BACKGROUNDDeep Neck Infection (DNI) is a potentially life threatening disease commonly seen in middle aged men. Associated co-morbidities like Diabetes Mellitus, Hypertension and Cardiac diseases result in life threatening complications. DNI are observed in the population who are addiction to drugs, smoking and alcoholism. DNI are associated with complications like mediastinitis, Pneumothorax, pericarditis, renal failure and multi organ failure. The present study is a prospective clinical profile study of DNIs treated in a Tertiary Care Hospital in Kerala. Aim-To describe the profile of aetiology, clinical features and outcomes of patients with DNIs.