Cellular angiofibroma of the vulva: case report with clinicopathological and immunohistochemistry study

Abstract

CONTEXT: Cellular angiofibroma of the vulva is a rare tumor that was first described in 1997. It occurs in middle-aged women (average age: 47 years), has small size (< 3 cm) and well-circumscribed margins. CASE REPORT: We describe a case in a 51-year-old woman whose preoperative diagnosis was confounded with Bartholin's glandular cyst. The neoplasia was well delimited and made up of three characteristic components: fusiform cells forming small fascicles, numerous blood vessels and adipose tissue interspersed between the fusiform cells. The stroma cells were positive for vimentin and negative for CD34, protein S-100, actin and desmin. The differential diagnoses for this tumor include aggressive angiomyxoma, angiomyofibroblastoma, lipoma of fusiform cells, solitary fibrous tumor, perineurioma and leiomyoma.

Cellular Angiofibroma: A Rare Vulvar Tumor Case Report

“…The present patient had a painless vulvar mass, that was misdiagnosed as a Bartholin cyst, which is reported in some other published cases. 6,8 It was a painless lesion in a middleage woman but larger than a typical CA, which are usually reported as small tumors.…”

“…The potential recurrence risk of these lesions is low, as there is only one case of recurrence reported in the literature, and no known malignant transformation. 6,8,10 The lack of long-term data also limits the establishment of adequate surveillance for these patients, so a similar approach to other benign gynecological lesions may be undertaken.…”

A Large Inguinal Angiofibroma: A Rare Entity

“…However,some angiofibromas also reported in subcutaneous tissue chest wall, retroperitoneum and the oral cavity [6][7][8].…”

Angiofibroma celular de vulva: una entidad a investigar

“…El tratamiento de elección es la escisión local con márge-nes amplios de resección, pero no existe mucha información en cuanto al riesgo de recidiva del tumor, aunque ya se han publicado casos de recurrencia tras la exéresis 5,9 . No se han observado casos de metástasis en la literatura 9 .…”