Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review

Abstract

CONTEXT: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. CASE REPORT: This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. CONCLUSIONS:No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.resUMo CONTEXTO: Paragangliomas extra-adrenais são tumores raros que têm sido relatados em muitas localizações, incluindo rim, uretra, bexiga, próstata, cordão espermático, vesícula biliar, útero e vagina. RELATO DE CASO: Este relato descreve, pela primeira vez em nosso conhecimento, um paraganglioma primário da vesícula seminal ocorrendo em um paciente do sexo masculino de 61 anos de idade. O paciente apresentou hipertensão arterial persistente e um diagnóstico prévio de carcinoma de células renais cromófobo (CCRC). Foi pensado que o tumor de vesícula seminal poderia ser uma metástase do CCRC. A caracterização imunoistoquímica revelou expressão de sinaptofisina e cromogranina nos ninhos de células tumorais e expressão de proteína S100 nas células sustentaculares. Expressão de succinato de-hidrogenase A e B relacionada (SDHA e SDHB) estiveram presentes em ambos os tumores. CONCLUSÕES: Nenhuma alteração genética dos genes VHL e SDHB foi detectada nos tecidos tumorais e adjacentes ao tumor, o que nos levou a afastar uma síndrome hereditária que poderia explicar a associação entre o paraganglioma e o CCRC em um paciente com hipertensão arterial.

Paraganglioma of the Seminal Vesicle Case Report and Review of the Literature

“…The clinical presentation and symptoms: one case presented with signs of acute appendicitis, 7 one case presented with history of chromophobe renal-cell carcinoma and during a routine follow-up evaluation revealed tumor in the seminal vesicle, 6 PSA level was measured only in our case and was normal, upper urinary tract obstruction (UUTO) was present in the current case, no signs of hematuria, hematospermia, metastatic disease, or genetic mutation were presented. LUTS were at the present case and for the other three cases were not present.…”

Paraganglioma of the vagina: a case report and review of the literature

“…However, it cannot be determined just by histological morphology. Instead, it should be judged malignant on the bases of neoplasm recurrence, metastasis of lymph nodes or nonchromaffin tissues, and invasion or infiltration to the adjacent apparatus 29–31. Due to the possibility of neoplasm recurrence and metastasis, as reported, patients need periodic checks and long-term follow-up 27,31.…”

Succinat-Dehydrogenase(SDH)-defizientes Nierenzellkarzinom

“…B. das SDH-assoziierte Onkozytom [13]bzw. das chromophobe NZKbeieinem PatientenmitParagangliom der Samenblase [1] nicht besser in das stereotypische Spektrum des SDH-NZK passen würden. Unter Berücksich-tigung der oben beschriebenen Morphologie SDH-defizienter NZK bleibt es sehr wohl möglich, dass das SDH-NZK in der Vergangenheitüberwiegend indie Onkozytomgruppe bzw.…”