Mucosa-associated lymphoid tissue lymphoma of the trachea: case report

Magliari, Maria Elisa Ruffolo; Aquino, Renata Telles Rudge de; Gonçalves, Anna Luiza Lobão; Marioni, Fabio; Bernardi, Fabı́ola Del Carlo; Brasil, Sérgio; Almeida, Joaquim Antonio da Fonseca; Andrade, Benedito Juarez; Chiattone, Carlos S.; Lima, Carlos Alberto da Conceição

doi:10.1590/s1516-31802012000200010

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…Химиотерапевтические и иммуноонкологические препараты редко использовались как часть лечения первой линии MALT-лимфомы начальной стадии, поскольку местная терапия способна обеспечить длительный безрецидивный период [24]. Однако в настоящее время опубликовано большое количество статей, описывающих успешное лечение ранних стадий MALT-лимфом с помощью химиоиммунотерапии [25][26][27]. В частности, ритуксимаб показал 70 % ответ при MALT-лимфоме, независимо от локализации опухоли [28].…”

Section: Discussionunclassified

Primary malt-tracheal lymphoma: case report

et al. 2022

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Background. Tracheal cancer accounts 2 % of all upper respiratory tract cancers, with the incidence of 0.1 cases per 100,000 people per year. Primary tracheal MALT-lymphoma is extremely rare, and therefore there is no clearly established approach to the treatment of this disease. There are several effective positions regarding the choice of therapy. This article discusses the feasibility of endoscopic surgical treatment of primary tracheal lymphoma. The review of the literature presents current data on the epidemiology, etiopathogenesis, clinical features and treatment strategy for this disease. Description of the clinical case. A 72-year-old patient was admitted to the Thoracic Surgical Department of the P.A. Hertzen Cancer Research Center with complaints of shortness of breath with moderate physical exertion and dry cough. The examination revealed a tumor in the upper third of the trachea showing an exophytic growth, and grade I–III tracheal stenosis. To restore the lumen of the trachea and prevent complications, the endoscopic resection of the exophytic part of the tumor was performed. Histological and immunohistochemical studies revealed MALT-lymphoma of the trachea. Taking into consideration the indolent form of lymphoma, small size of the tumor, patient’s age and comorbidity, there were no indications for systemic anticancer therapy. The patient was recommended to be followed up. The patient is alive with no evidence of disease recurrence. Conclusion. This case report demonstrates the feasibility of performing organ-preserving endoscopic surgery in the patient with primary tracheal MALT-lymphoma. Taking into consideration the exophytic form of the tumor growth, endoscopic surgery made it possible to avoid unnecessary open tracheal resection, thus signifcantly improving the quality of life of the patient.

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Section: Discussionunclassified

Primary malt-tracheal lymphoma: case report

et al. 2022

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“…[ 2 , 5 ] Among them, hematopoietic tumors are rare and principally comprise plasmocytoma and non-Hodgkin lymphoma. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

“…Many case reports revealed the effectiveness of chemotherapy including rituximab. [ 6 , 17 ] Rituximab (anti-CD 20 monoclonal antibody) has shown a 70% response rate in MALT lymphoma irrespective of the disease site. [ 1 ]…”

Section: Discussionmentioning

confidence: 99%

Mucosa-associated lymphoid tissue lymphoma of the trachea associated with idiopathic pulmonary fibrosis

Ahn

Chung²,

Shin³

et al. 2018

Medicine

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Rationale:Mucosa-associated lymphoid tissue (MALT) lymphoma of the trachea is a rare disease that has been shown to be associated with chronic antigenic stimulation. There have been few reports of MALT lymphoma of the trachea in association with idiopathic pulmonary fibrosis (IPF).Patient concerns:A 73-year-old patient visited with a 2-year history of dyspnea on exertion and productive cough, which had worsened 1 month ago.Diagnoses:MALT lymphoma of the trachea associated with IPF.Interventions:After taking into consideration the age, poor performance status, and comorbidities of the patient and the extent of disease, we utilized an observational approach as a treatment strategy.Outcomes:The patient is well without any evidence of progression for 12 months since the initial diagnosis.Lessons:We present a case of MALT lymphoma of the trachea associated with IPF. A common predisposing factor may exist for tracheal MALT lymphoma and IPF. As there are no randomized clinical trials focusing on tracheal MALT lymphoma, individualized treatment decision is important, and in some cases, simply monitoring the patient might be the most appropriate approach.

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“…[8] MALT lymphomas of the parotid gland are rare, [9] as are MALT lymphomas of the trachea and bronchus. [10,11]…”

Section: Introductionmentioning

confidence: 99%