The role of oxidative stress in small ruminants' health and production

Celi, Pietro

doi:10.1590/s1516-35982010001300038

Cited by 168 publications

(153 citation statements)

References 156 publications

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…Dietary supplementation with vitamin E or vitamin D3 can increase the levels of GSH in the liver (Sardar et al 1996). MDA, the main representative of the thiobarbituric acid-reactive substances that arises during the peroxidation of fatty acids by ROS, is considered to be a marker of cellular damage and oxidative stress because its concentration increases with excess ROS (Celi 2010). In the present study, the lowest post-weaning levels of GSH were found in the treated group.…”

Section: Discussionsupporting

confidence: 46%

See 1 more Smart Citation

Parenteral administration of vitamins A, D and E on the oxidative metabolism and function of polymorphonuclear leukocytes in swine

et al. 2012

View full text Add to dashboard Cite

Pesq. Vet. Bras. 32(8) The weaning period of piglets is characterized by physiological alterations, such as decreased weight gain, increased reactive oxygen species (ROS) and increased serum cortisol levels with possible effects on the immune response. The effect of parenteral administration of vitamins A, D and E on production performance, oxidative metabolism, and the function of polymorphonuclear leukocytes (PMNLs) was assessed in piglets during the weaning period. The sample was comprised of 20 male piglets that were given an injectable ADE vitamin combination (135,000 IU vitamin A, 40,000 IU vitamin D and 40mg vitamin E/ animal) at 20 and 40 days of age. Weight gain, concentration of reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD) and the microbicidal and phagocytic activity of PMNLs were assessed. No difference was observed in the average piglet weight during the study; however, a greater percentage of weight gain was observed after weaning in the treated group. The concentrations of GSH and SOD did not differ between groups, although lipid peroxidation was greater in the control group at 60 days of age. The investigated variables of oxidative metabolism were correlated as follows: -0.41 for GSH and MDA, -0.54 for GSH and SOD and 0.34 for MDA and SOD. The intensity of intracellular ROS production, the percentage of ROS-producing PMNLs and the intensity of phagocytosis by PMNLs did not differ between treatment groups. Administration of the injectable ADE combination improved the percentage of weight gain between 20 and 40 days of age, decreased oxidative stress at 60 days of age and did not inϐluence the function of PMNLs in piglets.INDEX TERMS: Immune response, weaning, piglets, GSH, MSD and SOD. lógicas como menor ganho de peso, aumento na produção de espécies reativas de oxigênio (EROs) e aumento na concentração plasmática de cortisol com possíveis implicações para a resposta imune. Foi avaliado o efeito da administração parenteral das vitaminas A, D e E sobre o desempenho produtivo, o metabolismo oxidativo e a função de leucócitos polimorfonucleares (PMNLs) em suínos durante esta fase de crescimento. Foram utilizados 20 leitões, machos, com 20 dias de idade que receberam ADE injetável (135.000 UI vitamina A, 40.000 UI vitamina D e 40mg vitamina E/animal), aos 20 e 40 dias de idade. Foi determinado o ganho de peso e as concentrações de glutationa reduzida (GSH), malondialdeído (MDA) e superóxido dismutase (SOD) e a

show abstract

Section: Discussionsupporting

confidence: 46%

“…SOD, an endogenous antioxidant, belongs to the class of metalloenzymes that counteract superoxide anion toxicity (Celi 2010). SOD is the most abundant enzymes and is the ϐifth most abundant protein in quantitative terms.…”

Section: Discussionmentioning

confidence: 99%

Parenteral administration of vitamins A, D and E on the oxidative metabolism and function of polymorphonuclear leukocytes in swine

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In our study, an increase on oxidative stress in plasma during the follicular phase of the estrous cycle may be closely related to the oxygen demand as a result of cell growth and synthesis activity [20] . In addition, lipids, especially due to compositional properties of LDL-C, are one of the most susceptible substrates to lipid peroxidation [22] . Because of LDL-C susceptibility to oxidation, its high level may be a reason of increased oxidative stress at the follicular phase of the estrous cycle.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Estrous Cycle on Oxidant and Antioxidant Parameters in Dairy Cows

