Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy

Abstract

Introduction:An inhibitory serum factor of mixed Iymphocyte culture (MLC) has been associated with successful pregnancy after. Iymphocyte transfusion in women with unexplained recurrent spontaneous abortions (ASA). Objective:Investigate whether the inhibitory serum factor of MLC is essential for a successful pregnancy. Method: Sera from 33 healthy pregnant women and from 40 women with ASA were assessed by a one-way MLC in which the woman's Iymphocytes were stimulated with her partner's Iymphocytes or with third.party Iymphocytes. Results: An inhibitory serum effect (inhibition > 50% as compared to normal serum) was detected in 45% of the pregnant women who had at least 1 previous parity, in 80/0 of the primigravidea, in 29% of those with one abortion and in 58% of those with more than one abortion. Conclusion: ,MLC inhibitory serum factor does not seem to be an essential factor for pregnancy development. Therefore, it should not be considered as a parameter for the assessment of ASA patients.