Bipolar disorder first episode and suicidal behavior: are there differences according to type of suicide attempt?

Neves, Fernando Silva; Malloy-Diniz, Leandro Fernandes; Barbosa, Izabela Guimarães; Brasil, Paulo Marcos; Corrêa, Humberto

doi:10.1590/s1516-44462009000200006

Cited by 24 publications

(15 citation statements)

References 33 publications

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“…More frequent suicide attempts in patients who had depressive first episode seems to be a part of the process. This is consistent with previous studies (28)(29)(30). Since patients with depressive first episode less commonly seek treatment and rate of having bipolar disorder diagnosis is lower in this group, possible risk of suicide attempt is overlooked, as well (31).…”

Section: Discussionsupporting

confidence: 91%

Bipolar Bozukluk Ve Özkıyım / Bipolar Disorder and Suicide

Eroğlu¹,

Karakuş²,

Tamam³

2013

Dusunen Adam

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Bipolar disorder and suicideObjective: The risk factors associated with suicidal behaviour in bipolar patients are not clear yet. We aimed to evaluate the frequency of suicide attempt, type of suicide attempt and significant clinical characteristics associated with suicide attempts.Methods: One hundred twenty two consecutive patients, from Bipolar Disorder Unit of Çukurova University, Faculty of Medicine, Department of Psychiatry, are included in this study. "Affective Disorders Patient Registry Form" was developed by Bipolar Disorder Unit and SCID-I were used in this study to collect the data. These forms are filled in through interviews with patients and their relatives, and evaluation of inpatient files.Results: The prevalence of suicide attempt was 19.7% in the outpatient group. Lifetime history of suicidal behavior was significantly associated with following characteristics: being a woman, depression as a first episode and indicators of severity of bipolar disorder including duration of illness, duration of untreated illness (latency), number of hospitalization, number of total mood episodes, number of depressive episodes, number of mixed episodes, positive familial psychiatric disorder history.Conclusion: Our study showed that patients with bipolar disorder have a high rate of suicide attempt. Reduction of the duration of untreated illness, prevention of mood episodes, assessment of suicide risk during depressive and mixed episodes should be the main targets of the treatment. Detection of warning signs about suicide among patients with bipolar disorder may help to distinguish the risky group and prevent suicide. ÖZET Bipolar bozukluk ve özkıyımAmaç: Bipolar bozukluk hastalarında özkıyım girişimiyle ilgili risk faktörleri halen tam olarak bilinmemektedir. Çalışmamız, bu hastalarda özkıyım girişiminin sıklığı, özkıyım şekilleri ve özkıyımla ilişkili klinik özellikleri değerlendirmeyi amaçlamaktadır. Yöntem: Çukurova Üniversitesi Tıp Fakültesi Ruh Sağlığı ve Hastalıkları Anabilim Dalı Bipolar Bozukluk Birimi'ne ayaktan başvuran 122 hasta çalışmaya alınmıştır. Duygudurum Bozukluğu Hasta Kayıt ve İzleme Formu ve DSM-IV Eksen I bozuklukları için Yapılandırılmış Klinik Görüşme Ölçeği (SCID-I) kullanılmıştır. Ölçekler, hastalarla ve hasta yakınlarıyla yapılan görüşmeler ve takip dosyaları ışığında doldurulmuştur.Bulgular: Ayaktan izlenen bipolar bozukluk hastalarında özkıyım girişimi sıklığı %19.7 olarak saptanmıştır. Çalışmamız, özkıyım girişimiyle kadın cinsiyet, hastalığın ciddiyetini gösteren hastalık süresi, tedavisiz hastalık süresi (latans), hastaneye yatış sayısı, geçirilmiş toplam dönem sayısı, depresif dönem sayısı, karma dönem sayısı ve ailede psikiyatrik hastalık öyküsünün olması gibi klinik özellikler arasında anlamlı bir ilişki olduğunu göstermiştir.Sonuç: Çalışmamız, bipolar bozukluk hastalarında özkıyım girişimi sıklığının yüksek olduğunu göstermiştir. Tedavisiz hastalık süresinin azaltılması, duygudurum dönemlerinin önlenmesi, depresif ve karma dönemler sırasında özkıyım riskinin değerlendirilmesi ...

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Section: Discussionsupporting

confidence: 91%

Bipolar Bozukluk Ve Özkıyım / Bipolar Disorder and Suicide

Eroğlu¹,

Karakuş²,

Tamam³

2013

Dusunen Adam

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“…1,2 We report the case of a 39-year-old, righthanded man with severe treatment-refractory OCD and bipolar disorder type I (BD-I), beginning at age 17 (without any other psychiatric disorder), who developed late-onset PA after DBS implant placement.…”

Section: Disclosurementioning

confidence: 99%

“…Analyses of correlation between peritumoral edema and coexistence of psychiatric symptoms have indicated that the underlying pathophysiological mechanism is likely related to disruptions in intracerebral pathways rather than with a mass effect of meningioma on intracranial pressure. 2 Indeed, headache, papilledema, and focal neurological signs often arise only when the meningioma has reached an advanced stage. Often, the correct diagnosis is established only after intracranial hypertension has caused irreversible cerebral damage.…”

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confidence: 99%

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Sexual abuse and suicide attempt in bipolar type I patients

Duarte

Neves

Albuquerque

et al. 2015

Rev. Bras. Psiquiatr.

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“…An increased likelihood of a suicide attempt has been described in persons who have experienced adverse life events [22] and use tobacco [8]. Among bipolar patients, additional risk factors for suicide attempts are the presence of rapid-cycling and mixed states [23] and depressive episodes at onset [24]; on the contrary, preponderance of manic episodes appears to be a risk-reducing factor [25]. A previous history of suicide attempt is the most reliable single predictor of future suicidal behavior (both attempted and completed suicide) in patients affected by mood disorders [20,[26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Clinical and genetic factors associated with suicide in mood disorder patients

Antypa¹,

Souery²,

Tomasini³

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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stronger predictor of current suicide risk. No associations were found with polymorphisms within COMT and BDNF genes, whereas significant associations were found with variations in rs13515 (MAPK1) and rs6740584 (CREB1) polymorphisms. From a clinical perspective, our study proposes several clinical characteristics, such as increased depressive symptomatology, anxiety comorbidity, functional disability and family history of suicidality, as correlates associated with suicide. Genetic risk variants in MAPK1 and CREB1 genes might be involved in a dysregulation of inflammatory and neuroplasticity pathways and are worthy of future investigation.

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Bipolar disorder first episode and suicidal behavior: are there differences according to type of suicide attempt?

Cited by 24 publications

References 33 publications

Bipolar Bozukluk Ve Özkıyım / Bipolar Disorder and Suicide

Bipolar Bozukluk Ve Özkıyım / Bipolar Disorder and Suicide

Sexual abuse and suicide attempt in bipolar type I patients

Clinical and genetic factors associated with suicide in mood disorder patients

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