Description of a neural sheath tumor of the trigeminal nerve: immunohistochemical and electron microscopy study

Khademi, Bijan; Owji, Seyed Mohammad; Khosh, Khadije Jamshidi; Mohammadianpanah, Μohammad; Gandomi, Behrooz

doi:10.1590/s1516-31802006000600006

Cited by 7 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These 29 articles provided 35 cases, to which we added 1 additional case from our institu tion. 1,2,[4][5][6][7][8]10,11,[14][15][16][17][18][19][20][21]24,[26][27][28][29][30][32][33][34][35][36][37] The complete results of our analysis of 36 cases are detailed in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Malignant peripheral nerve sheath tumors of the trigeminal nerve: a systematic review of 36 cases

Schmidt¹,

Yick²,

Boghani³

et al. 2013

FOC

View full text Add to dashboard Cite

Object Malignant peripheral nerve sheath tumors (MPNSTs) are a rare form of malignancy arising from the Schwann cells of peripheral nerves. MPNSTs of the trigeminal nerve are exceptionally rare, with only a handful of reports in the literature. These tumors are typically very aggressive, resulting in significant patient morbidity and a generally grim prognosis. Most current reports suggest that radical resection with radiation therapy offers the best benefit. In this study, the authors systematically reviewed the world English-language literature on MPNSTs of the trigeminal nerve to analyze the presentations, treatment options, and outcomes for patients with this disease. Methods A literature search for MPNSTs of the trigeminal nerve confined to nonanimal, English-language articles was conducted utilizing the PubMed database, with additional cases chosen from the references of selected articles. Only cases of confirmed MPNSTs of the trigeminal nerve or its peripheral branches, based upon surgical, pathological, or radiological analysis, were included. Results From the literature search, 29 articles discussing 35 cases of MPNSTs of the trigeminal nerve were chosen. With the addition of 1 case from their own institution, the authors analyzed 36 cases of trigeminal MPNSTs. The average age of onset was 44.6 years. These tumors were more commonly seen in male patients (77.1%). The gasserian ganglion was involved in 36.1% of the cases. Of the cases in which the nerve distribution was specified (n = 25), the mandibular branch was most commonly involved (72.0%), followed by the maxillary branch (60.0%) and the ophthalmic branch (32.0%), with 44.0% of patients exhibiting involvement of 2 or more branches. Altered facial sensation and facial pain were the 2 most commonly reported symptoms, found in 63.9% and 52.8% of patients, respectively. Mastication difficulty and diplopia were seen in 22.2% of patients, facial weakness was seen in 19.4%, and hearing loss was present in 16.7%. With regard to the primary treatment strategy, 80.6% underwent resection, 16.7% underwent radiation therapy, and 2.9% received chemotherapy alone. Patients treated with complete resection followed by postoperative radiation therapy had the most favorable outcomes, with no patients showing evidence of disease recurrence with a mean follow-up of 34.6 months. Patients treated with incomplete resection followed by postoperative radiation therapy had more favorable outcomes than patients treated with incomplete resection without radiation therapy or radiation therapy alone. Conclusions Trigeminal MPNSTs most commonly present as altered facial sensation or facial pain, although they exhibit a number of other clinical manifestations, including the involvement of other cranial nerves. While a variety of treatment options exist, due to their highly infiltrative nature, aggressive resection followed by radiation therapy appears to offer the greatest chance of recurrence-free survival.

show abstract

Section: Resultsmentioning

confidence: 99%

Malignant peripheral nerve sheath tumors of the trigeminal nerve: a systematic review of 36 cases

Schmidt¹,

Yick²,

Boghani³

et al. 2013

FOC

View full text Add to dashboard Cite

show abstract

“…Several studies have shown that malignant schwannomas in the nasal cavity, paranasal sinus and nasopharynx are rare 3 , 4 . In the latter region, the ethmoid and maxillary sinuses are most often affected, the nasal fossa and sphenoid sinus come next and the frontal sinus is rarely affected 5 . There are few cases of benign schwannomas in national literature 6 , just Pinto et al 7 cited an unique case of ethmoid malignant schwannoma in a study about nasal and paranasal sinuses malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Individuals in their fourth and fifth decades are more often affected, and there is no preference for sex or race 1 . They can occur alone, but are associated with von Recklinghausens disease in 30% of the cases, and usually evolve from malignant transformation of neurofibroma 1 , 2 , 5 , 8 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Schwannoma maligno dos seios paranasais

Pádua¹,

Soares²,

Queiroz³

et al. 2012

Braz. j. otorhinolaryngol.

View full text Add to dashboard Cite

“…Squamous cell carcinoma, minor salivary gland tumors, and undifferentiated carcinoma are the most common epithelial malignancies in this location. Lymphomas, malignant melanoma, soft tissue sarcoma and olfactory neuroblastoma are the most common nonepithelial pathologies (1)(2)(3). Olfactory neuroblastoma or esthesioneuroblastoma is a rare malignant neuroectodermal neoplasm of the olfactory neuroepithelium.…”

Section: Introductionmentioning

confidence: 99%