Long-term mood disorder antedating the diagnosis of Wilson's disease

Introduction:Wilson’s disease is an inherited disorder caused by a gene located on chromosome 13, which involved copper transportation across cell membranes. The disease can cause a reduced incorporation of copper into ceruloplasmin resulting in accumulation of this metal in the liver, central nervous system, kidneys and other organs. The objective is to define the frequencies of psychiatric disorders in WD, the amount of impairment of Quality of Life [QoL] in patients with WD and the relevance of the psychiatric disorders in the QoL of people suffering by WD.Methods:This is a systematic review. The search of the significant articles was carried out in PubMed using specific key words.Results:Such other neurological diseases, WD is characterized by chronic course and need of treatments, impairment of functional outcomes and high frequency of psychiatric symptoms, although a specific association between Bipolar Disorders and WD was recently found. Despite this, since today few studies are carried on WD patients’ quality of life related to psychiatric symptoms. Some new reports showed a link between presence of Bipolar Disorders diagnosis, cerebral damage and low Qol.Conclusion:Prospective studies on large cohorts are required to establish the effective impact of psychiatric disorders comorbidity, particularly Bipolar Disorders, on quality of life in WD and to clarify the causal link between brain damage, psychiatric disorders and worsening of QoL.

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“…There are few case-reports in the literature of typical Bipolar Disorder as presenting symptom of WD [47, 57-61]. …”

Section: Resultsmentioning

confidence: 99%

Quality of Life and Psychiatric Symptoms in Wilson’s Disease: the Relevance of Bipolar Disorders

Carta

Mura²,

Sorbello³

et al. 2012

CPEMH

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“…WD presentation with psychotic manifestation also encompassed the rare syndrome of catatonia in youth (Nayak et al, 2012;Sahoo, Avasthi, Sahoo, Modi, & Biswas, 2010) and even in paediatric age (Davis & Borde, 1993). Despite the interest on the association between WD and schizophrenia-like disorders, the occurrence of WD with bipolar disorder (BD) spectrum symptoms at its onset (with manic/hypomanic episodes, over-activity, irritability, aggressive behaviour, disinhibition, suicide attempts) has been most frequently described in case reports (Aravind, Krishnaram, Neethiarau, & Srinivasan, 2009;Chand & Murthy, 2006;Keller, Torta, Lagget, Crasto, & Bergamasco, 1999;Machado et al, 2008;McDonnell & Esmonde, 1999;M€ uller, 1999;Nazariah, Aisah, Anita, Yeoh, & Ng, 2011;Vale, Caramelli, & Teixeira, 2011). As shown below, this association was further confirmed by epidemiological studies on the course of WD.…”

Section: Wd Presenting As a Psychiatric Disordermentioning

confidence: 99%

Psychiatric comorbidity in Wilson’s disease

Mura

Zimbrean

Demelia

et al. 2017

International Review of Psychiatry

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Wilson's disease (WD) is a relatively rare autosomal recessive inherited disorder causing copper accumulation in different organs, mainly the liver and brain. Psychiatric disturbances represent a diagnostic and therapeutic issue in WD. A search for relevant articles was carried out on PubMed/Medline, Scopus, and Google Scholar, for papers focused on psychiatric disorders in WD published between 1985-2016. Ninety-two articles were included in this review, showing the findings from 35 observational and case-control studies and 57 case reports. This study discussed the findings on the prevalence of psychiatric symptoms in WD, their impact on the life of those diagnosed, and the efficacy of available treatments on the psychiatric outcomes of WD. Psychiatric disorders are confirmed frequent in WD, with a high prevalence of mood disorders, and contribute to worse Quality-of-Life and psychosocial outcomes. Because specific therapies for WD lead to a good life expectancy, adherence to medicaments and clinical monitoring should be warranted by a multidisciplinary approach, including a hepathologic, neurologic, and psychiatric careful evaluation and education of those affected and their relatives.

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