Sertralina e pancreatite aguda: relato de caso

Abstract

Acute pancreatitis is a severe disease with considerable morbidity and mortality. The incidence of acute pancreatitis is rising in Western countries.1 Gallstones and alcohol consumption are the most important risk factors. Other risk factors include hyperlipidemia, hypercalcemia and trauma. In 10-25% of the patients with acute pancreatitis, no obvious risk factors are present.2 Drugs are also associated with the event and pathogenesis of drug-induced acute pancreatitis has not been yet completely clarified. Case-ReportA previously healthy 55-year-old woman was admitted to treatment for depression. She had quit smoking for five months and developed depressive symptoms (anhedonia, sexual im- Abstract Keywords Resumo DescritoresAcute pancreatitis is a severe disease with considerable morbidity and mortality. Many risk factors are causally related to acute pancreatitis. In this report, a case of acute pancreatitis with possible causal relationship with the use of a selective serotonin reuptake inhibitor, sertraline, will be discussed. After one month of treatment with sertraline, a female patient, 55 years-old, developed a severe abdominal pain and showed a serum amylase elevation. She was admitted to the hospital and the use of sertraline was interrupted. After that, the symptoms remitted and the serum amylase level returned to normal. Because of the potential severity of this disease and the widespread use of sertraline, this association should be reminded when investigating possible causes for acute pancreatitis.Case report. Acute pancreatitis. Sertraline. Selective serotonin reuptake inhibitors.

The Risk of Acute Pancreatitis and Selective Serotonin Reuptake Inhibitors Use: A Meta-Analysis of Case–Control Studies

“…Therefore, spontaneous report of adverse drug reaction, case series, or case report remains to be the first choice to add evidence to the pharmacovigilance databases, as previous reports have shown. [11][12][13] There are not any obvious clinical features to definitely distinguish drug-related acute pancreatitis from other cause-related acute pancreatitis. Drug-related acute pancreatitis remains a diagnostic challenge.…”

“…Till now, case reports and case series have shown the potential association between the risk of acute pancreatitis and selective serotonin reuptake inhibitors use. [11][12][13] Several systematic studies have investigated such an association, [14][15][16] but the results were not consistent. Some studies showed a positive association, 14,16 but others showed no association.…”

Correlation of Modified Computed Tomography Severity Index with Biochemical Markers in Acute Pancreatitis

“…Amylase was first used as a laboratory test for pancreatic disorders in 1916. 1 Because of its short half-life, the serum amylase level decreased sooner than other pancreatic enzymes and returned to normal despite persistence of inflammation 2 and also had a low specificity for AP. Serum Lipase was another commonly used biochemical marker for diagnosis of AP.…”

Hyperamylasemia Related to Sertraline

“…2) Only 1 case of pancreatitis caused by sertraline has been reported. 1) Although it has been reported that selective serotonin reuptake inhibitors may rarely cause pancreatitis, 2) Elevated serum amylase levels associated with sertraline use in cases without pancreatitis has not been reported in the literature. To our knowledge, our case is the first report of hyperamylasemia related to sertraline.…”

“…Elevation of serum amylase level is usually associated with pancreatitis, 1) but 2% of cases are associated with medication. 2) Only 1 case of pancreatitis caused by sertraline has been reported.…”