Incidental and symptomatic renal tumors: impact on patient survival

Dall’Oglio, Marcos F.; Srougi, Miguel; Gonçalves, Pierre D.; Leite, Kátia Ramos Moreira; Nesrallah, Luciano J.; Hering, Flávio

doi:10.1590/s1516-31802002000600002

Cited by 10 publications

(7 citation statements)

References 40 publications

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“…The 5-year CSS of 94% for group 1 and 82.5% for group 2 in the present study are comparable with the 5-year survival rate of 83–95% for incidental tumours and 30–83% for symptomatic renal tumours reported previously [2]. The diagnosis of incidental renal tumours was reported by Dall’Oglio [10] to have a better prognosis and longer disease-free survival. In their study of 115 patients, Dall’Oglio [10] found that 59 (51%) patients had an incidental diagnosis and 56 (49%) were symptomatic.…”

Section: Discussionsupporting

confidence: 89%

“…The diagnosis of incidental renal tumours was reported by Dall’Oglio [10] to have a better prognosis and longer disease-free survival. In their study of 115 patients, Dall’Oglio [10] found that 59 (51%) patients had an incidental diagnosis and 56 (49%) were symptomatic. In the incidental group only one patient had tumour progression and there were no deaths, while in the symptomatic group there were five progressions and 10 deaths.…”

Section: Discussionmentioning

confidence: 97%

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Incidental vs symptomatic renal tumours: Survival outcomes

Al-Marhoon

Osman

Kamal

et al. 2011

Arab Journal of Urology

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PurposeCurrently there is an increase in the incidental diagnosis of renal cell carcinoma (RCC). Our aim was to assess the survival of patients with incidental and symptomatic renal tumours who had undergone nephrectomy.Patients and methodsWe retrospectively assessed 604 patients who underwent renal surgery for RCC between 1983 and 2005. Patients were divided in two groups; group 1 had incidental and group 2 had symptomatic tumours. The median follow-up was 4 and 3.3 years for groups 1 and 2, respectively. All patients had surgery in the form of radical or partial nephrectomy. Sex, age, tumour size, type of surgery, pathological characteristics and patient survival in both groups were evaluated. The statistical analysis included the log-rank, Kaplan–Meier and Cox regression tests.ResultsThere were 85 patients (14%) in group 1 (mean age 49.6 years) and 519 (86%) in group 2 (mean age 50 years). The mean (SEM, range) tumour size was 7.4 (0.4, 1.5–20) cm in group 1 and 9.7 (0.2, 2–38) cm in group 2 (P < 0.001). The most common stage was T1 (52%) and T2 (44%) in groups 1 and 2, respectively, with a predominance of G2 grade and the conventional type histology in both the groups. There was a significant difference in cancer-specific survival (CSS) between the groups (log-rank, P = 0.017). The 5- and 10-year CSS was 94% and 94% for group 1, and 82.5% and 79.5% for group 2. Cox regression analysis showed that in group 1, only the tumour mid-zonal location (P = 0.093), tumour stage pT (P < 0.001), grade 1 (P = 0.03), grade 2 (P = 0.01), grade 4 (P = 0.01) and the papillary histological type (P = 0.019) had significant effects on CSS. In group 2, only tumour size (P = 0.022) and stage pN (P = 0.003) had significant effects on CSS. The tumour recurrence rate was 18% and 29% for groups 1 and 2, respectively.ConclusionsThis large study supports the findings of other smaller studies published previously, confirming that at presentation incidental renal tumours are smaller and their diagnosis provides a better prognosis and longer CSS.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 97%

Incidental vs symptomatic renal tumours: Survival outcomes

Al-Marhoon

Osman

Kamal

et al. 2011

Arab Journal of Urology

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“…Some interesting information about the epidemiology of cancer may be obtained from unselected autopsy material. Although anatomopathological autopsies are most frequently analyzed [4], it is difficult to regard them as entirely unselected; this is the why we decided to analyze forensic autopsies [7,[14][15][16][17][18][19][20]. Renal tumors are highly heterogeneous.…”

Section: Discussionmentioning

confidence: 99%

Renal tumors in unselected forensic post-mortem material

Rzepecka-Woźniak¹,

Trzepla²,

Okoń³

2014

pjp

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The frequency of clinically evident renal tumors is increasing, due to an actual increase in incidence, but also due to an improvement in detection methods. The aim of the present study was to analyze the incidence of renal tumors in an unselected autopsy series. A search for renal tumors was conducted based on the autopsy reports from the Department of Forensic Medicine. The slides were reviewed and reclassified according to current criteria. Among 14,904 autopsies, 80 renal tumors were found. The most frequent tumor types were clear cell carcinomas (41%), papillary carcinomas (18%) and cortical adenomas (19%). There were 66 males and 14 females. The average age was 57.83 for males and 62.86 for females. The characteristics of the study group were not exactly identical but similar to other autopsy series, and significantly different from surgical series.

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“…observed in Uruguay and in the south of Brazil (Porto Alegre 10.2 per 100.000 men) (6), contrasting with low rates in the north of Brazil and in the middle-west area, Goiania for instance (7,8).…”

Section: Epidemiologymentioning

confidence: 99%

“…The introduction of radical nephrectomy as the standard of care, together with earlier diagnosis provided by an increased frequency of radiological imaging, has made some progress in RCC managebetter global survival (7). (Figure-1) …”

Section: Treatment the Trial Search Strategymentioning

confidence: 99%

Localized renal cell carcinoma management: an update

et al. 2008

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Objective: To review the current modalities of treatment for localized renal cell carcinoma. Materials and Methods: A literature search for keywords: renal cell carcinoma, radical nephrectomy, nephron sparing surgery, minimally invasive surgery, and cryoablation was performed for the years 2000 through 2008. The most relevant publications were examined. Results: New epidemiologic data and current treatment of renal cancer were covered. Concerning the treatment of clinically localized disease, the literature supports the standardization of partial nephrectomy and laparoscopic approaches as therapeutic options with better functional results and oncologic success comparable to standard radical resection. Promising initial results are now available for minimally invasive therapies, such as cryotherapy and radiofrequency ablation. Active surveillance has been reported with acceptable results, including for those who are poor surgical candidates. Conclusions: This review covers current advances in radical and conservative treatments of localized kidney cancer. The current status of nephron-sparing surgery, ablative therapies, and active surveillance based on natural history has resulted in great progress in the management of localized renal cell carcinoma.

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Incidental and symptomatic renal tumors: impact on patient survival

Cited by 10 publications

References 40 publications

Incidental vs symptomatic renal tumours: Survival outcomes

Incidental vs symptomatic renal tumours: Survival outcomes

Renal tumors in unselected forensic post-mortem material

Localized renal cell carcinoma management: an update

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