Oral zinc for treating diarrhoea in children

Lazzerini, Marzia; Ronfani, Luca

doi:10.1590/s1516-31802011000200013

Cited by 11 publications

(1 citation statement)

References 2 publications

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“…Another critical problem to handle is diarrhea in children, especially in low-income countries. Not only zinc could boost the antioxidant response to cope with pathogens ( 97 ), but also maintain the integrity of the cell membrane ( 98 ) and block the potassium secretion through chlorine secretion ( 98 ). In this way, diarrhea in children can be to some certain extent inhibited by oral zinc in the intestines.…”

Section: Discussionmentioning

confidence: 99%

Zinc Intakes and Health Outcomes: An Umbrella Review

Cao

Huang

et al. 2022

Front. Nutr.

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It is widely accepted that the zinc element is crucial in human beings. Zinc has gained more attention during the COVID-19 pandemic due to its utilization for the treatment and prevention of respiratory tract infections. However, some studies also pointed out that zinc intake might cause unwanted side effects and even be dangerous when overdosed. To reveal the relationship between zinc intake and health outcomes, we performed an umbrella review from human studies. In total, the umbrella review included 43 articles and identified 11 outcomes for dietary zinc intake and 86 outcomes for supplementary zinc intake. Dietary zinc intake in the highest dose would decrease the risk of overall and specific digestive tract cancers, depression, and type 2 diabetes mellitus (T2DM) in adults. Supplementary zinc consumption in adults was linked to an improvement of depression, antioxidant capacity and sperm quality, higher serum zinc concentration, and lower concentration of inflammatory markers. Zinc supplementation in children would reduce the incidence of diarrhea and pneumonia, improve zinc deficiency and boost growth. However, zinc might not decrease all-cause mortality in adults or the in-hospital mortality of COVID-19. And better maternal and neonatal outcomes may not derive from pregnant women who consumed higher or lower doses of zinc supplementation (>20 mg/day and <20 mg/day, respectively). Dose-response analyses revealed that a daily 5 mg increment of zinc would lower the risk of colorectal and esophageal cancer, whereas a large dose of zinc supplementation (daily 100 mg) showed no benefit in reducing prostate cancer risk.

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Section: Discussionmentioning

confidence: 99%

Zinc Intakes and Health Outcomes: An Umbrella Review

Cao

Huang

et al. 2022

Front. Nutr.

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Zinc Supplementation Modifies Tight Junctions and Alters Barrier Function of CACO-2 Human Intestinal Epithelial Layers

et al. 2012

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Effects of Zinc Combined with Probiotics on Antibiotic-associated Diarrhea Secondary to Childhood Pneumonia

Xiang

Tang

Chen

et al. 2018

Journal of Tropical Pediatrics

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Aim The aim of this study was to evaluate the impact of zinc combined with probiotics (Bifico) on antibiotic-associated diarrhea (AAD) secondary to pneumonia. Methods A total of 50 patients with AAD secondary to pneumonia were randomly divided into a probiotics group (Bifico) and a combined group (zinc combined with Bifico) and 25 pneumonia patients without AAD as the control group. Serum levels of zinc, diamine oxidase (DAO) activity, D-lactate and intestinal flora [Bifidobacterium, Escherichia coli and Bifidobacterium/E. coli (B/E) ratio] were detected before and after intervention. Results The results showed that zinc combined with Bifico had significantly higher overall efficiency than Bifico alone for treatment of AAD secondary to pneumonia. Notably, the combined treatment increased the population of Bifidobacterium, while the number of E. coli was reduced, the B/E value was improved and DAO activity and D-lactate levels were markedly reduced. Conclusion Patients with AAD secondary to pneumonia benefit from zinc supplementation of probiotic treatment.

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Oral zinc for treating diarrhoea in children

Cited by 11 publications

References 2 publications

Zinc Intakes and Health Outcomes: An Umbrella Review

Zinc Intakes and Health Outcomes: An Umbrella Review

Zinc Supplementation Modifies Tight Junctions and Alters Barrier Function of CACO-2 Human Intestinal Epithelial Layers

Effects of Zinc Combined with Probiotics on Antibiotic-associated Diarrhea Secondary to Childhood Pneumonia

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