Aydılek¹,

Varışlı²,

Selek³

et al. 2014

Kafkas Univ Vet Fak Derg

View full text Add to dashboard Cite

Reactive oxygen species have fundamental roles in reproductive functions. To comprehensively evaluate the relation between reactive oxygen species and infertility, physiological variations across the estrous cycle in healthy cows have to be known. For this purpose 25 healthy multiparous Holstein dairy cows having regular estrous cycles were used. The estrous cycles were synchronized by ovsynch protocol. Oxidant [lipid hydroperoxide (LOOH), total oxidant status (TOS), oxidative stress index (OSI)], antioxidant parameters [total antioxidant status (TAS), total free sulfhydryl groups (SH), ceruloplasmin (CP), paraoxonase-1 (PON1), arylesterase (ARE), uric acid (UA)], lipid profile and progesterone levels were assayed at estrus, metestrus, diestrus and proestrus stages of the estrous cycle in the plasma samples. The plasma levels of oxidant (LOOH, TOS and OSI) and antioxidant (TAS, SH and UA) parameters were significantly decreased during the luteal phase compared to the follicular phase (at proestrus and at estrus) of the estrous cycle. There was also a significant positive correlation between TAS and TOS. The activity of PON1 and ARE significantly increased only at diestrus. Levels of high density lipoprotein, low density lipoprotein and total cholesterol elevated during the follicular phase (estrus) and declined during the luteal phase. In conclusion, oxidant/antioxidant status and lipid profile were affected by cyclic changes. Moreover, antioxidant defense system showed adaptive response to increased oxidative activities by occurring parallel increases and it may indicate that there is a dynamic balance between oxidant and antioxidant status during the estrous cycle in healthy cows. Keywords: Cow, Estrous cycle, Lipid peroxide, Lipid profile, Total antioxidant status, Total oxidant status Sütçü İneklerde Östrus Siklusunun Oksidan ve Antioksidan Parametreler Üzerine Etkisi ÖzetReaktif oksijen türlerinin üreme fonksiyonları üzerinde önemli rolleri vardır. Sağlıklı süt sığırlarında reaktif oksijen türleri ve infertilite arasındaki ilişkiyi kapsamlı bir şekilde değerlendirmek için östrus siklusu boyunca reaktif oksijen türü seviyelerindeki değişimlerin bilinmesi gerekir. Bu çalışmada düzenli siklus gösteren 25 adet sağlıklı Holştayn ırkı sütçü inek kullanıldı. Östrus siklusları ovsynch protokolü ile senkronize edildi. Östrus siklusunun proöstrus, östrus, metaöstrus ve diöstrus dönemlerinde kan plazmasında oksidan parametreler [lipit hidroperoksit (LOOH), total oksidan seviye (TOS), oksidatif stres indeksi (OSI)], antioksidan parametreler [total antioksidan kapasite (TAS), total serbest sülfhidril gruplar (SH), seruloplazmin (CP), paraoksonaz-1 (PON1), arilesteraz (ARE), ürik asit (UA)], lipit profili ve progesteron seviyesi ölçüldü. Foliküler dönemle karşılaştırıldığında luteal dönemdeki plazma oksidan (LOOH, TOS, OSI) ve antioksidan (TAS, SH, UA) seviyelerinin önemli derecede düştüğü görüldü. Ayrıca TAS ve TOS değerleri arasında önemli bir pozitif korelasyon vardı. Paraoksonaz-1 ve ARE aktiviteleri sadece diöstrus ...

show abstract

“…The inhibitory effect of PGF2α on progesterone production by the CL is due in part to increased ROS. In addition, progesterone levels decrease due to the destructive effects of oxidative stressors on luteal cell steroidogenesis [116][117][118]. ROS can also inhibit progesterone synthesis through inhibition of cytochrome P450, mitochondrial intracellular transport of cholesterol, and degradation of LH receptors [112].…”

Section: Relationship Between Progesterone and Oxidative Stress In Rumentioning

confidence: 99%

“…In sheep, the regulation of reproductive physiology is related to the effects of oxidative stress [117]. Increased levels of progesterone during pregnancy in sheep and goats as well as increased levels of malondialdehyde (MDA) in placentomas have been reported [131].…”

Section: Relationship Between Progesterone and Oxidative Stress In Rumentioning

confidence: 99%

Clinical Use of Progesterone and Its Relation to Oxidative Stress in Ruminants

Kuru¹,

Kükürt²,

Oral³

et al. 2018

Sex Hormones in Neurodegenerative Processes and Diseases

View full text Add to dashboard Cite

Studies to determine the physiological effects and functions of progesterone started in the twentieth century. Progesterone is a steroid-structured hormone with 21 carbon atoms originating from cholesterol. The corpus luteum, formed after ovulation in ruminants, secretes progesterone, which plays a role in the continuity of the pregnancy. Progestagens can be used for estrus synchronization in cows and heifers. Similarly, they are used for estrus synchronization during the breeding season or outside the breeding season by taking advantage of the negative feedback effect of progesterone in small ruminants. It is applied for the treatment of embryonic deaths due to luteal insufficiency in cows with high milk yield. In anovulatory anestrus, exogenous progesterone applications can be very useful. Progesterone treatment contributes to the resolution of the anestrus by rearranging hypothalamic functions in cattle with follicular cysts. The oxidative stress index in the luteal phase, when progesterone is high in ruminants, is higher than in the follicular phase. In the critical period of pregnancy, a high index of oxidative stress-induced progesterone causes embryonic death. Factors that cause stress in high milk-yielding cows can affect the amount of progesterone synthesis by inhibiting luteal cell function due to excessive free radical production.

show abstract

The role of oxidative stress in small ruminants' health and production

Abstract: This paper examines the role that oxidative stress plays in small ruminant medicine. We will examine how redox homeostasis is involved in some physiological functions and we will discuss the implications of the impairment of oxidative status on small ruminant health and production.

Cited by 168 publications

References 156 publications

Parenteral administration of vitamins A, D and E on the oxidative metabolism and function of polymorphonuclear leukocytes in swine

Parenteral administration of vitamins A, D and E on the oxidative metabolism and function of polymorphonuclear leukocytes in swine

The Effect of Estrous Cycle on Oxidant and Antioxidant Parameters in Dairy Cows

Clinical Use of Progesterone and Its Relation to Oxidative Stress in Ruminants

Contact Info

Product

Resources

About