CEA as a prognostic index in colorectal cancer

Forones, Nora Manoukian; Tanaka, M; Falcão, Jeane Brito

doi:10.1590/s1516-31801997000600006

Cited by 44 publications

(44 citation statements)

References 11 publications

(2 reference statements)

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“…Despite the controversy concerning the validity of measuring the pre-operative levels of CEA, our studies emphasize their value and demonstrate an association between higher levels of CEA and poorer prognosis (12,42) . Some research contradicts these findings and show that 14% to 56% of CRC cases can present with normal blood levels of CEA (44,47) .…”

Section: Discussionmentioning

confidence: 57%

“…The results obtained in the present study support a correlation between the Dukes (9) , TNM (18) and morphofunctional classifications and increased CEA levels in advanced stages of neoplasia. These results demonstrate a rise in CEA levels in the blood, which is associated with disease progression, although, current studies relating CEA and prognostic classification are controversial (5,12,44) . An increase in CEA levels after complete resection can suggest cancer recurrence (8) , but there is a subset of CRC tumors that produce a small quantity of CEA and blood levels remain normal.…”

Section: Discussionmentioning

confidence: 82%

“…Studies have analyzed the prognostic power of plasma CEA levels and how it relates to morphologic features at different stages. The data generated from these studies suggests a relationship between plasma CEA levels and poor prognosis; however, there are contradicting results (12,14,44) . After resection of neoplastic lesions, CEA levels may increase and this suggests neoplastic relapse (5) , however, there are tumors that produce only small amounts of CEA.…”

Section: Introductionmentioning

confidence: 95%

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Morphofunctional malignancy grading is a valuable prognostic factor for colorectal cancer

Priolli

Piovesan

Cardinalli

et al. 2010

Arq. Gastroenterol.

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-Context -Novel strategies are needed to identify more efficient biomarkers to accurately diagnose prognose and improve the treatment outcome of colorectal cancer. Objectives -To analyze the functional and morphological features of colorectal cancer to identify the neoplastic patterns that affect patient survival. Methods -Forty-five patients with colorectal cancer were followed for a minimum of 3 years. Blood levels of carcinoembryonic antigen (CEA) were measured by chemiluminescence and immunohistochemical analysis of tissue expression followed by computer-assisted image processing. Tumors were assigned to three morphofunctional classes. The morphofunctional classification was based on combination between histological differentiation and cell polarization. The functional characterization was based on the CEA cell polarization. The tissue polarization of CEA was classified in well-polarized, moderately polarized or nonpolarized cells. Morphofunctional staging was defined by the association between morphofunctional class (polarization and histological differentiation) and TNM by score given to each one classification. Results -There was an association between increased CEA tissue expression and loss of histological differentiation (P = 0.01) or loss of polarization capacity (P = 0.03). There was a progressive increase in tissue CEA quantities in accordance with the proposed morphofunctional grading system. Plasma levels of CEA were increased in advanced tumor stages. Blood levels of CEA were increased in advanced morphofunctional stages (P = 0.001). There was a relationship between survival outcome and morphofunctional staging (P = 0.005). Conclusion -Morphofunctional staging is a valuable prognostic factor for colorectal cancer and it correlates with plasma CEA levels.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 95%

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Morphofunctional malignancy grading is a valuable prognostic factor for colorectal cancer

Priolli

Piovesan

Cardinalli

et al. 2010

Arq. Gastroenterol.

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“…Forones et al 14 retrospectively studied peripheral CEA levels in 83 patients with regard to prognoses for colorectal cancer and correlated these with the Dukes staging. They found that CEA had a capacity to differentiate stage A from stage C and C from B, but not A from B.…”

