Bipolar disorder and multiple sclerosis: comorbidity and risk factors

Cerqueira, Ana Cláudia Rodrigues de; Nardi, Antônio Egídio; Souza-Lima, Fabiana; Godoy-Barreiros, José Maurício

doi:10.1590/s1516-44462010000400021

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…Bipolar disorder has been associated with many autoimmune disorders and few studies have indicated the coexistence of multiple sclerosis [ 25 , 26 , 27 ]. The involvement of the human leukocyte antigen (HLA) gene complex has been postulated as one of the possible explanations for this increased susceptibility [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Gender Differences and Comorbidities in U.S. Adults with Bipolar Disorder

et al. 2018

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Background: Past studies have evaluated the association of various comorbidities with bipolar disorder. This study analyzes differences in the prevalence and association of medical and psychiatric comorbidities in bipolar patients by gender. Methods: A retrospective analysis was conducted using the Nationwide Inpatient Sample (2010–2014). Using International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes, we narrowed the study population to comprise those with a primary diagnosis of bipolar disorder and then obtained information about comorbidities. The differences in comorbidities by gender were quantified using chi-square tests and the logistic regression model (odds ratio (OR)). Results: Hypertension (20.5%), asthma (12.5%) and hypothyroidism (8.1%) were the top medical comorbidities found in bipolar patients. Migraine and hypothyroidism were seen three times higher in females (OR = 3.074 and OR = 3.001; respectively). Females with bipolar disorder had higher odds of comorbid inflammatory disorders like asthma (OR = 1.755), Crohn’s disease (OR = 1.197) and multiple sclerosis (OR = 2.440) compared to males. Females had a two-fold higher likelihood of comorbid post-traumatic stress disorder (PTSD) (OR = 2.253) followed by personality disorders (OR = 1.692) and anxiety disorders (OR = 1.663) compared to males. Conclusion: Women with bipolar disorder have a much higher medical comorbidity burden than men and may highly benefit from an integrated team of physicians to manage their condition and improve their health-related quality of life.

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Section: Discussionmentioning

confidence: 99%

Gender Differences and Comorbidities in U.S. Adults with Bipolar Disorder

et al. 2018

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“…Hence, an early diagnosis and treatment of these psychiatric symptoms could play an important role in the prognosis and quality of life in MS patients, considering that psychiatric symptoms are more common than other neurological disorders (10,11). However, few studies have evaluated the personality and temperament dimensions or the co-occurrence of BDs with MS (12,13,14,15,16).…”

Section: Introductionmentioning

confidence: 99%

Affective Temperament Profiles in Patients with Multiple Sclerosis: Association with Mood Disorders

Özkan¹,

Altınbaş²,

Koç³

et al. 2016

Arch Neuropsychiatr

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Our results suggest that higher scores for affective temperament in MS patients indicate subclinical manifestations of mood disorders. Higher hyperthymia scores and manic symptoms detected in the RRMS group could shed light on the relationship between bipolarity and MS. Thus, the screening of bipolarity and affective temperament profiles in MS patients could help clinicians predict future mood episodes and decrease their impact on disease severity.

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“…Bipolar disorder and MS coexistence is not common but well proven. A few cases have been already reported [5–8]. The link between these two disorders is not fully determined.…”

Section: Introductionmentioning

confidence: 99%

Bipolar Disorder and Multiple Sclerosis: A Case Series

Sidhom

Djebara

Hizem

et al. 2014

Behavioural Neurology

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Background. The prevalence of psychiatric disturbance for patients with multiple sclerosis (MS) is higher than that observed in other chronic health conditions. We report three cases of MS and bipolar disorder and we discuss the possible etiological hypothesis and treatment options. Observations. All patients fulfilled the McDonald criteria for MS. Two patients were followed up in psychiatry for manic or depressive symptoms before developing MS. A third patient was diagnosed with MS and developed deferred psychotic symptoms. Some clinical and radiological features are highlighted in our patients: one manic episode induced by high dose corticosteroids and one case of a new orbitofrontal MRI lesion concomitant with the emergence of psychiatric symptoms. All patients needed antipsychotic treatment with almost good tolerance for high dose corticosteroids and interferon beta treatment. Conclusions. MRI lesions suggest the possible implication of local MS-related brain damage in development of pure “psychiatric fits” in MS. Genetic susceptibility is another hypothesis for this association. We have noticed that interferon beta treatments were well tolerated while high dose corticosteroids may induce manic fits.

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Bipolar disorder and multiple sclerosis: comorbidity and risk factors

Cited by 6 publications

References 5 publications

Gender Differences and Comorbidities in U.S. Adults with Bipolar Disorder

Gender Differences and Comorbidities in U.S. Adults with Bipolar Disorder

Affective Temperament Profiles in Patients with Multiple Sclerosis: Association with Mood Disorders

Bipolar Disorder and Multiple Sclerosis: A Case Series

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