Effect of hormone replacement therapy on the bone mass and urinary excretion of pyridinium cross-links

Abstract

Urinary pyridinoline and deoxypyridinoline excretion decreases early in hormone replacement therapy, reflecting a decrease in the bone resorption rate, and no correlation was observed with the bone mass evaluated by densitometry.

Effect of three months of periodized hydrogymnastics exercise program on urinary concentration of deoxypyridinoline in older women

“…Regarding the assessment of osteoporosis in elderly population urinary concentration of deoxypyridinoline was chosen for inexpensive, validated, easy to apply bone marker which have been identified as a good prediction by early change of bone metabolic markers of the efficacy of anti-osteoporotic drugs on bone mass in osteoporotic patients (13)(14)(15)(16). Strength exercise modalities have been showed better results in in biochemical markers of bone turnover (17,19,28) due the voluntary muscle contraction produces stress on bone morphology and the mechanical load resulting from the muscle contraction induced osteoblast formation and inhibits bone resorption (9) instead of aquatic exercises where the reduction of the gravity forces on human body when immersed in water makes and low high impact seem to be less osteogenic (29).…”

“…The deoxypyridinoline has been identified as a good prediction by early change of bone metabolic markers of the efficacy of anti-osteoporotic drugs on bone mass in osteoporotic patients (13)(14)(15)(16).…”