Squamous cell carcinoma of the gallbladder

Waisberg, Jaques; Bromberg, Sansom Henrique; Franco, Maria Isete Fares; Yamagushi, Nagamassa; Santos, Paulo Amaral dos; Castro, M.

doi:10.1590/s1516-31802001000100010

Cited by 20 publications

(31 citation statements)

References 3 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The clinical presentation of adenosquamous carcinoma/squamous cell carcinoma group in this study did not seem to be too different than ordinary gallbladder adenocarcinomas, and the impression in the literature is in accordance with this observation. 9,[13][14][15]21,23,25,29 The patients are in their mid 60s-the youngest patient in this study was 26-and it occurs predominantly in females (F/M ¼ 3.8), similar to gallbladder adenocarcinomas (F/ M ¼ 3.8). As is the case for most gallbladder carcinomas, preoperatively, most patients (485%) are not suspected to have cancer, and instead undergo cholecystectomy with the diagnosis of cholecystitis.…”

Section: Discussionmentioning

confidence: 99%

“…1,7,8 The literature on these histologic types has been highly limited, mostly represented as individual case reports or analysis of small case series of a handful of cases. [9][10][11][12][13][14][15][16][17][18][19][20] Furthermore, there has been no uniform definition for these tumors, with different authors employing different criteria: some regarded any squamous differentiation as a qualification for adenosquamous carcinoma even if it is a very small component of the tumor, and at the same time, others seemed to have included cases with substantial adenocarcinoma component into squamous cell carcinoma category. 9,13,14,[21][22][23] These definitional differences may partly be responsible for the variations in reported incidence of these tumors, which ranges from 1 to 12%.…”

mentioning

confidence: 99%

“…14,18,[24][25][26][27][28] Although the limited nature of the data and the definitional variations precluded proper characterization of these tumors, some common threads could be observed: it had been speculated that adenosquamous carcinomas/ squamous cell carcinomas are at least as aggressive as ordinary gallbladder adenocarcinomas. 9,11,[13][14][15]23,29 It has been observed that the squamous component of gallbladder carcinomas proliferates at a higher rate than the glandular component; 14 however, despite their high proliferation rate, these tumors appeared to less frequently present with lymph node metastasis than gallbladder adenocarcinomas. 21 Their aggressive biological behavior has been attributed to their potential for direct extension and early invasion into the liver and neighboring organs, such as the stomach, duodenum and transverse colon.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Gallbladder Squamous Cell Carcinoma with Chronic Right Upper Quadrant Discomfort

Park¹,

Lee²,

Hong³

et al. 2018

Clin Ultrasound

View full text Add to dashboard Cite

The information in the literature on squamous cell and adenosquamous carcinomas of the gallbladder is highly limited. In this study, 606 resected invasive gallbladder carcinoma cases were analyzed. Squamous differentiation was identified in 41 cases (7%). Those without any identifiable glandular-type invasive component were classified as pure squamous cell carcinomas (8 cases) and those with the squamous component constituting 25-99% of the tumors were classified as adenosquamous carcinomas (26 cases) and included into the analysis. The remaining 7 that had o25% squamous component were classified as adenocarcinoma with focal squamous change and excluded. The clinicopathological characteristics of adenosquamous carcinoma/squamous cell carcinomas were documented and contrasted with that of ordinary gallbladder adenocarcinomas. The average patient age was 65 years (range 26-81); female/male ratio, 3.8. In only 13%, there was a preoperative clinical suspicion of malignancy. Grossly, 58% presented as thickening and hardening of the wall and 6% were polypoid. In 12%, mucosa adjacent to the tumor revealed squamous metaplasia. All pure squamous cell carcinomas had prominent keratinization. Giant cells and tumor-infiltrating eosinophils were observed in 29 and 51% of the squamous cell carcinomas/adenosquamous carcinomas versus 10% (P ¼ 0.02) and 6% (P ¼ 0.001) in gallbladder adenocarcinomas, respectively. All but three cases had 'advanced' (pT2 and above) carcinomas. Follow-up was available in 31 patients: 25 died of disease (median ¼ 5 months, range 0-20), and 6 were alive (median ¼ 64 months, range 5-112.5). The survival of patients with squamous cell carcinomas/adenosquamous carcinomas was significantly worse than that of gallbladder adenocarcinomas (P ¼ 0.003), and this adverse prognosis persisted when compared with stage-matched advanced gallbladder adenocarcinoma cases (median ¼ 11.4 months, P ¼ 0.01). In conclusion, squamous differentiation was noted in 7% of gallbladder carcinomas. The incidence of adenosquamous carcinoma (defined as 25-99% of the tumor being squamous) was 4%, and that of pure squamous cell carcinoma (without any documented invasive glandular component) was 1%. Pure squamous cell carcinomas often showed prominent keratinization. The overall prognosis of adenosquamous carcinoma/squamous cell carcinoma appears to be even worse than that of ordinary adenocarcinomas. Most patients died within a few months; however, those few who were alive beyond 2 years in this cohort experienced long-term survival.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Gallbladder Squamous Cell Carcinoma with Chronic Right Upper Quadrant Discomfort

Park¹,

Lee²,

Hong³

et al. 2018

Clin Ultrasound

View full text Add to dashboard Cite

show abstract

“…Squamous-cell carcinoma of the gallbladder is most often diagnosed at an advanced stage and is considered more aggressive and of worse prognosis than adenocarcinoma. This rare case of cancer is known to metastasize to unusual sites such as skin and subcutaneous tissues [2][3][4]. Some publications reported that squamous-cell carcinoma may be less often associated with nodes metastasis but this point is discussed in the literature [4].…”

Section: Introductionmentioning

confidence: 99%

“…None prospective study has been conducted in patients with squamous-cell carcinoma of gallbladder and data reported in the literature are limited. Only few therapeutic data have been reported from cases report or small series [1,2,7,9,11,15,16].…”

Section: Introductionmentioning

confidence: 99%

Squamous-Cell Gallbladder Carcinoma: How to Treat?

Verlicchi¹,

Hannoun²,

Bachet³

2015

J Cell Sci Ther

View full text Add to dashboard Cite

Squamous-cell gallbladder carcinoma is a very rare cancer with very few therapeutic data available in the literature. We describe a case of this rare disease with a good response under Gemcitabine and Cisplatin after several previous lines of chemotherapy, in an 80-year-old man. In our case, the disease was resistant to FOLFOX, FOLFIRI and Paclitaxel but an impressive partial response was shown after 9 cycles of Gemcitabine and Cisplatin in fourth-line of chemotherapy. Unfortunately, a progression occurred after 12 cycles (7 months). With the intent of finding a new therapeutic option a molecular analysis was performed using Next-Generation Sequencing and two mutations of ERBB2 and PTEN were found. A standard regimen of chemotherapy for squamous-cell gallbladder cancer does not exist and, because of the rarity of this type of cancer, therapeutic trials will probably never be conducted. The end point of this works is to describe this interesting case and make a review of the literature about treatments used for squamous-cell carcinoma of the gallbladder.

show abstract

Variants of Gallbladder Carcinoma

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

View full text Add to dashboard Cite

Squamous cell carcinoma of the gallbladder

Cited by 20 publications

References 3 publications

Gallbladder Squamous Cell Carcinoma with Chronic Right Upper Quadrant Discomfort

Gallbladder Squamous Cell Carcinoma with Chronic Right Upper Quadrant Discomfort

Squamous-Cell Gallbladder Carcinoma: How to Treat?

Variants of Gallbladder Carcinoma

Contact Info

Product

Resources

About