Use of anticholinergic drugs and worsening of pemphigus foliaceus in a patient with bipolar disorder

Botelho-Nogueira, Lúcio; Miranda‐Scippa, Ângela

doi:10.1590/s1516-44462011000400017

Cited by 4 publications

(5 citation statements)

References 4 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is worth noting that both mAChR and nAChR are expressed on the keratinocyte membrane, and regulate cell adhesion synergistically. Either nicotinic or muscarinic antagonists cause acantholysis in keratinocyte monolayers and worsening of pemphigus . Thus, it is not surprising to find a correlation of anti‐mAChR antibody levels and the extent of disease in pemphigus, even though these patients could hardly be diagnosed as having MG in the absence of any myasthenic symptom .…”

Section: Discussionmentioning

confidence: 99%

“…Either nicotinic or muscarinic antagonists cause acantholysis in keratinocyte monolayers and worsening of pemphigus. [40][41][42][43][44] Thus, it is not surprising to find a correlation of anti-mAChR antibody levels and the extent of disease in pemphigus, even though these patients could hardly be diagnosed as having MG in the absence of any myasthenic symptom. 45 The reported antibody subtypes found in pemphigus are against a3, a9, a10 and e nAChR, and M1, M2, M4 and M5 mAChR, although the positive proportions of these anti-AChR antibody subtypes were small.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of myasthenia gravis and associated autoantibodies in paraneoplastic pemphigus and their correlations with symptoms and prognosis

Wang

et al. 2015

Br J Dermatol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of myasthenia gravis and associated autoantibodies in paraneoplastic pemphigus and their correlations with symptoms and prognosis

Wang

et al. 2015

Br J Dermatol

View full text Add to dashboard Cite

show abstract

“…Our early reports that PV and PF patients develop antibodies to keratinocyte AChRs [28], [64] and that cholinomimetic drugs can ameliorate pemphigus [65] have been recently corroborated by new clinical and laboratory data. AChR antibodies in PV patients correlate with disease extent at the time of diagnosis and during follow-up [66], and, in a patient with bipolar disorder, cholinolytic drugs worsen PF [67].…”

Section: Discussionmentioning

confidence: 99%

Pemphigus Vulgaris Autoantibody Profiling by Proteomic Technique

et al. 2013

View full text Add to dashboard Cite

Pemphigus vulgaris (PV) is a mucocutaneous blistering disease characterized by IgG autoantibodies against the stratified squamous epithelium. Current understanding of PV pathophysiology does not explain the mechanism of acantholysis in patients lacking desmoglein antibodies, which justifies a search for novel targets of pemphigus autoimmunity. We tested 264 pemphigus and 138 normal control sera on the multiplexed protein array platform containing 701 human genes encompassing many known keratinocyte cell-surface molecules and members of protein families targeted by organ-non-specific PV antibodies. The top 10 antigens recognized by the majority of test patients’ sera were proteins encoded by the DSC1, DSC3, ATP2C1, PKP3, CHRM3, COL21A1, ANXA8L1, CD88 and CHRNE genes. The most common combinations of target antigens included at least one of the adhesion molecules DSC1, DSC3 or PKP3 and/or the acetylcholine receptor CHRM3 or CHRNE with or without the MHC class II antigen DRA. To identify the PV antibodies most specific to the disease process, we sorted the data based on the ratio of patient to control frequencies of antigen recognition. The frequency of antigen recognition by patients that exceeded that of control by 10 and more times were the molecules encoded by the CD33, GP1BA, CHRND, SLC36A4, CD1B, CD32, CDH8, CDH9, PMP22 and HLA-E genes as well as mitochondrial proteins encoded by the NDUFS1, CYB5B, SOD2, PDHA1 and FH genes. The highest specificity to PV showed combinations of autoantibodies to the calcium pump encoded by ATP2C1 with C5a receptor plus DSC1 or DSC3 or HLA-DRA. The results identified new targets of pemphigus autoimmunity. Novel autoantibody signatures may help explain individual variations in disease severity and treatment response, and serve as sensitive and specific biomarkers for new diagnostic assays in PV patients.

show abstract

“…Alterations of cholinergic system in KCs can produce acantholysis (reviewed in [12]), and pharmacological blockade of ACh receptors can worsen pemphigus [13].…”

Section: Introductionmentioning

confidence: 99%

Pemphigus vulgaris antibodies target the mitochondrial nicotinic acetylcholine receptors that protect keratinocytes from apoptolysis

Chernyavsky

Chen

Grando

2015

International Immunopharmacology

View full text Add to dashboard Cite

Use of anticholinergic drugs and worsening of pemphigus foliaceus in a patient with bipolar disorder

Cited by 4 publications

References 4 publications

Prevalence of myasthenia gravis and associated autoantibodies in paraneoplastic pemphigus and their correlations with symptoms and prognosis

Prevalence of myasthenia gravis and associated autoantibodies in paraneoplastic pemphigus and their correlations with symptoms and prognosis

Pemphigus Vulgaris Autoantibody Profiling by Proteomic Technique

Pemphigus vulgaris antibodies target the mitochondrial nicotinic acetylcholine receptors that protect keratinocytes from apoptolysis

Contact Info

Product

Resources

About