Current concepts on the transmission of bacteria and parasites by blood components

Neto, Silvano Wendel

doi:10.1590/s1516-31801995000600007

Cited by 10 publications

(4 citation statements)

References 66 publications

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“…pallidum ssp. pallidum überlebt außerdem für einige Wochen im tiefgefrorenen Plasma [15]. Weiterhin wurde in mehreren klinischen und tierexperimentellen Arbeiten angegeben, dass die Bakterien in Citratblut bei 4°C zwischen 24 und 120 Stunden infektiös blieben [16,17,18].…”

Section: Erregereigenschaftenunclassified

See 1 more Smart Citation

Bekanntmachung des Arbeitskreises Blut des Bundesministeriums für Gesundheit¶Treponema pallidum

Available¹

2002

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschu

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Section: Erregereigenschaftenunclassified

“…), sind weitere Argumente für die geringe Wahrscheinlichkeit solcher Ereignisse. Infektionen durch das Blut seronegativer Spender in der Inkubationszeit, welche später Antikörper entwickelten, sind jedoch in Einzelfällen beschrieben worden [15,21,47].…”

Section: Bundesgesundheitsbl -Gesundheitsforsch -Gesundheitsschutz 10unclassified

Bekanntmachung des Arbeitskreises Blut des Bundesministeriums für Gesundheit¶Treponema pallidum

Available¹

2002

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschu

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“…Prevention strategies of TTPIs are different in endemic and non‐endemic areas . There are multiple strategies to prevent the transmission of parasitic agents via blood transfusion, including donor selection and deferral (permanent or temporary), testing of blood donation and the use of leukoreduction filters and pathogen inactivation techniques . In Europe, the United States of America (USA) and many countries, the main strategy for preventing TTPIs is donor selection by interviewing .…”

Section: Introductionmentioning

confidence: 99%

Prevention strategies of transfusion‐transmitted parasitic infections (TTPIs) in Iran, an endemic area for malaria, toxoplasmosis and leishmaniasis

Mardani

2019

ISBT Science Series

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Background and Objectives Parasitic infections are one of the most important adverse reactions of blood transfusion. Several strategies are being implemented in blood transfusion centers of the world to prevent the transfusion-transmitted parasitic infections (TTPIs). The objective of this work was to clarify and describe the strategies to minimize the transmission risk of endemic parasitic agents in Iran via blood transfusion. Materials and MethodsThis study was conducted in the Iranian blood transfusion organization (IBTO). The data were extracted from the latest version of the "medical interview" standard operating procedure (SOP) and then recorded in the prepared sheets. ResultsThe donor selection is the first and only step to reduce the risk of TTPIs in endemic and non-endemic areas of Iran. In all blood transfusion centers of the IBTO, the blood donation volunteers with a previous history of malaria, Chagas disease, visceral leishmaniasis (VL), muco-cutaneous leishmaniasis and babesiosis, as well as those with toxoplasmosis, cutaneous leishmaniasis (CL) and with a history of residence in, or travel to, malaria-endemic areas are permanently or temporarily deferred from the blood donation. ConclusionFor some reasons, including the prevalence of malaria, toxoplasmosis and VL in parts of Iran, the donor selection strategy is not sufficient to prevent the TTPIs. Therefore, the changing of donor selection process and the use of other common preventive strategies are recommended to reduce the risk of TTPIs, especially for high-risk groups of toxoplasmosis and VL.

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“…Another risk group consists of patients with aplastic anemia, sickle cell anemia, thalassemia, and lymphoproliferative disorders who receive blood transfusion regularly or frequently for survival. The transfusion of infected blood in these patients due to their immunodeficiency disorders would cause serious disease (13,14). Toxoplasma gondii is one of the intracellular microorganisms that can stay alive for up to 50 days in the citrated blood and the buffy coat at 5°C (15).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Toxoplasma gondii Infection in Healthy Volunteer Blood Donors Using Serological and Molecular Methods from Chaharmahal and Bakhtiari Province, Southwest Iran

Naeini

Soureshjani

Jafari

et al. 2019

Jundishapur J Microbiol

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Background: Toxoplasmosis is a ubiquitous zoonotic disease caused by Toxoplasma gondii. Blood and blood products can be a probable route of T. gondii transmission, especially in patients undergoing multiple transfusions. Objectives: The aim of this cross-sectional study was to determine the prevalence of T. gondii infection among healthy blood donors in Chaharmahal and Bakhtiari province. Methods: We collected 385 blood samples from blood donors referring to the three biggest Blood Transfusion Organization Centers in the province during the period from January to June 2017. IgG and IgM antibodies against T. gondii were examined using enzymelinked immunosorbent assay. Moreover, all samples were tested by loop-mediated isothermal amplification (LAMP) method for the detection of DNA of T. gondii. Results: The seroprevalence rates of IgG and IgM anti-T. gondii antibodies were 37.9% and 1.56%, respectively. With the LAMP method, 1.56% of the samples were positive for the DNA of T. gondii. Of these, four (1.04%) were seropositive for both IgG and IgM and two (0.52%) were positive only for IgG. Moreover, statistical analyses indicated that several risk factors including gender, age, contact with cats, and consumption of undercooked meat were significantly related to T. gondii seropositivity in blood donors. Conclusions: This study indicated that anti-T. gondii antibodies were highly prevalent among apparently healthy blood donors in Southwest Iran. There was a possibility of infection transmission by blood transfusion while there is a lack of screening tests for Toxoplasma infection in the Blood Transfusion Organizations. It is strongly suggested that appropriate and sensitive screening programs be designed by the LAMP method for the detection of T. gondii in blood donors.

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Current concepts on the transmission of bacteria and parasites by blood components

Cited by 10 publications

References 66 publications

Bekanntmachung des Arbeitskreises Blut des Bundesministeriums für Gesundheit¶Treponema pallidum

Bekanntmachung des Arbeitskreises Blut des Bundesministeriums für Gesundheit¶Treponema pallidum

Prevention strategies of transfusion‐transmitted parasitic infections (TTPIs) in Iran, an endemic area for malaria, toxoplasmosis and leishmaniasis

Prevalence of Toxoplasma gondii Infection in Healthy Volunteer Blood Donors Using Serological and Molecular Methods from Chaharmahal and Bakhtiari Province, Southwest Iran

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