolstering the utility of classical genetic markers in biological anthropology, the present study of the expansion of Diego blood group genetic polymorphism in Native Americans shows strong evidence of gene-culture comigration.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Di a antigen). Results showed that Di b antigen was ubiquitous but that Di a was exclusive to populations of Mongolian-descent from Poland to South America and totally absent in African, Aborigine and European populations [ 2 , 7 ]. Another noteworthy finding was the lack of Di a in some Native Americans.…”

Section: Introductionmentioning

confidence: 99%

Revisiting the Diego Blood Group System in Amerindians: Evidence for Gene-Culture Comigration

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Un dato relevante fue la presencia del 10% de antígeno Diego en la provincia de Manabí, en la que se identificó un 32% de aloinmunización por este antígeno, dato que muestra la necesidad de incluir pruebas de tipificación para el antígeno Diego en esta provincia. Otros estudios afirman que la frecuencia del antígeno Di a puede ser mayor en regiones de América del sur; en la población Kaingangues propia de la región de Santo Domingo, Cabo Verde, en Brasil, la prevalencia asciende hasta el 45.8% 11 . La identificación y localización de donantes de sangre portadores del antígeno Diego es de gran utilidad para los bancos de sangre debido a la relación existente entre este antígeno y la producción de anticuerpos causantes de reacciones hemolíticas postransfusionales.…”

Section: Resultsunclassified

“…Estos datos constituyen una información relevante por la probabilidad de aloinmunización en mujeres en edad fértil; a pesar de que existe una prevalencia alta, también existe un porcentaje de mujeres carentes del antíge-no, lo que podría ocasionar efectos adversos en una transfusión sanguínea incompatible e inclusive una EHRN. Layrisse, Arends y Domínguez fueron los investigadores que identificaron el primer caso de EHRN, determinando que los eritrocitos del niño se encontraban sensibilizados por anticuerpos anti-Di a provenientes de la madre 1,11 . Posteriormente se estableció que el antígeno Diego, que inicialmente fue considerado de baja prevalencia, se ha convertido en un «marcador de poblaciones mongoloides de gran valor genético y antropológico» 1 .…”

Section: Resultsunclassified

Frecuencia del antígeno y aloanticuerpos del sistema Diego en donantes de sangre

Góngora

Chiriboga-Ponce

2018

GMM

View full text Add to dashboard Cite

“…After conducting some blood tests intended to find a rare blood factor in the child and parents' blood, researchers found a new type classified as a "family" blood type and named it "Diego" after his father's surname. Initially considered to be rare, further investigations traced this group from the Venezuelan family to many other indigenous populations in Latin America and to the Mongolian race in Asia (Levine et al 1954; for a history of the Diego blood group see Junqueira and Castilho 2002). It is now known that the Diego system is composed of 22 blood factors or antigens carried on the band 3 glycoprotein also known as AE1 (Anion Exchanger 1) located in human chromosome 17.…”

Section: Boxmentioning

confidence: 99%

Medical Genetics and the First Studies of the Genetics of Populations in Mexico

Barahona

2016

Genetics

View full text Add to dashboard Cite

Following World War II (WWII), there was a new emphasis within genetics on studying the genetic composition of populations. This probably had a dual source in the growing strength of evolutionary biology and the new international interest in understanding the effects of radiation on human populations, following the atomic bombings in Japan. These global concerns were shared by Mexican physicians. Indeed, Mexico was one of the leading centers of this trend in human genetics. Three leading players in this story were Mario Salazar Mallén, Adolfo Karl, and Rubén Lisker. Their trajectories and the international networks in human genetics that were established after WWII, paved the way for the establishment of medical and population genetics in Mexico. Salazar Mallén's studies on the distribution and characterization of ABO blood groups in indigenous populations were the starting point while Karl's studies on the distribution of abnormal hemoglobin in Mexican indigenous populations showed the relationships observed in other laboratories at the time. It was Lisker's studies, however, that were instrumental in the development of population genetics in the context of national public policies for extending health care services to the Mexican population. In particular, he conducted studies on Mexican indigenous groups contributing to the knowledge of the biological diversity of human populations according to international trends that focused on the variability of human populations in terms of genetic frequencies. From the start, however, Lisker was as committed to the reconstruction of shared languages and practices as he was to building networks of collaboration in order to guarantee the necessary groundwork for establishing the study of the genetics of human populations in Mexico. This study also allows us to place Mexican science within a global context in which connected narratives describe the interplay between global trends and national contexts.

show abstract

The history of the Diego blood group

Cited by 12 publications

References 11 publications

Revisiting the Diego Blood Group System in Amerindians: Evidence for Gene-Culture Comigration

Revisiting the Diego Blood Group System in Amerindians: Evidence for Gene-Culture Comigration

Frecuencia del antígeno y aloanticuerpos del sistema Diego en donantes de sangre

Medical Genetics and the First Studies of the Genetics of Populations in Mexico

Contact Info

Product

Resources

About