The impact of organic and inorganic selenium on the immune system of growing broilers submitted to immune stimulation and heat stress

Abstract

One to 42-d-old (432) female broilers were fed different levels of inorganic selenium (ISe) and organic selenium (OSe), according to the following treatments: (1) 0.3 mg ISe; (2) 0.3 mg ISe + 0.2 mg OSe; (3) 0.5 mg ISe and (4) 0.3 mg OSe/ kg of feed. All birds were vaccinated against infectious bursal disease (IBD) at 19d of age and three birds/replicate (R) were inoculated with sheep red blood cells (SRBC) at 32d. Three other birds/R received Freund's adjuvant at 37d and avian tuberculin (AT) in the wattle at 47d of age. All birds were submitted to heat stress after 21d. Performance parameters, bursa and spleen weights, lymphocyte bursa depletion, antibody (Ab) production against IBD and SRBC, hematocrit, leukocytes, heterophil/lymphocyte ratio (H/L), and cellular reaction to AT were evaluated. The contrast analysis showed that OSe has improved feed intake (FI) between day 1 and 42 (p<0.10). Birds fed ISe presented worse H/L ratio (p<0.10), but higher Ab titers against IBD (p<0.04) and SRBC (p<0.05) than birds fed OSe, but OSe supplemented birds showed lower lymphocyte depletion scores in the bursa. The higher FI promoted by OSe may be beneficial when rearing broilers in hot weather. The use of ISe induced higher humoral immune respons

Organic trace minerals on productive performance, egg quality and immune response in Bovans White laying hens

“…In the present study, the absence of differences may be associated with hen age and constant immunization performed as part of the preventive management; it is also suggested that all treatments covered the needs of hens, and therefore, the effects of Tm were not evident. The CAFQ inclusion also had no effect on haematological parameters, which agrees with what was found by Attia et al, using manganese proteinates in hens age from 30 to 46 weeks and with Silva et al, who used broilers and yeasts as a selenium source. The H:L ratio is a parameter that has been used as a stress indicator; studies carried out with zinc methionine also did not report statistical differences when compared to ITM (Moghaddam & Jahanian, ).…”

“…Feng et al, observed some improvements after the use of zinc‐glycine chelates on IgA and IgY levels; similar results were obtained by Moghaddam & Jahanian, with zinc methionine on IgY titres and by Boostani et al, using selenium methionine on IgM. On the other hand, Silva et al, reported that the use of selenium methionine decreased the production of antibodies; they mentioned that the effect of this mineral is more related to tissues integrity and organs and metabolism improvement. Zinc deficiency in young animals has been reported to suppress antibody production due to poor development of the lymphoid tissue in the bursa of Fabricius (Burns, ).…”

“…Besides, positive effects have been observed on the bone mineralization (Gheisari et al, ; Manangi et al, ), Tm levels in serum (Yenice et al, ), retention in organs (Jlali et al, ; Sun et al, ) and in the activity of some enzymes (Sun et al, ). In respect of immune response, the inclusion of organic Se and Zn has been shown to improve the enzymatic activity against free radicals (Boostani, Sadeghi, Mousavi, Chamani, & Kashan, ; Saad, Gertner, Bona, & Santin, ), the antibody titres (Feng et al, ; Manangi et al, ; Silva et al, ), the size of lymphoid organs (Feng et al, ) and the cellular immune response (Moghaddam & Jahanian, ).…”

Effects of organic, inorganic, and nano-Se on growth performance, antioxidant capacity, cellular and humoral immune responses in broiler chickens exposed to oxidative stress

“…In this study, IgM and IgG concentrations in response to SRBC in groups with nano-Se and organic Se in nonoxidative condition and nano-Se and organic Se increased anti-SRBC antibody. In contrast, Da Silva et al (2010) concluded that usage of organic Se decreased antibody titers against SRBC. The action of this source of Se may be more related to tissue and organ integrity, and to the enhancement of metabolic systems that are key to the organic balance.…”

Immunomodulatory and prophylactic efficacy of herbal extracts against experimentally induced chicken infectious anaemia in chicks: assessing the viral load and cell mediated immunity

“…Vitamin E provides the first line of defense against oxidative damage, increases lymphoproliferative responses, phagocytic functions and T cell hyper activity [21] and these may be mediated by enhancing the antioxidant activity in the lymphoid tissues [22]. Selenium is an essential nutrient for poultry, which stimulates phagocytosis and chemotaxis of macrophages and neutrophils.…”