Oral presentations at scientific meetings: some hints and tips

Katchburian, E.

doi:10.1590/s1516-31802003000100010

Cited by 2 publications

(4 citation statements)

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“…The administration of fluoxetine in pregnant rats can alter the levels of available serotonin, making it possible to study its influence on tooth development, which, in turn, results from important epithelial-mesenchymal interactions3. In this study, the administration of fluoxetine at 10 mg/kg showed no morphological changes in the enamel organ in the first molars that could impair the development of amelogenesis.…”

Section: Discussionmentioning

confidence: 59%

“…From the 17th day i.u.l., we observed germ tissue at the hood, with regions of the enamel organ bounded in both groups with the same structural characteristics. As the development of the tooth germ typically occurs until the stage of the crown or bell, the development advanced in animals at one, five and ten days postpartum, with appropriate characteristics for each stage of odontogenesis 2,3…”

Section: Discussionmentioning

confidence: 99%

“…The tooth germ developed all elements of the future tooth crown; histodifferentiation occurred, thereby allowing cells to secrete the dental tissues, especially the enamel 19,20. During differentiation of internal epithelium to ameloblastic cells, the cells in the concavity of the enamel organ retained the same structural characteristics, indicating that the synthesis and maturation of the enamel occurred normally 2,3…”

Section: Discussionmentioning

confidence: 99%

“…The enamel organ is the portion of the germ dental epithelium composed of the external epithelium, internal epithelium, the reticulum star, and the intermediate stratum. From the enamel organ emerges tooth enamel, the organic matrix of which is deposited by ameloblastic cells through a process called amelogenesis 1–3. One hypothesis suggests that one function of neurotransmitters during development results from their early presence during the stages of embryogenesis-regulating events, such as during the first cell division after fertilization, gametogenesis, morphogenesis, migration, and cell differentiation in different tissues 4,5.…”

Section: Introductionmentioning

confidence: 99%

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Morphological Analysis of the Enamel Organ in Rats Treated with Fluoxetine

Silva

Leão

Evêncio

et al. 2010

Clinics

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PURPOSE:Previous studies have evaluated the presence of serotonin in the dental epithelia and mesenchyme during odontogenesis, suggesting its participation in tooth development.MATERIALS AND METHODS:Here, we used fluoxetine, a selective serotonin re-uptake inhibitor, at a dose of 10 mg/kg, administered for 20 days during pregnancy in 12 Wistar rats to examine the influence of this drug on the development of the enamel organ of the upper first molars of rat fetuses at 17 days of intra-uterine life (i.u.l.), and at one, five and ten days postpartum. The pregnant rats were anesthetized with xylazine at 10 mg/kg and ketamine at 25 mg/kg. The fetuses were removed and beheaded; their jaws were removed, and the upper jaws were exposed. The tissues were fixed in Bouin’s fixative, decalcified in 5% nitric acid for 4 – 12 h, conventionally processed for microscopy, and embedded in paraffin. Serial sections of approximately 5 μm were obtained and stained with hematoxylin and eosin, as well as periodic acid-Schiff.RESULTS AND CONCLUSION:Morphological analysis showed no structural changes in the experimental group compared to the controls, suggesting that, at the dose used, fluoxetine does not interfere with serotonin-mediated development of the enamel organ or the process of amelogenesis.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%