In this study, the role of whole body bone scintigraphy has been investigated on patient applied pain palliation theraphy along with Samarium-153 in term of responding to treatment. A 73-year-old male patient diagnosed with lung and rectal cancers and taking chemotheraphy and radiotheraphy complained about his severe back ang leg pain. On whole body bone scintigraphy, increased heterogeneous osteoblastic activity position compitable with bone of skeletal system with metastaes is seen on L1 lumbar spine vertebral process, L2 lumbar spine corpus vertabre, sacrum and left proximal femur. When sixth month and initial scan compared, 40.6% decrease in L1 and L2 vertebral metastases along with 18.4% increase in sacrum metastasid activity have been seen. In addition to whole body bone scan scintigraphy applied initially, control scintigraphy was thought to help to evaluate the effectiveness of radionuclide pain palliation theraphy.