Bcl-2 protein in diffuse large B-cell lymphoma

Abstract

Bcl-2 protein in diffuse large B-cell lymphoma Proteína Bcl-2 em linfoma difuso de grandes células B Viroj Wiwanitkit I Dear Editor, I read the recently published paper on Bcl-2 with great interest. 1 Hallack Neto et al. concluded that "Bcl-2 protein was expressed in 37% of the high-risk DLBCL patients, without any difference between the ABC-like DLBCL and GCB-like DLBCL cases. 1 " Indeed, the clinical value of determining Bcl-2 in B-cell lymphoma is still controversial. However, there are some problems in this work. The retrospective cohort design is not a common approach. There is also no risk classification from the analysis. The small number of subjects in this work might not be statistically acceptable for any conclusion.