Low-cost outpatient chemotherapy regimen of cisplatin, 5-fluorouracil and leucovorin for advanced head and neck and esophageal carcinomas

Fabricio, Vanessa; Amado, Fernanda; Giglio, Auro del

doi:10.1590/s1516-31802008000100012

Cited by 6 publications

(1 citation statement)

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“…Para Ostene et al, (2008) A QT constitui uma parte importante do tratamento multidisciplinar para os pacientes com câncer de cabeça e pescoço e esôfago, em que frequentemente é empregado um esquema quimioterápico constituído por 4 a 5 dias de infusão continua de 5-FU in bolus com cisplatina (FABRÍCIO et al, 2008). Esta combinação em associação a RT resulta em um método altamente eficaz no controle do câncer de cabeça e pescoço, porém a mesma esta associada a um aumento na incidência de MO grau 3 e 4 e de efeitos hematológicos tóxicos (SEIWERT et al,.…”

Section: Quimioterapiaunclassified

Tratamento da mucosite oral radio e quimioinduzida: comparação entre protocolo medicamentoso convencional e tratamentos com lasers em baixa intensidade

Alencar¹

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In this clinical study verified the effects of low intensity laser in the prevention and treatment of oral mucositis radio and/or chemical induced. Thirty one patients with head and neck cancer were selected before being submitted to cancer exclusive radiotherapy or radio and associated chemotherapy. The patients were distributed into three randomly groups as follows: group 1-(control) conventional medicine treatment; group 2conventional medicine treatment and daily lasertherapy as soon as grade two oral mucositis appeared; group 3conventional medicine treatment and daily lasertherapy to be initiated immediately before radiotherapy sessions.The irradiation parameters were: wavelength of 660nm, potency of 100mW, continuous mode, punctual application, 2J energy on thirty predetermined 30 points, with 20s of exposure per point. The control group received medical treatment which consisted in using a set of preventive and therapeutic approach for acute radiation-induced adverse effects. Results were evaluated observing occurrence and grade of oral mucositis, score of pain, loss of body mass, use of nasogastric sound line, internment and interruption of oncologic treatment due to oral mucositis. The results showed that the preventive protocol as used was the most effective in prevention and treatment of oral mucositis and that its daily application contributed in relieving the painful symptomatology so collaborating to maintain and/or bettering the life quality of oncologic patients.

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Section: Quimioterapiaunclassified