Section: Discussionmentioning

confidence: 99%

Relationship between peripheral and mesenteric serum levels of CEA and CA 242 with staging and histopathological variables in colorectal adenocarcinoma

et al. 2009

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Purpose:To compare histopathological variables and staging in colorectal adenocarcinoma cases with CEA and CA 242 in peripheral and mesenteric blood. Methods: In 169 individuals underwent surgery for colorectal cancer, CEA and CA 242 were analyzed and compared to mesenteric and peripheral blood and correlated with macroscopic tumor's morphology and size, degree of cell differentiation, venous, neural and lymphatic involvement and TNM classification. Results: There was a difference between the mesenteric (M) and peripheral (P) serum levels of CEA (p=0.020). Higher levels of markers were correlated with venous invasion CEA (P) p=0.013, CEA (M) p=0.05, CA 242 (M) p=0.005 and CA 242 (P) p=0.038; with advanced staging CEA (P) < CEA (M) (p < 0.05); CA 242 (P) < CA 242 (M) (p < 0.05); and with greater dimensions CEA (P) < CEA (M) (p < 0.001); CA 242 (P) < CA 242 (M) (p < 0.001). CA 242 became higher with neural invasion (P): p=0.014, (M): p=0.003). Conclusions: There were higher mesenteric than peripheral levels of CEA. Both mesenteric and peripheral levels of CEA and CA 242 were higher in neoplasm with venous involvement, greater diameter and advanced stages. There was a correlation between CA 242 and neural invasion. Key words: Adenocarcinoma. Prognosis. Tumor Markers, Biological. Colon. Rectum. RESUMO Objetivo:Comparar variáveis histopatológicas e graus de estadiamento do adenocarcinoma colorretal com níveis sanguíneos periféricos e mesentéricos de CEA e CA-242. Métodos: Em 169 doentes submetidos ao tratamento cirúrgico por adenocarcinoma colorretal, CEA e CA-242 foram analisados e comparados quanto aos níveis sanguíneos periféricos e mesentéricos e correlacionados com o tamanho e a morfologia macroscópica do tumor, grau de diferenciação celular, invasões venosa, linfática, neural e a classificação TNM. Resultados: Verificou-se diferença significante entre o nível sérico mesentérico e periférico de CEA (p= 0,02). Níveis séricos mais elevados dos marcadores foram observados e correlacionados com invasão venosa, CEA (P) p=0,013, CEA(M), p=0,05, CA-242 (M) p=0,005 e CA-242 (P) p=0,038. Grau de estadiamento TNM avançado foi associado com CEA(P) < CEA(M) p<0,05, CA-242(P) < CA-242(M) p<0,05. Nas maiores dimensões tumorais constatou-se CEA(P) < CEA(M) p=0,001 e CA 242 (P) < CA 242 (M) (p < 0.001). O CA 242 periférico e mesentérico aumentados associaram-se com a invasão neural, p=0.014 e p=0.003, respectivamente. Conclusões: O nível sérico mesentérico de CEA é superior ao nível sérico periférico. Os níveis séricos mesentéricos e periféricos do CEA e do CA-242 são mais elevados no adenocarcinoma com invasão venosa, de maior diâmetro e de estadios avançados. Existe uma associação entre o nível sérico do Ca-242 e a invasão neural. Descritores: Adenocarcinoma. Prognóstico. Marcadores Biológicos de Tumor. Colo. Reto.

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“…24,27 Contradizem estes achados pesquisas mostrando que 14% a 56% dos casos de CCR podem cursar com nível sérico de CEA normal. 23,44 A correlação dos níveis séricos do CEA pré-operatórios com o está-dio do carcinoma colorretal permanece polêmica.…”

Section: Estadiamentounclassified

Proposta para estadiamento do câncer colorretal baseada em critérios morfofuncionais: correlação com níveis séricos do antígeno carcinoembrionário

Priolli

Cardinalli

Piovesan

et al. 2007

Rev bras. colo-proctol.

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CEA as a prognostic index in colorectal cancer

Abstract: Although the tumor stage is today the most valuable prognostic variable in colorectal cancer, the preoperative CEA value can provide some additional information in the prognosis of the patient.

Cited by 44 publications

References 11 publications

Morphofunctional malignancy grading is a valuable prognostic factor for colorectal cancer

Morphofunctional malignancy grading is a valuable prognostic factor for colorectal cancer

Relationship between peripheral and mesenteric serum levels of CEA and CA 242 with staging and histopathological variables in colorectal adenocarcinoma

Proposta para estadiamento do câncer colorretal baseada em critérios morfofuncionais: correlação com níveis séricos do antígeno carcinoembrionário

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