Basal ganglia hemorrhagic ablation associated with temporary suppression of obsessive-compulsive symptoms

Yaryura-Tobias, José A.; Neziroglu, Fugen

doi:10.1590/s1516-44462003000100008

Cited by 11 publications

(5 citation statements)

References 19 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…“Secondary OCD” can result from lesions of the basal ganglia (Carmin et al, 2002), particularly in the head of the caudate (Chacko et al, 2000), or from infarct or injury to the left or right OFC (Kim and Lee, 2002; Ogai et al, 2005). Conversely, there are also striking cases in which patients with longstanding, intractable OCD have showed marked improvement in symptoms following basal ganglia hemeorrhage affecting the OFC-striatal circuit (Yaryura-Tobias and Neziroglu, 2003; Fujii et al, 2005). …”

Section: Abnormalities Of Ofc-striatal Function In Psychiatric Illnessmentioning

confidence: 99%

Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal Cortex: Promising Therapeutic Targets in Psychiatric Illness

Fettes

Schulze

Downar

2017

Front. Syst. Neurosci.

223

145

View full text Add to dashboard Cite

Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex human behaviors such as evaluation, affect regulation and reward-based decision-making. Importantly, the medial and lateral OFC (mOFC and lOFC) circuits have functionally and anatomically distinct connectivity profiles which differentially contribute to the various aspects of goal-directed behavior. OFC corticostriatal circuits have been consistently implicated across a wide range of psychiatric disorders, including major depressive disorder (MDD), obsessive compulsive disorder (OCD), and substance use disorders (SUDs). Furthermore, psychiatric disorders related to OFC corticostriatal dysfunction can be addressed via conventional and novel neurostimulatory techniques, including deep brain stimulation (DBS), electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS). Such techniques elicit changes in OFC corticostriatal activity, resulting in changes in clinical symptomatology. Here we review the available literature regarding how disturbances in mOFC and lOFC corticostriatal functioning may lead to psychiatric symptomatology in the aforementioned disorders, and how psychiatric treatments may exert their therapeutic effect by rectifying abnormal OFC corticostriatal activity. First, we review the role of OFC corticostriatal circuits in reward-guided learning, decision-making, affect regulation and reappraisal. Second, we discuss the role of OFC corticostriatal circuit dysfunction across a wide range of psychiatric disorders. Third, we review available evidence that the therapeutic mechanisms of various neuromodulation techniques may directly involve rectifying abnormal activity in mOFC and lOFC corticostriatal circuits. Finally, we examine the potential of future applications of therapeutic brain stimulation targeted at OFC circuitry; specifically, the role of OFC brain stimulation in the growing field of individually-tailored therapies and personalized medicine in psychiatry.

show abstract

Section: Abnormalities Of Ofc-striatal Function In Psychiatric Illnessmentioning

confidence: 99%

Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal Cortex: Promising Therapeutic Targets in Psychiatric Illness

Fettes

Schulze

Downar

2017

Front. Syst. Neurosci.

223

145

View full text Add to dashboard Cite

show abstract

“…Multiple reports describe cases of OCD following lesions confined to the basal ganglia (Carmin, Wiegartz, Yunus, & Gillock, 2002;Chacko, Corbin, & Harper, 2000;Laplane et al, 1989;Lopez-Rodriguez, Gunay, & Glaser, 1997;Rodrigo Escalona, Adair, Roberts, & Graeber, 1997;Weilburg et al, 1989;Weiss & Jenike, 2000); two describe cases following lesions confined to the OFC (Kim & Lee, 2002;Ogai, Iyo, Mori, & Takei, 2005); a few describe cases following lesions involving broader expanses of frontal cortex (Swoboda & Jenike, 1995;Ward, 1988;Weiss & Jenike, 2000); and a few others describe cases following more widespread lesions, which nonetheless also involve the frontal lobes (typically including the OFC) or the basal ganglia (Berthier, Kulisevsky, Gironell, & Lopez, 2001;Gamazo-Garran, Soutullo, & Ortuno, 2002;Max et al, 1995). In addition, two case reports describe improvements in preexisting OCD after hemorrhage in the basal ganglia (Fujii, Otsuka, Suzuki, Endo, & Yamadori, 2005;Yaryura-Tobias & Neziroglu, 2003).…”

Section: Ocd As a Consequence Of Brain Injurymentioning

confidence: 99%

The neural bases of obsessive–compulsive disorder in children and adults

2008

View full text Add to dashboard Cite

Functional imaging studies have reported with remarkable consistency hyperactivity in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and caudate nucleus of patients with Obsessive-Compulsive Disorder (OCD). These findings have often been interpreted as evidence that abnormalities in cortico-basal ganglia-thalamo-cortical loops involving the OFC and ACC are causally related to OCD. This interpretation remains controversial, however, because such hyperactivity may represent either a cause or a consequence of the symptoms. This article analyzes the evidence for a causal role of these loops in producing OCD in children and adults. The article first reviews the strong evidence for anatomical abnormalities in these loops in patients with OCD. These findings are not sufficient to establish causality, however, because anatomical alterations may themselves be a consequence rather than a cause of the symptoms. The article then reviews three lines of evidence that, despite their own limitations, permit stronger causal inferences: the development of OCD following brain injury, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection, and neurosurgical lesions that attenuate OCD. Converging evidence from these various lines of research supports a causal role for the cortico-basal ganglia-thalamo-cortical loops that involve the OFC and ACC in the pathogenesis of OCD in children and adults.

show abstract

“…In a 33-year-old man with a previous history of OCD, contamination and aggressive obsessions disappeared totally following a haemorrhagic infarction in the left basal ganglia. A few months later, his OCS symptoms gradually relapsed [22]. Here, we present a case of OCD whose symptoms resolved within a few days after a haemorrhage in the left temporo-parieto-occipital lobes.…”

Section: Introductionmentioning

confidence: 84%

Remission of obsessive-compulsive symptoms following temporoparietal haemorrhage: a case report

Şair

Canazlar

et al. 2017

Psychiatry and Clinical Psychopharmacology

View full text Add to dashboard Cite

Many etiological factors have been implicated in the pathophysiology of obsessive-compulsive disorder (OCD). The non-invasive neuroimaging studies regarding the pathophysiology of OCD indicate the abnormalities in distinct brain regions. Cortico-striato-thalamo-cortical (CSTC) tracts are proposed to be involved in OCD symptomatology. Reports of OCD cases after a brain injury including cerebrovascular accident (CVA) also support the involvement of CSTC pathways in OCD. Moreover, a few cases of OCD whose OC symptoms displayed an improvement after CVA in the brain regions related CSTC tracts. These reports will guide the surgical interventions in OCD. Here, we present a case of OCD whose symptoms resolved within a few days after a haemorrhage in the left temporo-parieto-occipital lobes. In this case, we supposed that the compression of the subcortical striatal tissues which is known to be involved in the OCD pathophysiology might be associated with the resolution of OCD symptoms.

show abstract

Basal ganglia hemorrhagic ablation associated with temporary suppression of obsessive-compulsive symptoms

Cited by 11 publications

References 19 publications

Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal Cortex: Promising Therapeutic Targets in Psychiatric Illness

Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal Cortex: Promising Therapeutic Targets in Psychiatric Illness

The neural bases of obsessive–compulsive disorder in children and adults

Remission of obsessive-compulsive symptoms following temporoparietal haemorrhage: a case report

Contact Info

Product

Resources

About