Importance of peniscopy, oncologic cytology and histopathology in the diagnosis of penile infection by human papillomavirus

Nicolau, Sérgio Mancini; Martins, Nelson Valente; Ferraz, Paulo Eduardo; Stávale, João Norberto; Gonçalves, Wagner José; Baracat, Edmund Chada; Lima, Geraldo Rodrigues de

doi:10.1590/s1516-31801997000100003

Cited by 10 publications

(14 citation statements)

References 14 publications

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“…Koilocytosis was the most frequent histological finding (27.8%) in the men who were positive for HPV DNA ( Table 2). Hippeläinen et al (24) found that 53.7% of a group of HPV DNA-positive men exhibited koilocytosis, while Nicolau et al (26) using the same methodology, found a 50% frequency of koilocytosis. The results of our study did not allow us to infer that koilocytosis is a pathognomonic characteristic of HPV infection of the male urinogenital area because there were as many false-positives as false-negatives, a fact which may lead to false information being given to the patient.…”

Section: Discussionmentioning

confidence: 99%

<a name="home"></a>Infection with human papillomaviruses of sexual partners of women having cervical intraepithelial neoplasia

Rombaldi

Serafini

Villa³

et al. 2006

Braz J Med Biol Res

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Epidemiological studies show that human papillomaviruses (HPV) are strongly related to cervical cancer and cervical intraepithelial neoplasias (CIN). Unlike the case for women, there are no consistent data on the natural history of HPV in the male population even though these viruses are prevalent in males. We carried out a prospective study to assess the prevalence of HPV in males as well as the factors that determine such infections in 99 male sexual partners of women with CIN. The genitalia of the males were physically examined and subjected to peniscopy for the collection of scrapings which were subjected to the polymerase chain reaction and restriction fragment length polymorphism to detect HPV. Of the 99 males sampled, 54 (54.5%) were positive for HPV DNA, 24% of whom presented normal peniscopy, 28% presented evident clinical lesions and 48% isolated lesions consistent with subclinical infection. In the HPV-negative group, 53% showed normal peniscopy, 4% presented evident clinical lesions and 42% isolated lesions consistent with subclinical infection. The study detected a statistically significant association (P < 0.02, Pearson chi-square test) between HPV infection and both the mean number of sexual partners which a male had during his life and the mean number of sexual partners in the year prior to testing. Viral types 6 and 11 were most frequently encountered. The study shows that infection with HPV was frequent in male sexual partners of women with CIN.

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Section: Discussionmentioning

confidence: 99%

<a name="home"></a>Infection with human papillomaviruses of sexual partners of women having cervical intraepithelial neoplasia

Rombaldi

Serafini

Villa³

et al. 2006

Braz J Med Biol Res

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Section: Discussionmentioning

confidence: 99%

“…There have been few cytological studies of male HPV infection because of its poor diagnostic capacity . Nicolau reported that cytological examination revealed koilocytosis, which was the most common morphological change associated with HPV infection, in only 4.7% of urethra samples and 1.6% of samples of the corona of the glans among 190 male sex partners of women with genital infection by human papillomavirus . In another study, koilocytosis was detected in only one of 93 HPV‐positive penile samples collected from 58 men with condyloma acuminata or 41 male sexual partners of women with a diagnosis of cervical HPV infection, by a liquid‐based cytological procedure .…”

Section: Discussionmentioning

confidence: 99%

Cytological evaluation using liquid‐based cytology in the male urogenital tract infected with human papillomavirus

Shigehara

Sasagawa

Kawaguchi

et al. 2013

Diagnostic Cytopathology

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This study was performed to determine the associations between human papillomavirus (HPV) infection and cytological changes in the male glans and urethral samples. Two rubbed samples of the glans and distal urethra were collected from 160 patients with urethritis, and the collected cells were placed into preservative solution for liquid-based cytology. DNA was extracted from all samples, and β-globin gene amplification, HPV-DNA test, and HPV genotyping were performed. After papanicolaou staining of each sample, cytological findings were assessed based on nine non-classic signs, and compared with the results of HPV-DNA test. Among the β-globin positive samples, HPV (any type) was detected in 33 and 25% of the glans and urethra samples, respectively. High-risk HPV-DNA was detected in 25 and 15% of the glans and urethra samples, respectively. In the glans samples, cytological signs of HPV infection were observed in 17% of low-risk HPV-positive samples and in 58% of high-risk HPV-positive samples. Cytological atypia suspected to indicate penile intraepithelial neoplasia were observed in 17 and 33%, respectively. On the other hand, abnormal cells were observed in 29% of low-risk HPV-positive and 83% of high-risk HPV-positive urethral samples. Cytological atypia suspected to be urethral intraepithelial neoplasia was observed in 29 and 65%, respectively. In situ hybridization demonstrated the presence of HPV-DNA in the morphologically abnormal cells in 31 and 35% of high-risk HPV-positive glans and urethral samples, respectively. Cytological changes similar to cervical intraepithelial neoplasia in females could be detected in the HPV-positive glans and urethral samples.

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“…The histological assessment is essential (especially in elderly patients) to exclude invasion of the basement membrane, which dictates the mode of management and follow-up 33 .…”

Section: Investigationsmentioning

confidence: 99%

The management of penile intraepithelial neoplasia in genitourinary medicine

Markos

2003

Int J STD AIDS

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The incidence of reporting of penile intraepithelial neoplasia (PIN) by genitourinary medicine clinics in the UK is rare. The reporting of higher incidence, in most international studies, is suggestive of under-diagnosis of PIN lesions in the UK, which leads to improper therapy and follow-up. A systematic literature review is undertaken, regarding the current state of management of PIN and the possible avenues of improvement in the diagnosis and follow-up. The role of genitourinary medicine clinics is examined, in view of the high number of patients that present with genital dermatological conditions, in whom there are patients with non-identified PIN lesions. The notable increase in reporting of vulval intraepithelial neoplasia has been associated with an increase in vulval cancer, especially in younger patients. The possibility of a similar trend in penile lesions needs to be observed and the association between high risk human papillomavirus (HPV) types, and genital intraepithelial neoplasia and cancer, is recognized and therefore an increased incidence in the diagnosis of HPV associated lesions must be considered.

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Importance of peniscopy, oncologic cytology and histopathology in the diagnosis of penile infection by human papillomavirus

Cited by 10 publications

References 14 publications

<a name="home"></a>Infection with human papillomaviruses of sexual partners of women having cervical intraepithelial neoplasia

<a name="home"></a>Infection with human papillomaviruses of sexual partners of women having cervical intraepithelial neoplasia

Cytological evaluation using liquid‐based cytology in the male urogenital tract infected with human papillomavirus

The management of penile intraepithelial neoplasia in genitourinary medicine

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