Histological classification of 1,025 cases of Hodgkin's lymphoma from the State of São Paulo, Brazil

Vassallo, José; Paes, Roberto Pinto; Soares, Fernando Augusto; Menezes, Yara; Aldred, Vera Lucia; Ribeiro, Karina de Cássia Braga; Alves, Antônio Corrêa

doi:10.1590/s1516-31802005000300009

Cited by 15 publications

(9 citation statements)

References 8 publications

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“…In general, it is demonstrated that the MC is the most prevalent subtype of HL in underdeveloped countries (Sandoval et al, 2002;Schwartz, 2005). In contrast to our results, Vassallo et al found a 70% incidence of the NS subtype in adults and children patients (Vassallo et al, 2005). In addition, Bazzeh et al showed that the nodular sclerosis (NS) subtype was significantly more common in pediatric age group (Bazzeh et al, 2010).…”

Section: Discussioncontrasting

confidence: 90%

Characteristics of Hodgkin Lymphoma in a Defined Group of Iranian Pediatric Patients

Baharvand

Mortazavi²

2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussioncontrasting

confidence: 90%

Characteristics of Hodgkin Lymphoma in a Defined Group of Iranian Pediatric Patients

Baharvand

Mortazavi²

2014

Asian Pacific Journal of Cancer Prevention

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“…In the 1980s, the nodular sclerosis subtype represented around 50% of the cases of HL examined in Brazil . This proportion increased to around 70% along the following decades . Currently, the nodular sclerosis subtype has reached nearly 75% of all cases of HL.…”

Section: Discussionmentioning

confidence: 99%

Treatment outcomes for Hodgkin lymphoma: First report from the Brazilian Prospective Registry

Biasoli

Castro

Delamain

et al. 2017

Hematological Oncology

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Data about Hodgkin lymphoma (HL) in developing countries are scarce and suggest the existence of substantial disparities in healthcare and outcomes in large areas of the world. In 2009, a prospective registry of HL was implemented in Brazil. Web-based data were contributed by 20 institutions across the country participating in the Brazilian Prospective Hodgkin's Lymphoma Registry. The aim of this study was to present the clinical features and outcomes of newly diagnosed patients with HL aged 13 to 90 years. Multivariate Cox regression models were used to estimate progression-free (PFS) and overall survival (OS) by clinical factors. A total of 674 patients with classical HL were analysed, with a median follow-up of 37 months. Median age was 30 years (13-90). The median time from the onset of symptoms to diagnosis was 6 months (0-60). Only 6% of patients had early favourable disease, while 65% had advanced disease. Stage IVB was present in 26% and a high-risk International Prognostic Score in 38%. Doxorubicin, bleomycin, vinblastine, and dacarbazine was used in 93%. The median dose of radiotherapy was 36 Gy for localized disease and 32 Gy for advanced disease. The 3 year PFS in early favourable, early unfavourable, and advanced disease were 95%, 88%, and 66%, respectively. High-risk International Prognostic Score, advanced disease, and age greater than or equal to 60 were independently associated with poorer PFS and OS; performance status greater than or equal to 2 was also associated with a poorer OS. Poor-risk patients predominated. Radiation doses for localized disease appear higher than current recommendations. Outcomes appear inferior in developing countries than in developed countries. Delayed diagnosis is probably a major factor underlying these findings. Scattered reports from developing nations suggest that many aspects of standard care in developed countries remain unmet needs for populations living in developing countries. The present report contributes to this body of data, with a proper description of what is currently achieved in urban areas in Brazil.

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“…(2,3) There was a predominance of the mixed cellularity subtype (57.4%) consistent with the pattern in developing countries, although in Brazil this is controversial. (3)(4)(5) In this study, the complete remission rate after chemotherapy was projected at 94.1%. OS of 97.0% ± 2.0 and 94.9 ± 3.0%, and EFS of 89.7% ± 3.7% and 87.9 ± 4.0 were observed, respectively at five years and ten years for the entire group of patients.…”

Section: Discussionmentioning

confidence: 82%

Linfoma de Hodgkin na infância e adolescência: 15 anos de experiência com o protocolo DH-II-90

Souza

Maluf

Almeida³

et al. 2010

Rev. Bras. Hematol. Hemoter.

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Histological classification of 1,025 cases of Hodgkin's lymphoma from the State of São Paulo, Brazil

Abstract: The controversy regarding the frequencies of Hodgkin's lymphoma types within the Brazilian setting seems to be due to the small number of cases in previous studies. The present data show a picture close to the situation in the industrialized countries.

Cited by 15 publications

References 8 publications

Characteristics of Hodgkin Lymphoma in a Defined Group of Iranian Pediatric Patients

Characteristics of Hodgkin Lymphoma in a Defined Group of Iranian Pediatric Patients

Treatment outcomes for Hodgkin lymphoma: First report from the Brazilian Prospective Registry

Linfoma de Hodgkin na infância e adolescência: 15 anos de experiência com o protocolo DH-II-90

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