Aripiprazole worsening positive symptoms and memantine reducing negative symptoms in a patient with paranoid schizophrenia

Increased Anxiety, Akathisia, and Suicidal Thoughts in Patients with Mood Disorder on Aripiprazole and Lamotrigine

“…There have been three case reports of suicidal ideation and suicide attempts after patients began using aripiprazole [ 16 – 18 ]. There have also been reports of worsening positive symptoms and disinhibition [ 19 ]. With respect to anxiety, we were unable to find any reference to aripiprazole worsening or provoking symptoms of anxiety.…”

Aripiprazole for late-life schizophrenia

“…Two weeks after switching to aripiprazole, his EPS symptoms resolved and auditory hallucinations dissipated. By contrast, a 72-year-old woman with schizophrenia experienced worsening of her positive symptoms after switching to aripiprazole 35. Previously treated with haloperidol, this patient was initiated on aripiprazole (7.5 mg daily) and titrated up to 15 mg daily.…”

Off-label Use of Memantine as Adjunctive Treatment in Schizophrenia: A Retrospective Case Series Study

“…Preliminary evidence for the eff ectiveness of memantine as add-on therapy emanated from 2 case reports which showed rapid clinical improvement of hyperactivity in patients with catatonic schizophrenia following addition of memantine to ongoing treatment with clozapine [ 13 , 14 ] . Adjunctive therapy with memantine allowed reduction of dosage of the ongoing antipsychotic medication in elderly patients with schizophrenia by ameliorating aggressive behaviors [ 15 ] as well as negative symptoms [ 16 ] . Sig-Introduction ▼ N-Methyl -D-Aspartate receptor (NMDAR) hypofunction and aberrant glutamatergic signalling occupy a central position in current formulations of the schizophrenia pathophysiological process [ 1 -3 ] .…”