Should we redefine the concept of endophenotype in schizophrenia?

Pantelis, Christos; Wood, Stephen; Velakoulis, Dennis; Testa, Renée; Fontenelle, Leonardo F.; Yücel, Murat

doi:10.1590/s1516-44462010000200003

Cited by 8 publications

(4 citation statements)

References 10 publications

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“…As noted above, tile criteria for endophenotypes have evolved slightly, and the concept has been clarified in tile past decade. Clinical evidence in schizophrenia and other disorders that become manifest during development, for example, challenged the criterion of state independence as mandatory and suggested allowing changes during active stages of brain maturation in adolescence and early adultllood (Pantelis et al 2010). Iacono & Malone (2011) cited a variety of sets of criteria, provided a particularly detailed set, and emphasized that developmental considerations have received too little attention in prior literature.…”

Section: Defining the Endophenotypementioning

confidence: 99%

Endophenotypes in Psychopathology Research: Where Do We Stand?

Miller

Rockstroh

2013

Annu. Rev. Clin. Psychol.

134

130

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Endophenotypes for psychopathology have been conceived as latent, unobserved, but measureable manifestations of phenomena that causally connect genetic liability to clinical disorder. Several decades of research have led to refinement of the construct and identification of some candidate endophenotypes, but rather limited progress on finding the genes involved or the mechanisms by which endophenotypes are driven by genetic and environmental factors and in turn drive psychopathology. Currently promising avenues for research involve development of transdiagnostic concepts not limited to traditional diagnostic categories, measures of endophenotypic and manifest psychopathology that have higher validity than those categories, and methods for modeling complex relationships among diverse contributors to etiology. With more grounding in animal neuroscience and other aspects of basic biological and psychological science, exemplified in the Research Domain Criteria initiative, there is every reason to anticipate that the endophenotype concept will grow more central in the psychopathology literature.

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Section: Defining the Endophenotypementioning

confidence: 99%

Endophenotypes in Psychopathology Research: Where Do We Stand?

Miller

Rockstroh

2013

Annu. Rev. Clin. Psychol.

134

130

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show abstract

“…Thus, when considered in this way, deficits in certain executive functions can be interpreted in the context of a disruption, or neurodevelopmental arrest, of the maturational trajectory of such ability [10,50]. For example, this is particularly apparent for spatial working memory ability, which is impaired from before illness onset [51].…”

Section: Evidence For Cognitive Decline In Early Psychosismentioning

confidence: 99%

Cognitive intervention in early psychosis — preserving abilities versus remediating deficits

Pantelis

Wannan

Bartholomeusz

et al. 2015

Current Opinion in Behavioral Sciences

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“…Developmental changes in GMV occur at different rates in different brain regions (Sowell et al, 2003; Gogtay et al, 2004). Pantelis et al (2010) focused on progressive changes in GM in the PFC, insula, and STG throughout the transition to psychosis in longitudinal studies of patients with UHR, as opposed to inconsistent findings from cross-sectional comparisons in the same cohorts. Trajectories of brain development may be more informative than cross-sectional studies of structural abnormalities.…”

Section: Potential Issues and Future Directionsmentioning

confidence: 99%

“…Many researchers have suggested the heritability of dynamic brain changes in normal individuals and non-affected relatives (Gogtay et al, 2007; Raznahan et al, 2011). If abnormalities in normal development are potential endophenotypes, the concept of the endophenotype in schizophrenia should be redefined (Pantelis et al, 2010). Future studies should clarify the theory that genes associated with brain development during adolescence and early adulthood affect brain abnormalities by accelerating the process of normal neurodevelopment.…”

Section: Potential Issues and Future Directionsmentioning

confidence: 99%

Gray Matter Volumetric Abnormalities Associated with the Onset of Psychosis

Jung¹,

Borgwardt²,

Fusar‐Poli³

et al. 2012

Front. Psychiatry

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Patients with psychosis display structural brain abnormalities in multiple brain regions. The disorder is characterized by a putative prodromal period called ultra-high-risk (UHR) status, which precedes the onset of full-blown psychotic symptoms. Recent studies on psychosis have focused on this period. Neuroimaging studies of UHR individuals for psychosis have revealed that the structural brain changes observed during the established phases of the disorder are already evident prior to the onset of the illness. Moreover, certain brain regions show extremely dynamic changes during the transition to psychosis. These neurobiological features may be used as prognostic and predictive biomarkers for psychosis. With advances in neuroimaging techniques, neuroimaging studies focusing on gray matter abnormalities provide new insights into the pathophysiology of psychosis, as well as new treatment strategies. Some of these novel approaches involve antioxidants administration, because it is suggested that this treatment may delay the progression of UHR to a full-blown psychosis and prevent progressive structural changes. The present review includes an update on the most recent developments in early intervention strategies for psychosis and potential therapeutic treatments for schizophrenia. First, we provide the basic knowledge of the brain regions associated with structural abnormalities in individuals at UHR. Next, we discuss the feasibility on the use of magnetic resonance imaging (MRI)-biomarkers in clinical practice. Then, we describe potential etiopathological mechanisms underlying structural brain abnormalities in prodromal psychosis. Finally, we discuss the potentials and limitations related to neuroimaging studies in individuals at UHR.

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Should we redefine the concept of endophenotype in schizophrenia?

Cited by 8 publications

References 10 publications

Endophenotypes in Psychopathology Research: Where Do We Stand?

Endophenotypes in Psychopathology Research: Where Do We Stand?

Cognitive intervention in early psychosis — preserving abilities versus remediating deficits

Gray Matter Volumetric Abnormalities Associated with the Onset of Psychosis

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