Cognitive impairment in a Brazilian sample of patients with bipolar disorder

Schneider, Júlia Jochims; Candiago, Rafael Henriques; Rosa, Adriane Ribeiro; Ceresér, Keila Maria Mendes; Kapczinski, Flávio

doi:10.1590/s1516-44462008000300006

Cited by 11 publications

(9 citation statements)

References 39 publications

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“…11,12 Sustained attention, verbal learning and memory are particularly impaired in bipolar patients. 13,14 Martínez-Arán et al examined cognitive functions across all phases of bipolar disorder (manic/hypomanic, depressed, euthymic) and found impaired performance in verbal memory and prefrontal executive tasks in all phases of the disorder as compared to healthy subjects. 9 The impairment in cognitive function has been pointed out as a possible endophenotypic marker in genetic studies of bipolar disorder.…”

Section: Introductionmentioning

confidence: 99%

Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder

Tramontina

Yates

Magalhães

et al. 2009

Rev. Bras. Psiquiatr.

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OBJECTIVE: In the present study, we investigate the association between the val66met polymorphism of the brain-derived neurotrophic factor (BNDF) and the performance on the Wisconsin Card Sorting Test in a sample of Caucasian Brazilian patients with bipolar disorder. METHOD: Sixty-four patients with bipolar disorder were assessed and their performance on the Wisconsin Card Sorting Test was compared with the allele frequency and genotype of the val66met polymorphism of the brain-derived neurotrophic factor. RESULTS: The percentage of non-perseverative errors was significantly higher among patients with the val/val genotype. There was no association between (BNDF) genotype frequency and other Wisconsin Card Sorting Test domains. CONCLUSION: Our results did not replicate previous descriptions of an association between a worse cognitive performance and the presence of the met allele of the val66met brain-derived neurotrophic factor gene polymorphism.

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Section: Introductionmentioning

confidence: 99%

Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder

Tramontina

Yates

Magalhães

et al. 2009

Rev. Bras. Psiquiatr.

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“…Yazında, hastalık süresi uzadıkça yürütücü işlevler, görsel mekansal bellek ve sözel bellekte bozulmanın arttığı bildirilmiştir. En tutarlı ortak bulgu sözel bellekteki bozulmalarla ilişkilidir (1,11,40,41,(45)(46)(47) .…”

Section: Discussionunclassified

“…Takip çalışmaları, bu hastaların yaşamlarında hastalık dönemlerinin iyilik dö-nemlerinden daha fazla süre kapsadığını, bu durumun psikososyal ya da mesleki işlevsellikle-rinin azalmasına neden olduğunu bildirmektedir (1).…”

Section: Introductionunclassified

İki̇ Uçlu Duygudurum Bozukluğu Tanili Hastalarin Depresyon, Eşi̇kalti Depresyon Ve İyi̇li̇k Dönemleri̇ni̇n Nöropsi̇koloji̇k Açidan Karşilaştirilmasi

Temur¹,

Güleç²,

Akarsu³

et al. 2016

Osmangazi̇ Journal of Medicine

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“…4 Bipolar patients also experience functional impairment in various forms, low levels of quality of life, and the possibility of being stigmatized. 5 Part of these losses are also due to high rates of comorbidity with psychiatric axis I and II disorders, with therapeutic and prognostic implications. 6,7 Among the comorbidities of greater impact in patients with BD are personality disorders (PDs).…”

Section: Introductionmentioning

confidence: 99%

Personality disorders in euthymic bipolar patients: a systematic review

Bezerra-Filho

Almeida

Studart

et al. 2015

Rev. Bras. Psiquiatr.

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Objective: To identify, by means of a systematic review, the frequency with which comorbid personality disorders (PDs) have been assessed in studies of euthymic bipolar patients. Methods: PubMed, SciELO and PsychINFO databases were searched for eligible articles published between 1997 and 2013. After screening 1,249 empirical papers, two independent reviewers identified three articles evaluating the frequency of PDs in patients with bipolar disorders assessed in a state of euthymia.Results: The total sample comprised 376 euthymic bipolar patients, of whom 155 (41.2%) had at least one comorbid PD. Among them, we found 87 (23.1%) in cluster B, 55 (14.6%) in cluster C, and 25 (6.6%) in cluster A. The frequencies of PD subtypes were: borderline, 38 (10.1%); histrionic, 29 (7.7%); obsessive-compulsive, 28 (7.4%); dependent, 19 (5%); narcissistic, 17 (4.5%); schizoid, schizotypal, and avoidant, 11 patients each (2.95%); paranoid, five (1.3%); and antisocial, three (0.79%). Conclusion: The frequency of comorbid PD was high across the spectrum of euthymic bipolar patients. In this population, the most common PDs were those in cluster B, and the most frequent PD subtype was borderline, followed by histrionic and obsessive-compulsive.

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Cognitive impairment in a Brazilian sample of patients with bipolar disorder

Cited by 11 publications

References 39 publications

Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder

Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder

İki̇ Uçlu Duygudurum Bozukluğu Tanili Hastalarin Depresyon, Eşi̇kalti Depresyon Ve İyi̇li̇k Dönemleri̇ni̇n Nöropsi̇koloji̇k Açidan Karşilaştirilmasi

Personality disorders in euthymic bipolar patients: a systematic review

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